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MED1 MED1 SKI SKI EPHA2 EPHA2 HIPK1 HIPK1 GJA8 GJA8 PYGO2 PYGO2 VIM VIM PITX3 PITX3 CRYAB CRYAB WNT5B WNT5B MIP MIP BMP4 BMP4 HSF4 HSF4 CTNS CTNS CRYBA1 CRYBA1 UNC45B UNC45B TGFB1 TGFB1 LIM2 LIM2 SIX3 SIX3 CRYGD CRYGD CRYGC CRYGC CRYGB CRYGB CRYGA CRYGA CRYBB3 CRYBB3 CRYBB2 CRYBB2 CRYBB1 CRYBB1 ATF4 ATF4 PLAAT1 PLAAT1 HIPK2 HIPK2 CRYGN CRYGN TMOD1 TMOD1 CRYBA4 CRYBA4 CTNNB1 CTNNB1 TDRD7 TDRD7 SIX5 SIX5 PROX1 PROX1 FOXE3 FOXE3 TBC1D20 TBC1D20 WNT2B WNT2B CRYGS CRYGS SLITRK6 SLITRK6 CRYBG3 CRYBG3 SOX1 SOX1 WNT7B WNT7B GATA3 GATA3 FZR1 FZR1 CRYAA CRYAA PAX6 PAX6 MEIS1 MEIS1 FAT1 FAT1 DLG1 DLG1 SLC7A11 SLC7A11 CDON CDON LOC100611078 LOC100611078 SKIL SKIL BFSP1 BFSP1 LENEP LENEP LOC100610468 LOC100610468 NF2 NF2 TGFBR1 TGFBR1 NHS NHS ABI2 ABI2 NECTIN3 NECTIN3 MAF MAF ENSPTRP00000075287 ENSPTRP00000075287 TGFBR2 TGFBR2 KDM5B KDM5B GJE1 GJE1 NECTIN1 NECTIN1 BMP4-2 BMP4-2 CITED2 CITED2 PLAAT3 PLAAT3 ENSPTRP00000082515 ENSPTRP00000082515 BIRC7 BIRC7 BCAR3 BCAR3 WNT5A WNT5A ENSPTRP00000086525 ENSPTRP00000086525 ENSPTRP00000087425 ENSPTRP00000087425 CRYBA2 CRYBA2 FRS2 FRS2 SMAD3 SMAD3 SOX11 SOX11 TBC1D32 TBC1D32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
EPHA2EPH receptor A2. (976 aa)
HIPK1HIPK1 isoform 10. (1210 aa)
GJA8Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (433 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
PITX3Homeobox protein. (302 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MIPMajor intrinsic protein of lens fiber; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HSF4Heat shock transcription factor 4. (498 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
UNC45BUnc-45 myosin chaperone B. (929 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (215 aa)
SIX3SIX homeobox 3. (331 aa)
CRYGDCrystallin gamma D; Belongs to the beta/gamma-crystallin family. (174 aa)
CRYGCCrystallin gamma C; Belongs to the beta/gamma-crystallin family. (174 aa)
CRYGBCrystallin gamma B; Belongs to the beta/gamma-crystallin family. (175 aa)
CRYGACrystallin gamma A; Belongs to the beta/gamma-crystallin family. (174 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
CRYBB2CRYBB2 isoform 1; Belongs to the beta/gamma-crystallin family. (103 aa)
CRYBB1Crystallin beta B1; Belongs to the beta/gamma-crystallin family. (252 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
PLAAT1Phospholipase A and acyltransferase 1. (273 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
TMOD1TMOD1 isoform 1. (359 aa)
CRYBA4Crystallin beta A4; Belongs to the beta/gamma-crystallin family. (196 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TDRD7Tudor domain containing 7. (1098 aa)
SIX5SIX homeobox 5. (738 aa)
PROX1Prospero homeobox 1. (737 aa)
FOXE3FOXE3 isoform 1. (319 aa)
TBC1D20TBC1 domain family, member 20. (403 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CRYGSCrystallin, gamma S; Belongs to the beta/gamma-crystallin family. (178 aa)
SLITRK6SLITRK6 isoform 1. (841 aa)
CRYBG3Crystallin beta-gamma domain containing 3; Belongs to the beta/gamma-crystallin family. (2971 aa)
SOX1SOX1 isoform 1. (391 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
GATA3GATA binding protein 3. (444 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
CRYAACRYAA isoform 1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
PAX6PAX6 isoform 13. (436 aa)
MEIS1MEIS1 isoform 7. (465 aa)
FAT1FAT tumor suppressor homolog 1. (4600 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
LOC100611078Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
SKILSKI like proto-oncogene. (684 aa)
BFSP1Beaded filament structural protein 1; Belongs to the intermediate filament family. (665 aa)
LENEPLens epithelial protein. (61 aa)
LOC100610468Gamma-crystallin F-like. (161 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NHSNHS actin remodeling regulator. (1630 aa)
ABI2Abl interactor 2. (513 aa)
NECTIN3Poliovirus receptor-related 3. (549 aa)
MAFMAF isoform 2; Belongs to the bZIP family. (402 aa)
ENSPTRP00000075287annotation not available (182 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
KDM5BKDM5B isoform 2. (1580 aa)
GJE1Gap junction protein epsilon 1. (205 aa)
NECTIN1NECTIN1 isoform 1. (517 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
PLAAT3Uncharacterized protein. (170 aa)
ENSPTRP00000082515annotation not available (336 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
BCAR3Breast cancer anti-estrogen resistance 3. (825 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000086525annotation not available (336 aa)
ENSPTRP00000087425annotation not available (336 aa)
CRYBA2Crystallin, beta A2; Belongs to the beta/gamma-crystallin family. (197 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
SOX11Transcription factor SOX. (441 aa)
TBC1D32TBC1D32 isoform 4. (1298 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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