23 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Others

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protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (408 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	SHOX2	SHOX2 isoform 2. (343 aa)
	MYH6	MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	ZIC3	Zic family member 3. (466 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
	TREX1	Three prime repair exonuclease 1. (369 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	GJB6	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (228 aa)
	ENG	ENG isoform 1. (658 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	NKX2-5	NKX2-5 isoform 1. (325 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	GATA6	GATA binding protein 6. (594 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	HCN4	Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMP4	ENSPTRP00000078228	ENSPTRP00000010780	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.505
BMP10	BMP4-2	ENSPTRP00000078228	ENSPTRP00000080656	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.505
BMP10	ENG	ENSPTRP00000078228	ENSPTRP00000036576	Bone morphogenetic protein 10.	ENG isoform 1.	0.824
BMP10	HCN4	ENSPTRP00000078228	ENSPTRP00000012412	Bone morphogenetic protein 10.	Hyperpolarization activated cyclic nucleotide gated potassium channel 4.	0.407
BMP10	MYH6	ENSPTRP00000078228	ENSPTRP00000089173	Bone morphogenetic protein 10.	MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.635
BMP10	NKX2-5	ENSPTRP00000078228	ENSPTRP00000029961	Bone morphogenetic protein 10.	NKX2-5 isoform 1.	0.514
BMP10	NOG	ENSPTRP00000078228	ENSPTRP00000016018	Bone morphogenetic protein 10.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.416
BMP4	BMP10	ENSPTRP00000010780	ENSPTRP00000078228	Bone morphogenetic protein 4.	Bone morphogenetic protein 10.	0.505
BMP4	GATA6	ENSPTRP00000010780	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4	ISL1	ENSPTRP00000010780	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4	NKX2-5	ENSPTRP00000010780	ENSPTRP00000029961	Bone morphogenetic protein 4.	NKX2-5 isoform 1.	0.507
BMP4	NOG	ENSPTRP00000010780	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	TBX3	ENSPTRP00000010780	ENSPTRP00000084833	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.403
BMP4-2	BMP10	ENSPTRP00000080656	ENSPTRP00000078228	Bone morphogenetic protein 4.	Bone morphogenetic protein 10.	0.505
BMP4-2	GATA6	ENSPTRP00000080656	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4-2	ISL1	ENSPTRP00000080656	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4-2	NKX2-5	ENSPTRP00000080656	ENSPTRP00000029961	Bone morphogenetic protein 4.	NKX2-5 isoform 1.	0.507
BMP4-2	NOG	ENSPTRP00000080656	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.983
BMP4-2	TBX3	ENSPTRP00000080656	ENSPTRP00000084833	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.403
CACNA1G	HCN4	ENSPTRP00000065836	ENSPTRP00000012412	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Hyperpolarization activated cyclic nucleotide gated potassium channel 4.	0.508