STRINGSTRING
ZFPM1 ZFPM1 WNT2 WNT2 TBX20 TBX20 HEY2 HEY2 NKX2-5 NKX2-5 ISL1 ISL1 NSD2 NSD2 HEG1 HEG1 BMP2 BMP2 NOG NOG SMO SMO MESP1 MESP1 TGFB2 TGFB2 CCN1 CCN1 SHOX2 SHOX2 MYH6 MYH6 WNT5A WNT5A BMP10 BMP10 GATA4 GATA4 NOTCH2 NOTCH2 ACVR1 ACVR1 DLL4 DLL4 TBX5 TBX5 SMO-2 SMO-2 SOS1 SOS1 PROX1 PROX1 SOX4 SOX4 BMPR2 BMPR2 NOTCH1 NOTCH1 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFPM1ZFPM1 isoform 1. (974 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
HEG1HEG1 isoform 1. (1381 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
SHOX2SHOX2 isoform 2. (343 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
TBX5T-box transcription factor 5. (518 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PROX1Prospero homeobox 1. (737 aa)
SOX4Transcription factor SOX. (474 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.