STRINGSTRING
STIM2 STIM2 TRPM8 TRPM8 CACNA1S CACNA1S CACNA2D4 CACNA2D4 GRIN2C GRIN2C CACNA2D1 CACNA2D1 CK820_G0010776 CK820_G0010776 ORAI2-2 ORAI2-2 PKD1L1-2 PKD1L1-2 SEC61A1 SEC61A1 TRPM2 TRPM2 CACNA1G CACNA1G TRPM1 TRPM1 PKD1L3 PKD1L3 CK820_G0056924 CK820_G0056924 RYR2 RYR2 GRIN2D GRIN2D PKD1L1 PKD1L1 TPCN2 TPCN2 CK820_G0042363 CK820_G0042363 TMEM37 TMEM37 TRPC4AP TRPC4AP GPM6A GPM6A CACNA1D CACNA1D MCU MCU CACNG4 CACNG4 ORAI3 ORAI3 ENSPTRP00000078278 ENSPTRP00000078278 ORAI2 ORAI2 LOC107966461-2 LOC107966461-2 CDK5 CDK5 ANXA6 ANXA6 CACNA1A CACNA1A TRPC1 TRPC1 CK820_G0054628 CK820_G0054628 ANXA2 ANXA2 TRPV4 TRPV4 TRPV5 TRPV5 CACNA1I CACNA1I CACNB4 CACNB4 GRIN2A GRIN2A TRPC3 TRPC3 MCOLN2 MCOLN2 CACNA2D3 CACNA2D3 GRIN3B GRIN3B ITGAV ITGAV CACNG8 CACNG8 PKD2L2 PKD2L2 TRPA1 TRPA1 TRPC4 TRPC4 CACNB2 CACNB2 OPRM1 OPRM1 TRPM5 TRPM5 TRPV6 TRPV6 TMC2 TMC2 TSPOAP1 TSPOAP1 MCOLN3 MCOLN3 ANXA9 ANXA9 TMCO1 TMCO1 CACNA1E CACNA1E PKD2L1 PKD2L1 CALHM1 CALHM1 CHRNA10 CHRNA10 CATSPER1 CATSPER1 PANX1 PANX1 TRPC6 TRPC6 CUL5 CUL5 CACNA1C CACNA1C GRIN2B GRIN2B TPCN1 TPCN1 P2RX4 P2RX4 ORAI1 ORAI1 RASA3 RASA3 PSEN1 PSEN1 CK820_G0025122 CK820_G0025122 CHRNA7 CHRNA7 LOC107966461 LOC107966461 SLC24A5 SLC24A5 TRPM7 TRPM7 SLC24A1 SLC24A1 CACNA1H CACNA1H CACNG3 CACNG3 TRPV3 TRPV3 TRPV1 TRPV1 TRPV2 TRPV2 CACNG5 CACNG5 CACNG1 CACNG1 MCOLN1 MCOLN1 TRPM4 TRPM4 CACNG7 CACNG7 ENSPTRP00000093907 ENSPTRP00000093907 RYR1 RYR1 CACNG6 CACNG6 SLC24A3 SLC24A3 CACNG2 CACNG2 RYR3 RYR3 CK820_G0030361 CK820_G0030361 TRPM3 TRPM3 CACNA2D2 CACNA2D2 TRPM6 TRPM6 CK820_G0034767 CK820_G0034767 CACNB3 CACNB3 CACNB1 CACNB1 PKDREJ PKDREJ ITPR2 ITPR2 ITPR1 ITPR1 CHRNA9 CHRNA9 PKD2 PKD2 CATSPER3 CATSPER3 TRPC7 TRPC7 ITPR3 ITPR3 TRPV5-2 TRPV5-2 SLC24A2 SLC24A2 CK820_G0008402 CK820_G0008402 TMC1 TMC1 GOLM1 GOLM1 NCS1 NCS1 CACNA1B CACNA1B CACFD1 CACFD1 CATSPER4 CATSPER4 CACHD1 CACHD1 CACNA1F CACNA1F TRPC5 TRPC5 GRIN3A GRIN3A GRIN1 GRIN1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STIM2STIM2 isoform 3. (841 aa)
TRPM8TRPM8 isoform 2. (1104 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CACNA2D4CACNA2D4 isoform 6. (1154 aa)
GRIN2CGRIN2C isoform 4. (1240 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CK820_G0010776TRPM8 isoform 5. (1112 aa)
ORAI2-2ORAI calcium release-activated calcium modulator 2. (262 aa)
PKD1L1-2Polycystin 1 like 1, transient receptor potential channel interacting. (2857 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1642 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1732 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
RYR2RYR2 isoform 1. (4941 aa)
GRIN2DGRIN2D isoform 1. (1265 aa)
PKD1L1PKD1L1 isoform 1. (2857 aa)
TPCN2Two pore segment channel 2. (752 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
TMEM37Transmembrane protein 37. (204 aa)
TRPC4APTransient receptor potential cation channel, subfamily C, member 4 associated protein. (797 aa)
GPM6AGlycoprotein M6A. (278 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MCUCoiled-coil domain containing 109A. (352 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (295 aa)
ENSPTRP00000078278annotation not available (260 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (262 aa)
LOC107966461-2Cation channel sperm-associated protein 2. (563 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
ANXA6Annexin. (788 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
