STRINGSTRING
CCN1 CCN1 LMO4 LMO4 RBM15 RBM15 TGFB2 TGFB2 BMPR1A BMPR1A SLIT2 SLIT2 BMP4-2 BMP4-2 CITED2 CITED2 TBX3 TBX3 PAX8 PAX8 WNT5A WNT5A GJA5 GJA5 PTK7 PTK7 FZD1 FZD1 FGFRL1 FGFRL1 HEYL HEYL FRS2 FRS2 SOX11 SOX11 FGFR2 FGFR2 CK820_G0054677 CK820_G0054677 ROBO2 ROBO2 FZD1-2 FZD1-2 APLNR APLNR WNT11 WNT11 SAV1 SAV1 BMP4 BMP4 TRIP11 TRIP11 SMAD6 SMAD6 ZFPM1 ZFPM1 FZD2 FZD2 NOG NOG SMAD7 SMAD7 SMAD4 SMAD4 DAND5 DAND5 LRP2 LRP2 HEG1 HEG1 NSD2 NSD2 CPLANE1 CPLANE1 MATR3 MATR3 SLIT3 SLIT3 NKX2-5 NKX2-5 PRDM1 PRDM1 HEY2 HEY2 NOS3 NOS3 NOTCH1 NOTCH1 AP2B1 AP2B1 LOC736439 LOC736439 GATA3 GATA3 SALL1 SALL1 ENSPTRP00000064416 ENSPTRP00000064416 HES1 HES1 RBPJ RBPJ HOXA13 HOXA13 EGLN1 EGLN1 HECTD1 HECTD1 MDM4 MDM4 PROX1 PROX1 SOX4 SOX4 XIRP2 XIRP2 CNTRL CNTRL BMPR2 BMPR2 HOXA13-2 HOXA13-2 PDE2A PDE2A STRA6 STRA6 DCTN5 DCTN5 NPRL3 NPRL3 ENSPTRP00000078044 ENSPTRP00000078044 ENSPTRP00000076988 ENSPTRP00000076988 SALL4 SALL4 GATA4 GATA4 ACVR1 ACVR1 TGFBR2 TGFBR2 ZFPM2 ZFPM2 ROBO1 ROBO1 SUFU SUFU TGFBR1 TGFBR1 ENSPTRP00000069764 ENSPTRP00000069764 HEY1 HEY1 TBX5 TBX5 LUZP1 LUZP1 TGFBR3 TGFBR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
LMO4LIM domain only 4. (165 aa)
RBM15RNA binding motif protein 15. (977 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TBX3T-box transcription factor 3. (743 aa)
PAX8PAX8 isoform 1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (504 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
SOX11Transcription factor SOX. (441 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
CK820_G0054677NPRL3 isoform 10. (74 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
LRP2LRP2 isoform 1. (4655 aa)
HEG1HEG1 isoform 1. (1381 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
MATR3MATR3 isoform 14. (895 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
PRDM1PR/SET domain 1. (825 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AP2B1AP complex subunit beta. (951 aa)
LOC736439AP-2 complex subunit beta pseudogene. (893 aa)
GATA3GATA binding protein 3. (444 aa)
SALL1SALL1 isoform 2. (1326 aa)
ENSPTRP00000064416annotation not available (502 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
HOXA13Homeobox A13. (388 aa)
EGLN1EGLN1 isoform 1. (426 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
PROX1Prospero homeobox 1. (737 aa)
SOX4Transcription factor SOX. (474 aa)
XIRP2XIRP2 isoform 3. (3549 aa)
CNTRLCentrosomal protein 110kDa. (2325 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
PDE2APhosphodiesterase. (941 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
DCTN5Dynactin subunit 5. (182 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
ENSPTRP00000078044annotation not available (170 aa)
ENSPTRP00000076988annotation not available (871 aa)
SALL4SALL4 isoform 1. (1053 aa)
GATA4GATA binding protein 4. (443 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENSPTRP00000069764annotation not available (1213 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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