STRINGSTRING
SESN2 SESN2 ZNF692 ZNF692 SIRT1 SIRT1 DGAT2 DGAT2 NNMT NNMT CRY1 CRY1 FOXO1 FOXO1 SERPINA12 SERPINA12 KAT2A KAT2A PDK2 PDK2 SIRT7 SIRT7 STK11 STK11 SIRT6 SIRT6 EP300 EP300 PPARA PPARA KAT2B KAT2B ADIPOQ ADIPOQ PPARGC1A PPARGC1A NLN NLN NR3C1 NR3C1 GNMT GNMT FBP1 FBP1 GPT GPT GCK GCK FAM3C FAM3C SLC35B4 SLC35B4 SDHAF3 SDHAF3 GCG GCG MST1 MST1 CLK2 CLK2 ACADM ACADM LEPR LEPR ERFE ERFE SELENOS SELENOS PGP PGP LOC107975733 LOC107975733 ENSPTRP00000064845 ENSPTRP00000064845 ENSPTRP00000066334 ENSPTRP00000066334 OGT OGT ARPP19 ARPP19 FAM3A FAM3A WDR5 WDR5 LEP LEP PTPN2 PTPN2 C1QTNF12 C1QTNF12 USP7 USP7 SOGA1 SOGA1 PPP4R3B PPP4R3B DDB1 DDB1 DGKQ DGKQ ENSPTRP00000083257 ENSPTRP00000083257 ENSPTRP00000086305 ENSPTRP00000086305 ENSPTRP00000089297 ENSPTRP00000089297 SIRT1-2 SIRT1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN2SESN2 isoform 1. (480 aa)
ZNF692Zinc finger protein 692. (524 aa)
SIRT1SIRT1 isoform 2. (751 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
FOXO1FOXO1 isoform 1. (655 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SIRT7SIRT7 isoform 2. (400 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
SIRT6SIRT6 isoform 1. (355 aa)
EP300E1A binding protein p300. (2175 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
NLNNeurolysin (Metallopeptidase M3 family). (704 aa)
NR3C1NR3C1 isoform 5. (778 aa)
GNMTGlycine N-methyltransferase. (295 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
GCKPhosphotransferase. (466 aa)
FAM3CFamily with sequence similarity 3, member C. (227 aa)
SLC35B4Pleckstrin homology domain containing, family M, member 3. (331 aa)
SDHAF3Succinate dehydrogenase complex assembly factor 3. (125 aa)
GCGGCG isoform 1. (180 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
CLK2CDC-like kinase 2; Belongs to the protein kinase superfamily. (499 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (412 aa)
LEPRLeptin receptor. (1165 aa)
ERFEERFE isoform 6. (353 aa)
SELENOSSELENOS isoform 5. (218 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
LOC107975733Dual specificity protein kinase CLK2 pseudogene. (425 aa)
ENSPTRP00000064845annotation not available (112 aa)
ENSPTRP00000066334annotation not available (316 aa)
OGTOGT isoform 6. (1057 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
FAM3AFamily with sequence similarity 3 member A. (244 aa)
WDR5WD repeat domain 5. (334 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (421 aa)
C1QTNF12C1q and TNF related 12. (302 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1657 aa)
PPP4R3BSMEK homolog 2, suppressor of mek1 (Dictyostelium). (849 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
DGKQDiacylglycerol kinase. (952 aa)
ENSPTRP00000083257annotation not available (412 aa)
ENSPTRP00000086305annotation not available (425 aa)
ENSPTRP00000089297annotation not available (265 aa)
SIRT1-2Sirtuin 1. (751 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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