ANXA2Annexin. (357 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5. (732 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2223 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
MCOLN2MCOLN2 isoform 1. (566 aa)
CACNA2D3CACNA2D3 isoform 3. (1091 aa)
GRIN3BGRIN3B isoform 1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1043 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (427 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1172 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6. (765 aa)
TMC2Transmembrane channel-like protein. (903 aa)
TSPOAP1TSPO associated protein 1. (1867 aa)
MCOLN3MCOLN3 isoform 1. (553 aa)
ANXA9Annexin. (309 aa)
TMCO1Transmembrane and coiled-coil domains 1. (239 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
CALHM1Calcium homeostasis modulator 1. (346 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
CATSPER1Cation channel sperm associated 1. (780 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
TRPC6Transient receptor potential cation channel, subfamily C, member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
CUL5CUL5 isoform 1; Belongs to the cullin family. (780 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
TPCN1TPCN1 isoform 2. (888 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
ORAI1ORAI1 isoform 1. (301 aa)
RASA3RAS p21 protein activator 3. (740 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CK820_G0025122SLC24A4 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (343 aa)
CHRNA7CHRNA7 isoform 7. (511 aa)
LOC107966461CATSPER2 isoform 1. (563 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (500 aa)
TRPM7Transient receptor potential cation channel, subfamily M, member 7. (1865 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1096 aa)
CACNA1HCACNA1H isoform 1. (2240 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
TRPV2Transient receptor potential cation channel, subfamily V, member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
MCOLN1MCOLN1 isoform 1. (601 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ENSPTRP00000093907annotation not available (528 aa)
RYR1RYR1 isoform 3. (5037 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
SLC24A3Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (644 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
RYR3Ryanodine receptor 3. (4873 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
TRPM3Transient receptor potential cation channel subfamily M member 3. (1711 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
TRPM6TRPM6 isoform 2. (2017 aa)
CK820_G0034767SEC61A2 isoform 11; Belongs to the SecY/SEC61-alpha family. (136 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (626 aa)
PKDREJPolycystin family receptor for egg jelly. (2251 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
TRPV5-2Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (661 aa)
CK820_G0008402Annexin. (233 aa)
TMC1Transmembrane channel-like protein. (760 aa)
GOLM1Golgi membrane protein 1. (404 aa)
NCS1Neuronal calcium sensor 1. (173 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2312 aa)
CACFD1Calcium channel flower domain containing 1. (233 aa)
CATSPER4Cation channel sperm associated 4. (464 aa)
CACHD1CACHD1 isoform 4. (1274 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
GRIN3AGRIN3A isoform 1. (1115 aa)
GRIN1Glutamate receptor, ionotropic, N-methyl D-aspartate 1. (845 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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