STRINGSTRING
CITED2 CITED2 TBX2 TBX2 SOX9 SOX9 SMAD4 SMAD4 BMP2 BMP2 JAG1 JAG1 BMP7 BMP7 RBM24 RBM24 ISL1 ISL1 BMP5 BMP5 HEY2 HEY2 TBX20 TBX20 NOS3 NOS3 SNAI2 SNAI2 ENG ENG NOTCH1 NOTCH1 TWIST1 TWIST1 BMPR2 BMPR2 MDM4 MDM4 MSX1 MSX1 ENSPTRP00000064416 ENSPTRP00000064416 SNAI1 SNAI1 TBX5 TBX5 HEY1 HEY1 ROBO1 ROBO1 GATA5 GATA5 TGFBR2 TGFBR2 FGF8 FGF8 ACVR1 ACVR1 GATA4 GATA4 RBPJ RBPJ BMP4-2 BMP4-2 CRELD1 CRELD1 TBX3 TBX3 TMEM100 TMEM100 DCHS1 DCHS1 HEYL HEYL ROBO2 ROBO2 BMP4 BMP4 ERBB3 ERBB3 ACVRL1 ACVRL1 APLNR APLNR BMPR1A BMPR1A TGFB2 TGFB2 CPLANE2 CPLANE2 FOXF1 FOXF1 NOG NOG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TBX2T-box transcription factor 2. (712 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
RBM24RNA binding motif protein 24. (254 aa)
ISL1ISL LIM homeobox 1. (349 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
TBX20T-box transcription factor 20. (447 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
TWIST1TWIST1 isoform 2. (163 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
ENSPTRP00000064416annotation not available (502 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TBX5T-box transcription factor 5. (518 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
GATA5GATA binding protein 5. (397 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GATA4GATA binding protein 4. (443 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CRELD1Cysteine-rich with EGF-like domains 1. (420 aa)
TBX3T-box transcription factor 3. (743 aa)
TMEM100Transmembrane protein 100. (134 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
FOXF1FOXF1 isoform 1. (433 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.