STRINGSTRING
NOTCH1 NOTCH1 TNFRSF1B TNFRSF1B TIE1 TIE1 EFNA1 EFNA1 RB1 RB1 BMP4 BMP4 SMAD6 SMAD6 SOX9 SOX9 TGFB1 TGFB1 EMILIN1 EMILIN1 BMP2 BMP2 JAG1 JAG1 SLIT3 SLIT3 NKX2-5 NKX2-5 HEY2 HEY2 TBX20 TBX20 NOS3 NOS3 SNAI2 SNAI2 NPPA NPPA TWIST1 TWIST1 BMPR2 BMPR2 ROCK2 ROCK2 GATA3 GATA3 NFATC1 NFATC1 TNFRSF1A TNFRSF1A SNAI1 SNAI1 HEY1 HEY1 DLL4 DLL4 ROBO1 ROBO1 GATA5 GATA5 GATA4 GATA4 RBPJ RBPJ SLIT2 SLIT2 BMP4-2 BMP4-2 ELN ELN HEYL HEYL ROBO2 ROBO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH1NOTCH1 isoform 1. (2555 aa)
TNFRSF1BTumor necrosis factor receptor superfamily, member 1B. (461 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
RB1RB transcriptional corepressor 1. (928 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
TBX20T-box transcription factor 20. (447 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NPPANatriuretic peptide A. (153 aa)
TWIST1TWIST1 isoform 2. (163 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
GATA3GATA binding protein 3. (444 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. (853 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
GATA5GATA binding protein 5. (397 aa)
GATA4GATA binding protein 4. (443 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ELNELN isoform 3. (790 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.