26 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	GATA6	GATA binding protein 6. (594 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LRP2	LRP2 isoform 1. (4655 aa)
	ROBO2	Roundabout guidance receptor 2. (1439 aa)
	PARVA	PARVA isoform 1. (412 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	ZFPM2	ZFPM2 isoform 3. (1151 aa)
	ROBO1	Roundabout guidance receptor 1. (1684 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
	ENG	ENG isoform 1. (658 aa)
	SEMA3C	SEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	NKX2-5	NKX2-5 isoform 1. (325 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TBX1	TBX1 isoform 1. (478 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSPTRP00000010780	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	BMPR2	ENSPTRP00000010780	ENSPTRP00000048858	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.877
BMP4	ENSPTRP00000064416	ENSPTRP00000010780	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	FGFR2	ENSPTRP00000010780	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4	GATA6	ENSPTRP00000010780	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4	ISL1	ENSPTRP00000010780	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4	NKX2-5	ENSPTRP00000010780	ENSPTRP00000029961	Bone morphogenetic protein 4.	NKX2-5 isoform 1.	0.507
BMP4	SMAD4	ENSPTRP00000010780	ENSPTRP00000017047	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.853
BMP4	SMAD6	ENSPTRP00000010780	ENSPTRP00000012318	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.636
BMP4	TBX2	ENSPTRP00000010780	ENSPTRP00000016104	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.427
BMP4	TGFBR2	ENSPTRP00000010780	ENSPTRP00000075305	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.482
BMP4-2	BMPR1A	ENSPTRP00000080656	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.892
BMP4-2	BMPR2	ENSPTRP00000080656	ENSPTRP00000048858	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.877
BMP4-2	ENSPTRP00000064416	ENSPTRP00000080656	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	FGFR2	ENSPTRP00000080656	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4-2	GATA6	ENSPTRP00000080656	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4-2	ISL1	ENSPTRP00000080656	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4-2	NKX2-5	ENSPTRP00000080656	ENSPTRP00000029961	Bone morphogenetic protein 4.	NKX2-5 isoform 1.	0.507