STRINGSTRING
TRIB1 TRIB1 POU4F1 POU4F1 CD101 CD101 HAX1 HAX1 IL20 IL20 TRAF6 TRAF6 FADD FADD IL23A IL23A IFNG IFNG KITLG KITLG TESC TESC TNFSF11 TNFSF11 RB1 RB1 ACIN1 ACIN1 FES FES IL34 IL34 PRKCA PRKCA TGFB1 TGFB1 ID2 ID2 CASP8 CASP8 OCSTAMP OCSTAMP LIF LIF PLA2G3 PLA2G3 HCLS1 HCLS1 PF4 PF4 POU4F2 POU4F2 ENSPTRP00000029460 ENSPTRP00000029460 IL12B IL12B RIPK1 RIPK1 TREM2 TREM2 IL17A IL17A NEDD9 NEDD9 RUNX1 RUNX1 HSF1 HSF1 GPR68 GPR68 ENSPTRP00000085116 ENSPTRP00000085116 ENSPTRP00000084126 ENSPTRP00000084126 IL5 IL5 LEF1 LEF1 CTNNBIP1 CTNNBIP1 FOS FOS PPARGC1B PPARGC1B CCR1 CCR1 NOTCH2 NOTCH2 SLC9B2 SLC9B2 CREB1 CREB1 IL23R IL23R CSF1 CSF1 TNF TNF PPP3CA PPP3CA ENSPTRP00000065244 ENSPTRP00000065244 CALCA CALCA LOC104003639 LOC104003639 ENSPTRP00000062048 ENSPTRP00000062048 ZFP36L1 ZFP36L1 EVI2B EVI2B KLF10 KLF10 CD4 CD4 CD74 CD74 NINJ1 NINJ1 ROR2 ROR2 DCSTAMP DCSTAMP TMEM64 TMEM64
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIB1Tribbles pseudokinase 1. (372 aa)
POU4F1POU domain protein. (350 aa)
CD101CD101 isoform 1. (1021 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
IL20IL20 isoform 1. (176 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
TESCTESC isoform 2. (214 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
RB1RB transcriptional corepressor 1. (928 aa)
ACIN1ACIN1 isoform 7. (1342 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
IL34IL34 isoform 1. (242 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
OCSTAMPOCSTAMP isoform 1. (565 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
PLA2G3PLA2G3 isoform 1. (509 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
PF4C-X-C motif chemokine. (101 aa)
POU4F2POU domain protein. (406 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL17AIL17A isoform 1. (155 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
HSF1Heat shock transcription factor 1. (529 aa)
GPR68GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSPTRP00000085116annotation not available (227 aa)
ENSPTRP00000084126annotation not available (117 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPARGC1BPPARGC1B isoform 2. (1023 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
SLC9B2Solute carrier family 9B (sodium/hydrogen exchanger), member 1/2. (537 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
IL23RIL23R isoform 1. (629 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSPTRP00000065244annotation not available (463 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
ENSPTRP00000062048annotation not available (257 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
EVI2BEcotropic viral integration site 2B. (448 aa)
KLF10Kruppel-like factor 10. (480 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
CD74CD74 isoform 5. (296 aa)
NINJ1NINJ1 isoform 1. (152 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
TMEM64Transmembrane protein 64. (380 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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