STRINGSTRING
PDE2A PDE2A HOXA13-2 HOXA13-2 ADAMTS6 ADAMTS6 SMAD7 SMAD7 BMPR2 BMPR2 CNTRL CNTRL XIRP2 XIRP2 SOX4 SOX4 PROX1 PROX1 MDM4 MDM4 MAML1 MAML1 HECTD1 HECTD1 EGLN1 EGLN1 HOXA13 HOXA13 SALL4 SALL4 GATA4 GATA4 NOTCH2 NOTCH2 ACVR1 ACVR1 FGF8 FGF8 TGFBR2 TGFBR2 ZFPM2 ZFPM2 DNAH11 DNAH11 ROBO1 ROBO1 SUFU SUFU TGFBR1 TGFBR1 ENSPTRP00000069764 ENSPTRP00000069764 HEY1 HEY1 TBX5 TBX5 SMO-2 SMO-2 LUZP1 LUZP1 TGFBR3 TGFBR3 LOC736439 LOC736439 ZBTB14 ZBTB14 GATA3 GATA3 SALL1 SALL1 ENSPTRP00000064416 ENSPTRP00000064416 HES1 HES1 FZD1-2 FZD1-2 TAB1 TAB1 ROBO2 ROBO2 CK820_G0054677 CK820_G0054677 SOX11 SOX11 FRS2 FRS2 PARVA PARVA HEYL HEYL FGFRL1 FGFRL1 FZD1 FZD1 PTK7 PTK7 GJA5 GJA5 WNT5A WNT5A PAX8 PAX8 TBX3 TBX3 SMAD4 SMAD4 DAND5 DAND5 SNX17 SNX17 LRP2 LRP2 NRP2 NRP2 JAG1 JAG1 BMP7 BMP7 TBX1 TBX1 HEG1 HEG1 PLXND1 PLXND1 NSD2 NSD2 CPLANE1 CPLANE1 ISL1 ISL1 MATR3 MATR3 HAND1 HAND1 SLIT3 SLIT3 NKX2-5 NKX2-5 BMP5 BMP5 PRDM1 PRDM1 HEY2 HEY2 TBX20 TBX20 SEMA3C SEMA3C SMO SMO NOS3 NOS3 DHRS3 DHRS3 CCN1 CCN1 LMO4 LMO4 RBM15 RBM15 TGFB2 TGFB2 NRP1 NRP1 BMPR1A BMPR1A FGFR2 FGFR2 APLNR APLNR WNT11 WNT11 SAV1 SAV1 BMP4 BMP4 TRIP11 TRIP11 SMAD6 SMAD6 ZFPM1 ZFPM1 TP53 TP53 FZD2 FZD2 NOG NOG MKS1 MKS1 TBX2 TBX2 GATA6 GATA6 CRELD1 CRELD1 CITED2 CITED2 BMP4-2 BMP4-2 SLIT2 SLIT2 RBPJ RBPJ STRA6 STRA6 DCTN5 DCTN5 NPRL3 NPRL3 ENSPTRP00000078044 ENSPTRP00000078044 ENSPTRP00000076988 ENSPTRP00000076988 CHD7 CHD7 ENG ENG NOTCH1 NOTCH1 AP2B1 AP2B1 ANK2 ANK2 NDST1 NDST1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE2APhosphodiesterase. (941 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif, 6. (1117 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
XIRP2XIRP2 isoform 3. (3549 aa)
SOX4Transcription factor SOX. (474 aa)
PROX1Prospero homeobox 1. (737 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
MAML1MAML1 isoform 1. (1016 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
EGLN1EGLN1 isoform 1. (426 aa)
HOXA13Homeobox A13. (388 aa)
SALL4SALL4 isoform 1. (1053 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
DNAH11Dynein axonemal heavy chain 11. (4518 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENSPTRP00000069764annotation not available (1213 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
GATA3GATA binding protein 3. (444 aa)
SALL1SALL1 isoform 2. (1326 aa)
ENSPTRP00000064416annotation not available (502 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
CK820_G0054677NPRL3 isoform 10. (74 aa)
SOX11Transcription factor SOX. (441 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
PARVAPARVA isoform 1. (412 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PAX8PAX8 isoform 1. (456 aa)
TBX3T-box transcription factor 3. (743 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
SNX17Sorting nexin 17. (470 aa)
LRP2LRP2 isoform 1. (4655 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TBX1TBX1 isoform 1. (478 aa)
HEG1HEG1 isoform 1. (1381 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
ISL1ISL LIM homeobox 1. (349 aa)
MATR3MATR3 isoform 14. (895 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PRDM1PR/SET domain 1. (825 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
TBX20T-box transcription factor 20. (447 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
DHRS3Dehydrogenase/reductase (SDR family) member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
LMO4LIM domain only 4. (165 aa)
RBM15RNA binding motif protein 15. (977 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
TBX2T-box transcription factor 2. (712 aa)
GATA6GATA binding protein 6. (594 aa)
CRELD1Cysteine-rich with EGF-like domains 1. (420 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
DCTN5Dynactin subunit 5. (182 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
ENSPTRP00000078044annotation not available (170 aa)
ENSPTRP00000076988annotation not available (871 aa)
CHD7CHD7 isoform 1. (2997 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AP2B1AP complex subunit beta. (951 aa)
ANK2ANK2 isoform 1. (3957 aa)
NDST1N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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