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PMCHL1 PMCHL1 ENSPTRP00000087048 ENSPTRP00000087048 CALCB CALCB TTR TTR METRNL METRNL EPO-2 EPO-2 LHB LHB IGF2 IGF2 BMP10 BMP10 GPHB5 GPHB5 MLN MLN GHRL GHRL AGRP AGRP NPPA NPPA NPPB NPPB GAL GAL GPHA2 GPHA2 FSHB FSHB PTH PTH ADM ADM COPA COPA EDN2 EDN2 TSHB TSHB INSL5 INSL5 INS INS RETN RETN ENHO ENHO C1QTNF12 C1QTNF12 UTS2 UTS2 LEP LEP PRLH PRLH EDN3 EDN3 IGF1 IGF1 FBN1 FBN1 METRN METRN ENSPTRP00000067301 ENSPTRP00000067301 SST SST CK820_G0011608 CK820_G0011608 ADM2 ADM2 CALCA CALCA THPO THPO APELA APELA ENSPTRP00000061612 ENSPTRP00000061612 ERFE ERFE LOC107969785 LOC107969785 FNDC5 FNDC5 SPX SPX ANGPTL8 ANGPTL8 RLN1 RLN1 ENSPTRP00000054347 ENSPTRP00000054347 GH1-2 GH1-2 CK820_G0042350 CK820_G0042350 LOC452481 LOC452481 ENSPTRP00000052437 ENSPTRP00000052437 POMC POMC UCN3 UCN3 GCG GCG ENSPTRP00000048563 ENSPTRP00000048563 LOC107973292 LOC107973292 SCT SCT CARTPT CARTPT PYY PYY GUCA2A GUCA2A PTHLH PTHLH GALP GALP QRFP QRFP TOR2A TOR2A RLN2 RLN2 INSL4 INSL4 INSL6 INSL6 TG TG CRH CRH PENK PENK PNOC PNOC GNRH1 GNRH1 STC1 STC1 EPO EPO NPY NPY VIP VIP PRL PRL EDN1 EDN1 STC2 STC2 ADIPOQ ADIPOQ TRH TRH RETNLB RETNLB CCK CCK GHRH GHRH ASIP ASIP CHGB CHGB AVP AVP OXT OXT NPPC NPPC INHA INHA C2AH2orf40 C2AH2orf40 FNDC4 FNDC4 UCN UCN HAMP HAMP RLN3 RLN3 CCL25 CCL25 GRP GRP ADCYAP1 ADCYAP1 GH1 GH1 GIP GIP PPY PPY HCRT HCRT GAST GAST NMB NMB KL KL C1QTNF9 C1QTNF9 PMCH PMCH NTS NTS INHBE INHBE INHBC INHBC NPFF NPFF IAPP IAPP CORT CORT INHBB INHBB UTS2B UTS2B FBN2 FBN2 ENSPTRP00000092281 ENSPTRP00000092281 INHBA INHBA OSTN OSTN JAK3-2 JAK3-2 CGA CGA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMCHL1Pro-MCH variant; Belongs to the melanin-concentrating hormone family. (82 aa)
ENSPTRP00000087048annotation not available (82 aa)
CALCBCalcitonin related polypeptide beta. (138 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
METRNLMETRNL isoform 1. (273 aa)
EPO-2Erythropoietin. (193 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (157 aa)
IGF2Insulin like growth factor 2. (236 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
MLNMLN isoform 2. (118 aa)
GHRLGHRL isoform 10. (117 aa)
AGRPAgouti related neuropeptide. (132 aa)
NPPANatriuretic peptide A. (153 aa)
NPPBNatriuretic peptide B. (134 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
GPHA2Glycoprotein-alpha 2. (127 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
ADMAdrenomedullin. (185 aa)
COPACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1233 aa)
EDN2EDN2 isoform 1. (178 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
INSL5Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity). (135 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
RETNRETN isoform 1. (108 aa)
ENHOEnergy homeostasis associated. (76 aa)
C1QTNF12C1q and TNF related 12. (302 aa)
UTS2UTS2 isoform 2. (139 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PRLHProlactin releasing hormone. (87 aa)
EDN3EDN3 isoform 1. (238 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
FBN1FBN1 isoform 1. (2871 aa)
METRNMeteorin, glial cell differentiation regulator. (293 aa)
ENSPTRP00000067301annotation not available (92 aa)
SSTSST isoform 1. (116 aa)
CK820_G0011608CSH2 isoform 1. (199 aa)
ADM2ADM2 isoform 1. (127 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
THPOTHPO isoform 1. (353 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ENSPTRP00000061612annotation not available (208 aa)
ERFEERFE isoform 6. (353 aa)
