STRINGSTRING
MEN1 MEN1 SIDT2 SIDT2 GDF11 GDF11 PDX1 PDX1 BMP4 BMP4 GATA6 GATA6 NKX2-2 NKX2-2 NKX6-1 NKX6-1 BMP6 BMP6 BMP5 BMP5 RFX6 RFX6 DLL1 DLL1 CDK6 CDK6 BHLHA15 BHLHA15 PAX4 PAX4 SMO SMO PAX6 PAX6 SMO-2 SMO-2 BHLHA15-2 BHLHA15-2 ONECUT1 ONECUT1 BMP4-2 BMP4-2 WNT5A WNT5A RFX3 RFX3 HNF4A HNF4A PDPK1 PDPK1 CDH2 CDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEN1MEN1 isoform 14. (615 aa)
SIDT2SID1 transmembrane family member 2 isoform X7. (854 aa)
GDF11GDF11 isoform 1. (407 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GATA6GATA binding protein 6. (594 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
RFX6RFX6 isoform 1. (928 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
PAX4PAX4 isoform 1. (351 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
PAX6PAX6 isoform 13. (436 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
BHLHA15-2Basic helix-loop-helix family member a15. (189 aa)
ONECUT1One cut domain family member. (465 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RFX3RFX3 isoform 4. (761 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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