STRINGSTRING
EDNRB EDNRB AKAP11 AKAP11 AQP6 AQP6 MCAM MCAM ADM ADM HBB HBB AGT AGT CD34 CD34 NPHS2 NPHS2 CHRNB2 CHRNB2 NPR1 NPR1 CLCNKB CLCNKB NPPB NPPB SLC5A2 SLC5A2 SULF1 SULF1 ENSPTRP00000073361 ENSPTRP00000073361 ENSPTRP00000075827 ENSPTRP00000075827 ADGRF5 ADGRF5 UMOD UMOD TFAP2B TFAP2B PON3 PON3 PTPRO PTPRO PKN1 PKN1 CHRNA3 CHRNA3 AKR1C3 AKR1C3 ATP6V0A4-2 ATP6V0A4-2 WFS1 WFS1 ENSPTRP00000080129 ENSPTRP00000080129 BMP4-2 BMP4-2 RRM2B RRM2B SULF2 SULF2 CK820_G0057017 CK820_G0057017 LOC743215 LOC743215 ADRA1A ADRA1A HNF1A HNF1A JCHAIN JCHAIN SGK1 SGK1 ENSPTRP00000086039 ENSPTRP00000086039 TRPV5 TRPV5 GJA5 GJA5 KCNQ1 KCNQ1 ENSPTRP00000087978 ENSPTRP00000087978 CLCNKA CLCNKA MLLT6 MLLT6 BCL2 BCL2 EMP2 EMP2 SERPINF2 SERPINF2 CYBA CYBA ENSPTRP00000092082 ENSPTRP00000092082 ADCY6 ADCY6 AGTR2 AGTR2 AQP2 AQP2 CYP4F2 CYP4F2 ENSPTRP00000070319 ENSPTRP00000070319 DRD2 DRD2 NPR3 NPR3 PPP3CA PPP3CA ENSPTRP00000067500 ENSPTRP00000067500 AGTR1 AGTR1 ENSPTRP00000063164 ENSPTRP00000063164 ENSPTRP00000063084 ENSPTRP00000063084 LOC737549 LOC737549 CLDN4 CLDN4 KCNMA1 KCNMA1 PRKRIP1 PRKRIP1 HAS2 HAS2 SLC22A6 SLC22A6 AVPR2 AVPR2 REN REN SUCNR1 SUCNR1 CYP4F12 CYP4F12 SLC22A12 SLC22A12 HYAL2 HYAL2 KIRREL1 KIRREL1 PRKACB PRKACB CLCN5 CLCN5 SLC4A5 SLC4A5 BCR BCR INPP5K INPP5K TBC1D8B TBC1D8B MAGED2 MAGED2 GSN GSN PCSK5 PCSK5 PRKACG PRKACG AQP3 AQP3 CHRNA6 CHRNA6 TRPV5-2 TRPV5-2 ATP6V0A4 ATP6V0A4 AKR1B1 AKR1B1 PON2 PON2 AQP1 AQP1 EDN1 EDN1 KLHL3 KLHL3 F2RL1 F2RL1 F2R F2R EDNRA EDNRA ABCG2 ABCG2 SLC15A2 SLC15A2 GNAI2 GNAI2 RHOA RHOA XPNPEP3 XPNPEP3 PDGFB PDGFB SLC5A1 SLC5A1 ADORA2A ADORA2A OXT OXT TACR1 TACR1 ATP6V1B1 ATP6V1B1 RHPN2 RHPN2 PRKACA PRKACA MYO5B MYO5B AQP4 AQP4 SLC9A3R1 SLC9A3R1 ITGA3 ITGA3 SLC4A1 SLC4A1 WNK4 WNK4 TRPV1 TRPV1 HSD11B2 HSD11B2 CLDN4-2 CLDN4-2 CHRNB4 CHRNB4 CORO2B CORO2B MYO1E MYO1E AMN AMN LGMN LGMN TMEM63C TMEM63C BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
AKAP11A kinase (PRKA) anchor protein 11. (1901 aa)
AQP6AQP6 isoform 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (282 aa)
MCAMMelanoma cell adhesion molecule. (646 aa)
ADMAdrenomedullin. (185 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
CD34CD34 isoform 1. (328 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
CHRNB2CHRNB2 isoform 2. (502 aa)
NPR1Guanylate cyclase. (1061 aa)
CLCNKBChloride channel protein. (699 aa)
NPPBNatriuretic peptide B. (134 aa)
SLC5A2Solute carrier family 5 member 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (675 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
ENSPTRP00000073361annotation not available (388 aa)
ENSPTRP00000075827annotation not available (533 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
UMODUMOD isoform 1. (690 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
PON3PON3 isoform 1. (354 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
PKN1PKN1 isoform 2. (948 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (503 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
ATP6V0A4-2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
WFS1WFS1 isoform 1. (890 aa)
ENSPTRP00000080129annotation not available (416 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (355 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
CK820_G0057017CLN3 isoform 55. (42 aa)
LOC743215AKR1B1 isoform 13. (294 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
HNF1AHNF1 homeobox A. (662 aa)
JCHAINJoining chain of multimeric IgA and IgM. (159 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ENSPTRP00000086039annotation not available (570 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5. (732 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