LOC107969785T0149385 isoform 1. (331 aa)
FNDC5Fibronectin type III domain containing 5. (228 aa)
SPXChromosome 12 open reading frame 39. (116 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
RLN1Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family. (185 aa)
ENSPTRP00000054347annotation not available (161 aa)
GH1-2Chorionic somatomammotropin A2. (222 aa)
CK820_G0042350CGB7 isoform 1. (133 aa)
LOC452481C1QTNF9B isoform 3. (88 aa)
ENSPTRP00000052437Gonadotropin releasing hormone 2, pseudogene. (103 aa)
POMCProopiomelanocortin. (268 aa)
UCN3UCN3 isoform 1. (161 aa)
GCGGCG isoform 1. (180 aa)
ENSPTRP00000048563annotation not available (152 aa)
LOC107973292Choriogonadotropin subunit beta 7. (113 aa)
SCTSCT isoform 1. (125 aa)
CARTPTCART prepropeptide. (116 aa)
PYYPYY isoform 1. (95 aa)
GUCA2AGuanylate cyclase activator 2A. (115 aa)
PTHLHPTHLH isoform 7. (209 aa)
GALPGalanin like peptide. (116 aa)
QRFPQRFP isoform 1. (136 aa)
TOR2ATorsin. (321 aa)
RLN2Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. (185 aa)
INSL4Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. (139 aa)
INSL6Insulin-like peptide INSL6; May have a role in sperm development and fertilization. Belongs to the insulin family. (213 aa)
TGTG isoform 3. (2766 aa)
CRHCorticotropin releasing hormone. (196 aa)
PENKPENK isoform 3. (267 aa)
PNOCPrepronociceptin. (176 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
STC1Stanniocalcin 1. (247 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
NPYNeuropeptide Y. (97 aa)
VIPVasoactive intestinal peptide. (169 aa)
PRLPRL isoform 1. (227 aa)
EDN1EDN1 isoform 1. (212 aa)
STC2Stanniocalcin 2. (302 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
RETNLBResistin like beta. (111 aa)
CCKCCK isoform 2. (115 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ASIPAgouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (132 aa)
CHGBCHGB isoform 1. (677 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
NPPCNatriuretic peptide C. (126 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
C2AH2orf40Chromosome 2 open reading frame 40. (148 aa)
FNDC4Fibronectin type III domain containing 4. (234 aa)
UCNUCN isoform 1. (124 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
RLN3Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) (By similarity). (142 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
GRPGastrin releasing peptide. (138 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GH1Growth hormone variant; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. (271 aa)
GIPGastric inhibitory polypeptide. (153 aa)
PPYPancreatic polypeptide. (95 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
GASTGAST isoform 1. (101 aa)
NMBNMB isoform 1. (154 aa)
KLKL isoform 1. (1012 aa)
C1QTNF9C1QTNF9 isoform 1. (333 aa)
PMCHPro-MCH. (165 aa)
NTSNTS isoform 1. (170 aa)
INHBEInhibin subunit beta E. (350 aa)
INHBCInhibin subunit beta C. (352 aa)
NPFFPro-FMRFamide-related neuropeptide FF isoform X2. (113 aa)
IAPPIslet amyloid polypeptide. (89 aa)
CORTCENPS isoform 4. (143 aa)
INHBBInhibin subunit beta B. (407 aa)
UTS2BUrotensin 2 domain containing. (163 aa)
FBN2FBN2 isoform 1. (2912 aa)
ENSPTRP00000092281annotation not available (136 aa)
INHBAInhibin subunit beta A. (426 aa)
OSTNOSTN isoform 2. (133 aa)
JAK3-2Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). (156 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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