32 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SOX8	SOX8 isoform 1. (446 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	FOXJ1	FOXJ1 isoform 1. (421 aa)
	SIX2	SIX homeobox 2. (291 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	CALB1	CALB1 isoform 3. (261 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (4012 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	KIF26B	KIF26B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
	LHX1	LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	FMN1	FMN1 isoform 1. (1425 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	SALL1	SALL1 isoform 2. (1326 aa)
	CK820_G0056924	NPIPA2 isoform 1. (277 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	ENSPTRP00000069764	annotation not available (1213 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CK820_G0054628	PKD1 isoform 4. (3384 aa)
	PAX8	PAX8 isoform 1. (456 aa)
	WT1	WT1 transcription factor. (514 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	LGR4	LGR4 isoform 2. (951 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSPTRP00000010780	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	SOX9	ENSPTRP00000010780	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4-2	CTNNB1	ENSPTRP00000080656	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4-2	FGF10	ENSPTRP00000080656	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4-2	SOX9	ENSPTRP00000080656	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
CK820_G0054628	CK820_G0056924	ENSPTRP00000083743	ENSPTRP00000064672	PKD1 isoform 4.	NPIPA2 isoform 1.	0.444
CK820_G0054628	CTNNB1	ENSPTRP00000083743	ENSPTRP00000044466	PKD1 isoform 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.599
CK820_G0054628	PKD2	ENSPTRP00000083743	ENSPTRP00000027941	PKD1 isoform 4.	Polycystin 2, transient receptor potential cation channel.	0.997
CK820_G0056924	CK820_G0054628	ENSPTRP00000064672	ENSPTRP00000083743	NPIPA2 isoform 1.	PKD1 isoform 4.	0.444
CK820_G0056924	CTNNB1	ENSPTRP00000064672	ENSPTRP00000044466	NPIPA2 isoform 1.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.503
CK820_G0056924	PKD2	ENSPTRP00000064672	ENSPTRP00000027941	NPIPA2 isoform 1.	Polycystin 2, transient receptor potential cation channel.	0.962
CTNNB1	BMP4	ENSPTRP00000044466	ENSPTRP00000010780	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Bone morphogenetic protein 4.	0.551
CTNNB1	BMP4-2	ENSPTRP00000044466	ENSPTRP00000080656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Bone morphogenetic protein 4.	0.551
CTNNB1	CK820_G0054628	ENSPTRP00000044466	ENSPTRP00000083743	Catenin (Cadherin-associated protein), beta 1, 88kDa.	PKD1 isoform 4.	0.599
CTNNB1	CK820_G0056924	ENSPTRP00000044466	ENSPTRP00000064672	Catenin (Cadherin-associated protein), beta 1, 88kDa.	NPIPA2 isoform 1.	0.503
CTNNB1	FGF10	ENSPTRP00000044466	ENSPTRP00000083399	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
CTNNB1	LGR4	ENSPTRP00000044466	ENSPTRP00000093566	Catenin (Cadherin-associated protein), beta 1, 88kDa.	LGR4 isoform 2.	0.532
CTNNB1	PDGFRB	ENSPTRP00000044466	ENSPTRP00000080188	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.504
CTNNB1	SMO	ENSPTRP00000044466	ENSPTRP00000033707	Catenin (Cadherin-associated protein), beta 1, 88kDa.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.479