ENSPTRP00000087978annotation not available (470 aa)
CLCNKAChloride channel protein. (686 aa)
MLLT6MLLT6 isoform 1. (1093 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] (167 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
CYBACytochrome b-245 alpha chain. (210 aa)
ENSPTRP00000092082annotation not available (189 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
AQP2AQP2 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
CYP4F2Cytochrome P450 family 4 subfamily F member 2; Belongs to the cytochrome P450 family. (572 aa)
ENSPTRP00000070319annotation not available (244 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSPTRP00000067500annotation not available (264 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
ENSPTRP00000063164annotation not available (1061 aa)
ENSPTRP00000063084annotation not available (606 aa)
LOC737549Battenin. (418 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
PRKRIP1PRKR interacting protein 1. (184 aa)
HAS2Hyaluronan synthase 2. (554 aa)
SLC22A6Solute carrier family 22 member 6. (550 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
SUCNR1SUCNR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CYP4F12Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family. (524 aa)
SLC22A12Solute carrier family 22 member 12. (553 aa)
HYAL2Hyaluronidase. (473 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (757 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CLCN5Chloride channel protein. (816 aa)
SLC4A5Anion exchange protein. (1136 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
TBC1D8BTBC1 domain family, member 8B (With GRAM domain). (1120 aa)
MAGED2Melanoma antigen family D, 2. (606 aa)
GSNGSN isoform 3. (782 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
CHRNA6Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (494 aa)
TRPV5-2Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
ATP6V0A4ATPase H+ transporting V0 subunit a4. (840 aa)
AKR1B1Aldo-keto reductase family 1, member B1 (Aldose reductase). (316 aa)
PON2PON2 isoform 4. (375 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
EDN1EDN1 isoform 1. (212 aa)
KLHL3Kelch like family member 3. (608 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
F2RCoagulation factor II (Thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ABCG2ATP-binding cassette, sub-family G (WHITE), member 2. (655 aa)
SLC15A2Solute carrier family 15 member 2. (729 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
RHOARas homolog family member A. (193 aa)
XPNPEP3X-prolyl aminopeptidase (Aminopeptidase P) 3, putative. (507 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SLC5A1Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (664 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
RHPN2RHPN2 isoform 2. (686 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
MYO5BT0040421 isoform 1. (1849 aa)
AQP4AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
SLC4A1Anion exchange protein. (921 aa)
WNK4WNK lysine deficient protein kinase 4. (1282 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (405 aa)
CLDN4-2Claudin 4. (209 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (498 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
AMNAMN isoform 2. (453 aa)
LGMNLGMN isoform 1. (433 aa)
TMEM63CCalcium permeable stress-gated cation channel 1 isoform X1. (806 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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