STRINGSTRING
NSD2 NSD2 FZD1-2 FZD1-2 ENSPTRP00000092784 ENSPTRP00000092784 OVOL2 OVOL2 NRG1 NRG1 ADPRHL1 ADPRHL1 SHOX2 SHOX2 ROBO2 ROBO2 SOX11 SOX11 MEF2C MEF2C PARVA PARVA HEYL HEYL MYH6 MYH6 COL11A1 COL11A1 FGFRL1 FGFRL1 FZD1 FZD1 FHL2 FHL2 WNT5A WNT5A TBX3 TBX3 MYH7 MYH7 CITED2 CITED2 BMP4-2 BMP4-2 SLIT2 SLIT2 MYL2 MYL2 RBPJ RBPJ BMP10 BMP10 SMARCD3-2 SMARCD3-2 MYL10-2 MYL10-2 GATA4 GATA4 NOTCH2 NOTCH2 ACVR1 ACVR1 FGF8 FGF8 TGFBR2 TGFBR2 ZFPM2 ZFPM2 DNAH11 DNAH11 ROBO1 ROBO1 TGFBR1 TGFBR1 TNNT2 TNNT2 DLL4 DLL4 TEK TEK HEY1 HEY1 TBX5 TBX5 SMO-2 SMO-2 TGFBR3 TGFBR3 FOXC1 FOXC1 GATA3 GATA3 RYR2 RYR2 ENSPTRP00000064416 ENSPTRP00000064416 HES1 HES1 EGLN1 EGLN1 FOXC2 FOXC2 FOXH1-2 FOXH1-2 SOS1 SOS1 PROX1 PROX1 HAND2 HAND2 SOX4 SOX4 BMPR2 BMPR2 TNNI3 TNNI3 ADGRG6 ADGRG6 TPM1 TPM1 CPE CPE NOTCH1 NOTCH1 ENG ENG FOXH1 FOXH1 GRHL2 GRHL2 CHD7 CHD7 SMARCD3 SMARCD3 NOS3 NOS3 SMO SMO WNT2 WNT2 MYL10 MYL10 SEMA3C SEMA3C TBX20 TBX20 HEY2 HEY2 BMP5 BMP5 SRF SRF DSP DSP NKX2-5 NKX2-5 SLIT3 SLIT3 HAND1 HAND1 PTCD2 PTCD2 ISL1 ISL1 NPY5R NPY5R NPY2R NPY2R SFRP2 SFRP2 EDNRA EDNRA HEG1 HEG1 TNNC1 TNNC1 MYL3 MYL3 CAV3 CAV3 TBX1 TBX1 ADAMTS1 ADAMTS1 BMP7 BMP7 JAG1 JAG1 BMP2 BMP2 NRP2 NRP2 LRP2 LRP2 PPP1R13L PPP1R13L GSK3A GSK3A TGFB1 TGFB1 SMAD4 SMAD4 SMAD7 SMAD7 GATA6 GATA6 TBX2 TBX2 MKS1 MKS1 NOG NOG FZD2 FZD2 MED1 MED1 TP53 TP53 ZFPM1 ZFPM1 FOXF1 FOXF1 MESP1 MESP1 SMAD6 SMAD6 HIF1A HIF1A BMP4 BMP4 SAV1 SAV1 PKP2 PKP2 WNT11 WNT11 APLNR APLNR MYBPC3 MYBPC3 FGFR2 FGFR2 BMPR1A BMPR1A NRP1 NRP1 TGFB2 TGFB2 TNNI1 TNNI1 RBM15 RBM15 CCN1 CCN1 POU4F1 POU4F1 DHRS3 DHRS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
ENSPTRP00000092784annotation not available (75 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
NRG1NRG1 isoform 3. (713 aa)
ADPRHL1ADPRHL1 isoform 2. (1673 aa)
SHOX2SHOX2 isoform 2. (343 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
SOX11Transcription factor SOX. (441 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PARVAPARVA isoform 1. (412 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FHL2FHL2 isoform 4. (389 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TBX3T-box transcription factor 3. (743 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
MYL10-2MYL10 isoform 1. (226 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
DNAH11Dynein axonemal heavy chain 11. (4518 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
FOXC1FOXC1 isoform 1. (550 aa)
GATA3GATA binding protein 3. (444 aa)
RYR2RYR2 isoform 1. (4941 aa)
ENSPTRP00000064416annotation not available (502 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
EGLN1EGLN1 isoform 1. (426 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
FOXH1-2Forkhead box H1. (365 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PROX1Prospero homeobox 1. (737 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SOX4Transcription factor SOX. (474 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
TNNI3TNNI3 isoform 2. (169 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
CPECarboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. (476 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
FOXH1FOXH1 isoform 1. (365 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
CHD7CHD7 isoform 1. (2997 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MYL10ADCY7 isoform 13. (226 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
DSPDSP isoform 1. (2871 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HEG1HEG1 isoform 1. (1381 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TBX1TBX1 isoform 1. (478 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1. (967 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
LRP2LRP2 isoform 1. (4655 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
GATA6GATA binding protein 6. (594 aa)
TBX2T-box transcription factor 2. (712 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
FOXF1FOXF1 isoform 1. (433 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PKP2PKP2 isoform 1. (837 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
RBM15RNA binding motif protein 15. (977 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
POU4F1POU domain protein. (350 aa)
DHRS3Dehydrogenase/reductase (SDR family) member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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