25 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKRN2	Makorin ring finger protein 2. (418 aa)
	YES1	Tyrosine-protein kinase. (558 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	FGR	Tyrosine-protein kinase. (529 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	SELENOS	SELENOS isoform 5. (218 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	NPY5R	Neuropeptide Y receptor type 5. (445 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	HCK	Tyrosine-protein kinase. (526 aa)
	GPR17	GPR17 isoform 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	RHBDF2	RHBDF2 isoform 4. (789 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
	FURIN	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	ENSPTRP00000081537	annotation not available (449 aa)
	ENSPTRP00000088414	annotation not available (529 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000081537	ENSPTRP00000088414	ENSPTRP00000081537	ENSPTRP00000088414	annotation not available	annotation not available	0.554
ENSPTRP00000081537	FGR	ENSPTRP00000081537	ENSPTRP00000000718	annotation not available	Tyrosine-protein kinase.	0.554
ENSPTRP00000081537	FYN	ENSPTRP00000081537	ENSPTRP00000077482	annotation not available	Tyrosine-protein kinase.	0.942
ENSPTRP00000081537	HCK	ENSPTRP00000081537	ENSPTRP00000022925	annotation not available	Tyrosine-protein kinase.	0.441
ENSPTRP00000081537	LYN	ENSPTRP00000081537	ENSPTRP00000046608	annotation not available	Tyrosine-protein kinase.	0.593
ENSPTRP00000081537	PLCG1	ENSPTRP00000081537	ENSPTRP00000023178	annotation not available	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.483
ENSPTRP00000081537	SRC	ENSPTRP00000081537	ENSPTRP00000076797	annotation not available	Tyrosine-protein kinase.	0.910
ENSPTRP00000081537	SYK	ENSPTRP00000081537	ENSPTRP00000074883	annotation not available	Tyrosine-protein kinase.	0.612
ENSPTRP00000088414	ENSPTRP00000081537	ENSPTRP00000088414	ENSPTRP00000081537	annotation not available	annotation not available	0.554
ENSPTRP00000088414	HCK	ENSPTRP00000088414	ENSPTRP00000022925	annotation not available	Tyrosine-protein kinase.	0.669
ENSPTRP00000088414	LYN	ENSPTRP00000088414	ENSPTRP00000046608	annotation not available	Tyrosine-protein kinase.	0.723
ENSPTRP00000088414	PLCG1	ENSPTRP00000088414	ENSPTRP00000023178	annotation not available	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.422
ENSPTRP00000088414	SRC	ENSPTRP00000088414	ENSPTRP00000076797	annotation not available	Tyrosine-protein kinase.	0.504
ENSPTRP00000088414	SYK	ENSPTRP00000088414	ENSPTRP00000074883	annotation not available	Tyrosine-protein kinase.	0.656
ENSPTRP00000088414	YES1	ENSPTRP00000088414	ENSPTRP00000090543	annotation not available	Tyrosine-protein kinase.	0.556
FGR	ENSPTRP00000081537	ENSPTRP00000000718	ENSPTRP00000081537	Tyrosine-protein kinase.	annotation not available	0.554
FGR	HCK	ENSPTRP00000000718	ENSPTRP00000022925	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.669
FGR	LYN	ENSPTRP00000000718	ENSPTRP00000046608	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.723
FGR	PLCG1	ENSPTRP00000000718	ENSPTRP00000023178	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.422
FGR	SRC	ENSPTRP00000000718	ENSPTRP00000076797	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.504