STRINGSTRING
DLL4 DLL4 SNAI1 SNAI1 TNFRSF1A TNFRSF1A NFATC1 NFATC1 ZBTB14 ZBTB14 GATA3 GATA3 ENSPTRP00000064416 ENSPTRP00000064416 ROCK2 ROCK2 HECTD1 HECTD1 MDM4 MDM4 SOX4 SOX4 BMPR2 BMPR2 TWIST1 TWIST1 PDE2A PDE2A OLFM1 OLFM1 NOTCH1 NOTCH1 SNAI2 SNAI2 SOX9 SOX9 NOS3 NOS3 TBX20 TBX20 HEY2 HEY2 PRDM1 PRDM1 NKX2-5 NKX2-5 SLIT3 SLIT3 MATR3 MATR3 ADAMTS9 ADAMTS9 JAG1 JAG1 BMP2 BMP2 EMILIN1 EMILIN1 TGFB1 TGFB1 GATA5 GATA5 TGFBR2 TGFBR2 ACVR1 ACVR1 NOTCH2 NOTCH2 GATA4 GATA4 ZFPM1 ZFPM1 SMAD6 SMAD6 BMP4 BMP4 RB1 RB1 APLNR APLNR BMPR1A BMPR1A TGFB2 TGFB2 EFNA1 EFNA1 CCN1 CCN1 TIE1 TIE1 TNFRSF1B TNFRSF1B NPPA NPPA STRA6 STRA6 RBPJ RBPJ SLIT2 SLIT2 BMP4-2 BMP4-2 ELN ELN SMAD4 SMAD4 GJA5 GJA5 FGFRL1 FGFRL1 DCHS1 DCHS1 HEYL HEYL MEF2C MEF2C ROBO2 ROBO2 MTOR MTOR SHOX2 SHOX2 ROBO1 ROBO1 SCX SCX HEY1 HEY1 TBX5 TBX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. (853 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
GATA3GATA binding protein 3. (444 aa)
ENSPTRP00000064416annotation not available (502 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
SOX4Transcription factor SOX. (474 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
TWIST1TWIST1 isoform 2. (163 aa)
PDE2APhosphodiesterase. (941 aa)
OLFM1OLFM1 isoform 3. (485 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PRDM1PR/SET domain 1. (825 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
MATR3MATR3 isoform 14. (895 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GATA5GATA binding protein 5. (397 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GATA4GATA binding protein 4. (443 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RB1RB transcriptional corepressor 1. (928 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TNFRSF1BTumor necrosis factor receptor superfamily, member 1B. (461 aa)
NPPANatriuretic peptide A. (153 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ELNELN isoform 3. (790 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SHOX2SHOX2 isoform 2. (343 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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