STRINGSTRING
LILRB4 LILRB4 MTOR MTOR C1QC C1QC POU4F1 POU4F1 CD101 CD101 HAX1 HAX1 APCS APCS IL20 IL20 GPR137B GPR137B PRXL2A PRXL2A FSHB FSHB TRAF6 TRAF6 GPR137 GPR137 ESRRA ESRRA FADD FADD IAPP IAPP IL23A IL23A IFNG IFNG KITLG KITLG TESC TESC TNFSF11 TNFSF11 RB1 RB1 CUL4A CUL4A ACIN1 ACIN1 FES FES IL34 IL34 ZFPM1 ZFPM1 NF1 NF1 PRKCA PRKCA FSTL3 FSTL3 TGFB1 TGFB1 CEACAM1 CEACAM1 LILRB1 LILRB1 ID2 ID2 TMEM178A TMEM178A FSHR FSHR CASP8 CASP8 INHA INHA INPP5D INPP5D RASSF2 RASSF2 OCSTAMP OCSTAMP LIF LIF PLA2G3 PLA2G3 LTF LTF HCLS1 HCLS1 RBP1 RBP1 ADIPOQ ADIPOQ PF4 PF4 POU4F2 POU4F2 FBXW7 FBXW7 TLR3 TLR3 CAMK4 CAMK4 ENSPTRP00000029460 ENSPTRP00000029460 NDFIP1 NDFIP1 IL12B IL12B RIPK1 RIPK1 TREM2 TREM2 IL17A IL17A CDK6 CDK6 LRRC17 LRRC17 TMEM64 TMEM64 DCSTAMP DCSTAMP TNFRSF11B TNFRSF11B TRIB1 TRIB1 ROR2 ROR2 NINJ1 NINJ1 TFE3 TFE3 ZBTB46 ZBTB46 CTNNB1 CTNNB1 ZNF675 ZNF675 LYN LYN CD74 CD74 CARTPT CARTPT TNFAIP6 TNFAIP6 MAFB MAFB RARA RARA SFRP1 SFRP1 GATA2 GATA2 CD4 CD4 KLF10 KLF10 CCL3 CCL3 EVI2B EVI2B ZFP36L1 ZFP36L1 ENSPTRP00000062048 ENSPTRP00000062048 LILRB3 LILRB3 LOC104003639 LOC104003639 FBXW9 FBXW9 CALCA CALCA ENSPTRP00000065244 ENSPTRP00000065244 PIAS3 PIAS3 ENSPTRP00000065779 ENSPTRP00000065779 PPP3CA PPP3CA FBN1 FBN1 ENSPTRP00000068326 ENSPTRP00000068326 UBASH3B UBASH3B TNF TNF CSF1 CSF1 IL23R IL23R PTPN2 PTPN2 CREB1 CREB1 IRF7 IRF7 LILRB3-2 LILRB3-2 FOXP1 FOXP1 MYC MYC SLC9B2 SLC9B2 NOTCH2 NOTCH2 PIK3R1 PIK3R1 ENSPTRP00000077036 ENSPTRP00000077036 CCR1 CCR1 PPARGC1B PPARGC1B PRDM16 PRDM16 FOS FOS CTNNBIP1 CTNNBIP1 CUL4A-2 CUL4A-2 LOC745935 LOC745935 LOC100612565 LOC100612565 LEF1 LEF1 IL5 IL5 ENSPTRP00000084126 ENSPTRP00000084126 ENSPTRP00000085116 ENSPTRP00000085116 MITF MITF CEBPB CEBPB GPR68 GPR68 HSF1 HSF1 RUNX1 RUNX1 NEDD9 NEDD9 INHBA INHBA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LILRB4LILRB4 isoform 7. (449 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
C1QCComplement C1q C chain. (245 aa)
POU4F1POU domain protein. (350 aa)
CD101CD101 isoform 1. (1021 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
APCSPentaxin. (223 aa)
IL20IL20 isoform 1. (176 aa)
GPR137BG protein-coupled receptor 137B. (399 aa)
PRXL2AChromosome 10 open reading frame 58. (229 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
GPR137G protein-coupled receptor 137. (475 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
IAPPIslet amyloid polypeptide. (89 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
TESCTESC isoform 2. (214 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
RB1RB transcriptional corepressor 1. (928 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
ACIN1ACIN1 isoform 7. (1342 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
IL34IL34 isoform 1. (242 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
NF1Neurofibromin 1. (2839 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
FSTL3Follistatin-like 3 (Secreted glycoprotein). (263 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
LILRB1LILRB1 isoform 3. (697 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
RASSF2Ras association (RalGDS/AF-6) domain family member 2. (326 aa)
OCSTAMPOCSTAMP isoform 1. (565 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
PLA2G3PLA2G3 isoform 1. (509 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (197 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PF4C-X-C motif chemokine. (101 aa)
POU4F2POU domain protein. (406 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL17AIL17A isoform 1. (155 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
LRRC17Leucine rich repeat containing 17. (441 aa)
TMEM64Transmembrane protein 64. (380 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (428 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
NINJ1NINJ1 isoform 1. (152 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (406 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
ZNF675ZNF675 isoform 4. (568 aa)
LYNTyrosine-protein kinase. (512 aa)
CD74CD74 isoform 5. (296 aa)
CARTPTCART prepropeptide. (116 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (277 aa)
MAFBV-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
RARARARA isoform 4. (624 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
GATA2GATA binding protein 2. (480 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
KLF10Kruppel-like factor 10. (480 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
EVI2BEcotropic viral integration site 2B. (448 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ENSPTRP00000062048annotation not available (257 aa)
LILRB3Leukocyte immunoglobulin like receptor B3. (621 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ENSPTRP00000065244annotation not available (463 aa)
PIAS3Protein inhibitor of activated STAT, 3. (628 aa)
ENSPTRP00000065779annotation not available (204 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
FBN1FBN1 isoform 1. (2871 aa)
ENSPTRP00000068326annotation not available (488 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
IL23RIL23R isoform 1. (629 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (421 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
IRF7Interferon regulatory factor 7. (516 aa)
LILRB3-2LILRB3 isoform 3. (643 aa)
FOXP1FOXP1 isoform 2. (693 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SLC9B2Solute carrier family 9B (sodium/hydrogen exchanger), member 1/2. (537 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077036annotation not available (396 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PPARGC1BPPARGC1B isoform 2. (1023 aa)
PRDM16PRDM16 isoform 4. (1276 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
CUL4A-2Cullin 4A. (763 aa)
LOC745935C-C motif chemokine. (87 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
ENSPTRP00000084126annotation not available (117 aa)
ENSPTRP00000085116annotation not available (227 aa)
MITFMITF isoform 1. (519 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
GPR68GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
HSF1Heat shock transcription factor 1. (529 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
INHBAInhibin subunit beta A. (426 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.