STRINGSTRING
SOX4 SOX4 POU4F1 POU4F1 TNNI1 TNNI1 TGFB2 TGFB2 BMPR1A BMPR1A FGFR2 FGFR2 MYBPC3 MYBPC3 PKP2 PKP2 HIF1A HIF1A MESP1 MESP1 FOXF1 FOXF1 MED1 MED1 NOG NOG SMAD7 SMAD7 SMAD4 SMAD4 TGFB1 TGFB1 GSK3A GSK3A PPP1R13L PPP1R13L LRP2 LRP2 JAG1 JAG1 MYL3 MYL3 TNNC1 TNNC1 HEG1 HEG1 EDNRA EDNRA SFRP2 SFRP2 NPY2R NPY2R NPY5R NPY5R ISL1 ISL1 PTCD2 PTCD2 HAND1 HAND1 NKX2-5 NKX2-5 DSP DSP HEY2 HEY2 TBX20 TBX20 SEMA3C SEMA3C MYL10 MYL10 SMARCD3 SMARCD3 CHD7 CHD7 GRHL2 GRHL2 FOXH1 FOXH1 ENG ENG NOTCH1 NOTCH1 CPE CPE TPM1 TPM1 TNNI3 TNNI3 HAND2 HAND2 PROX1 PROX1 FOXH1-2 FOXH1-2 FOXC2 FOXC2 ENSPTRP00000064416 ENSPTRP00000064416 RYR2 RYR2 GATA3 GATA3 FOXC1 FOXC1 TGFBR3 TGFBR3 TBX5 TBX5 HEY1 HEY1 DLL4 DLL4 TNNT2 TNNT2 TGFBR1 TGFBR1 ZFPM2 ZFPM2 TGFBR2 TGFBR2 GATA4 GATA4 MYL10-2 MYL10-2 SMARCD3-2 SMARCD3-2 BMP10 BMP10 RBPJ RBPJ MYL2 MYL2 MYH7 MYH7 COL11A1 COL11A1 MYH6 MYH6 HEYL HEYL MEF2C MEF2C SOX11 SOX11 NRG1 NRG1 ENSPTRP00000092784 ENSPTRP00000092784
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX4Transcription factor SOX. (474 aa)
POU4F1POU domain protein. (350 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
PKP2PKP2 isoform 1. (837 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
FOXF1FOXF1 isoform 1. (433 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
LRP2LRP2 isoform 1. (4655 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
HEG1HEG1 isoform 1. (1381 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
DSPDSP isoform 1. (2871 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
TBX20T-box transcription factor 20. (447 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
MYL10ADCY7 isoform 13. (226 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
CHD7CHD7 isoform 1. (2997 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
FOXH1FOXH1 isoform 1. (365 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CPECarboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. (476 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
TNNI3TNNI3 isoform 2. (169 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PROX1Prospero homeobox 1. (737 aa)
FOXH1-2Forkhead box H1. (365 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
ENSPTRP00000064416annotation not available (502 aa)
RYR2RYR2 isoform 1. (4941 aa)
GATA3GATA binding protein 3. (444 aa)
FOXC1FOXC1 isoform 1. (550 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
TBX5T-box transcription factor 5. (518 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
GATA4GATA binding protein 4. (443 aa)
MYL10-2MYL10 isoform 1. (226 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOX11Transcription factor SOX. (441 aa)
NRG1NRG1 isoform 3. (713 aa)
ENSPTRP00000092784annotation not available (75 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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