STRINGSTRING
BMPR1A BMPR1A RBPJ RBPJ NRG1 NRG1 DLL4 DLL4 ENSPTRP00000064416 ENSPTRP00000064416 FOXH1-2 FOXH1-2 TGFB2 TGFB2 NOTCH1 NOTCH1 ENG ENG FOXH1 FOXH1 CHD7 CHD7 HEY2 HEY2 NKX2-5 NKX2-5 HEG1 HEG1 MED1 MED1 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
NRG1NRG1 isoform 3. (713 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ENSPTRP00000064416annotation not available (502 aa)
FOXH1-2Forkhead box H1. (365 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
FOXH1FOXH1 isoform 1. (365 aa)
CHD7CHD7 isoform 1. (2997 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
HEG1HEG1 isoform 1. (1381 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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