STRINGSTRING
DSP DSP POU4F1 POU4F1 CCN1 CCN1 LMO4 LMO4 RBM15 RBM15 TNNI1 TNNI1 TGFB2 TGFB2 BMPR1A BMPR1A FGFR2 FGFR2 MYBPC3 MYBPC3 APLNR APLNR WNT11 WNT11 PKP2 PKP2 SAV1 SAV1 BMP4 BMP4 HIF1A HIF1A TRIP11 TRIP11 SMAD6 SMAD6 MESP1 MESP1 FOXF1 FOXF1 ZFPM1 ZFPM1 MYOCD MYOCD MED1 MED1 FZD2 FZD2 NOG NOG GREB1 GREB1 SMAD7 SMAD7 SMAD4 SMAD4 DAND5 DAND5 TGFB1 TGFB1 GSK3A GSK3A PPP1R13L PPP1R13L LRP2 LRP2 JAG1 JAG1 MYL3 MYL3 TNNC1 TNNC1 HEG1 HEG1 NSD2 NSD2 EDNRA EDNRA SFRP2 SFRP2 NPY2R NPY2R NPY5R NPY5R CPLANE1 CPLANE1 ISL1 ISL1 PTCD2 PTCD2 MATR3 MATR3 HAND1 HAND1 SLIT3 SLIT3 NKX2-5 NKX2-5 FZD1-2 FZD1-2 ENSPTRP00000092784 ENSPTRP00000092784 NRG1 NRG1 ROBO2 ROBO2 CK820_G0054677 CK820_G0054677 SOX11 SOX11 MEF2C MEF2C FRS2 FRS2 HEYL HEYL MYH6 MYH6 COL11A1 COL11A1 FGFRL1 FGFRL1 FZD1 FZD1 PTK7 PTK7 GJA5 GJA5 WNT5A WNT5A PAX8 PAX8 TBX3 TBX3 ENSPTRP00000084090 ENSPTRP00000084090 MYH7 MYH7 CITED2 CITED2 BMP4-2 BMP4-2 ZMPSTE24 ZMPSTE24 SLIT2 SLIT2 MYL2 MYL2 RBPJ RBPJ STRA6 STRA6 DCTN5 DCTN5 NPRL3 NPRL3 BMP10 BMP10 ENSPTRP00000078044 ENSPTRP00000078044 SMARCD3-2 SMARCD3-2 ENSPTRP00000076988 ENSPTRP00000076988 MYL10-2 MYL10-2 SALL4 SALL4 GATA4 GATA4 ACVR1 ACVR1 TGFBR2 TGFBR2 ZFPM2 ZFPM2 ROBO1 ROBO1 SUFU SUFU TGFBR1 TGFBR1 TNNT2 TNNT2 DLL4 DLL4 ENSPTRP00000069764 ENSPTRP00000069764 SCN5A SCN5A HEY1 HEY1 TBX5 TBX5 GREB1L GREB1L LUZP1 LUZP1 TGFBR3 TGFBR3 LOC736439 LOC736439 FOXC1 FOXC1 GATA3 GATA3 SALL1 SALL1 RYR2 RYR2 CK820_G0046635 CK820_G0046635 ENSPTRP00000064416 ENSPTRP00000064416 HES1 HES1 HOXA13 HOXA13 EGLN1 EGLN1 HECTD1 HECTD1 KCNK2 KCNK2 FOXC2 FOXC2 FOXH1-2 FOXH1-2 MDM4 MDM4 PROX1 PROX1 HAND2 HAND2 SOX4 SOX4 XIRP2 XIRP2 CNTRL CNTRL BMPR2 BMPR2 TNNI3 TNNI3 HOXA13-2 HOXA13-2 PDE2A PDE2A AP2B1 AP2B1 TPM1 TPM1 CPE CPE NOTCH1 NOTCH1 ENG ENG FOXH1 FOXH1 TMEM65 TMEM65 GRHL2 GRHL2 CHD7 CHD7 SMARCD3 SMARCD3 NOS3 NOS3 MYL10 MYL10 SEMA3C SEMA3C TBX20 TBX20 HEY2 HEY2 PRDM1 PRDM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSPDSP isoform 1. (2871 aa)
POU4F1POU domain protein. (350 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
LMO4LIM domain only 4. (165 aa)
RBM15RNA binding motif protein 15. (977 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKP2PKP2 isoform 1. (837 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
FOXF1FOXF1 isoform 1. (433 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
MYOCDMYOCD isoform 2. (986 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
LRP2LRP2 isoform 1. (4655 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
HEG1HEG1 isoform 1. (1381 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
MATR3MATR3 isoform 14. (895 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
ENSPTRP00000092784annotation not available (75 aa)
NRG1NRG1 isoform 3. (713 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
CK820_G0054677NPRL3 isoform 10. (74 aa)
SOX11Transcription factor SOX. (441 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PAX8PAX8 isoform 1. (456 aa)
TBX3T-box transcription factor 3. (743 aa)
ENSPTRP00000084090annotation not available (121 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
DCTN5Dynactin subunit 5. (182 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPTRP00000078044annotation not available (170 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
ENSPTRP00000076988annotation not available (871 aa)
MYL10-2MYL10 isoform 1. (226 aa)
SALL4SALL4 isoform 1. (1053 aa)
GATA4GATA binding protein 4. (443 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ENSPTRP00000069764annotation not available (1213 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
FOXC1FOXC1 isoform 1. (550 aa)
GATA3GATA binding protein 3. (444 aa)
SALL1SALL1 isoform 2. (1326 aa)
RYR2RYR2 isoform 1. (4941 aa)
CK820_G0046635NACA isoform 1. (1839 aa)
ENSPTRP00000064416annotation not available (502 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HOXA13Homeobox A13. (388 aa)
EGLN1EGLN1 isoform 1. (426 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
FOXH1-2Forkhead box H1. (365 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
PROX1Prospero homeobox 1. (737 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SOX4Transcription factor SOX. (474 aa)
XIRP2XIRP2 isoform 3. (3549 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
TNNI3TNNI3 isoform 2. (169 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
PDE2APhosphodiesterase. (941 aa)
AP2B1AP complex subunit beta. (951 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
CPECarboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. (476 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
FOXH1FOXH1 isoform 1. (365 aa)
TMEM65Transmembrane protein 65. (267 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
CHD7CHD7 isoform 1. (2997 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
MYL10ADCY7 isoform 13. (226 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PRDM1PR/SET domain 1. (825 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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