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| | MRTO4 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa) |
| | PPP1R8 | Protein phosphatase 1, regulatory (Inhibitor) subunit 8. (351 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | THRAP3 | Thyroid hormone receptor associated protein 3. (955 aa) |
| | MAGOH | Mago-nashi homolog, proliferation-associated. (146 aa) |
| | RBM8A | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1134 aa) |
| | SWT1 | Chromosome 1 open reading frame 26. (900 aa) |
| | UPF2 | UPF2 regulator of nonsense mediated mRNA decay. (1272 aa) |
| | SUPV3L1 | Suppressor of var1, 3-like 1. (786 aa) |
| | LRRC27 | LRRC27 isoform 3. (530 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | RBM7 | T0120761 isoform 1. (267 aa) |
| | ZPR1 | Zinc finger protein 259. (459 aa) |
| | SIDT2 | SID1 transmembrane family member 2 isoform X7. (854 aa) |
| | DCPS | Decapping enzyme, scavenger. (337 aa) |
| | DCP1B | DCP1B isoform 2. (621 aa) |
| | METTL3 | N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa) |
| | DIS3L | DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1054 aa) |
| | EDC3 | Enhancer of mRNA decapping 3 homolog. (508 aa) |
| | GSPT1 | G1 to S phase transition 1. (521 aa) |
| | PARN | PARN isoform 1. (639 aa) |
| | ERN2 | ERN2 isoform 1. (926 aa) |
| | CNOT1 | CCR4-NOT transcription complex, subunit 1. (2383 aa) |
| | EXOSC6 | Exosome complex component MTR3. (272 aa) |
| | SMG6 | SMG6 isoform 2. (1419 aa) |
| | SLFN13 | Schlafen family member 13. (898 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | SMG8 | T0071414 isoform 1. (991 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | CTIF | Cap binding complex dependent translation initiation factor. (600 aa) |
| | LSM7 | LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (176 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa) |
| | ZFP36 | Zinc finger protein 36, C3H type, homolog. (332 aa) |
| | SMG9 | SMG9 nonsense mediated mRNA decay factor. (520 aa) |
| | NANOS2 | Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa) |
| | RNASEH1 | T0034625 isoform 1. (286 aa) |
| | NBAS | Neuroblastoma amplified sequence. (2371 aa) |
| | CNOT11 | CCR4-NOT transcription complex subunit 11. (510 aa) |
| | POLR2D | Polymerase (RNA) II (DNA directed) polypeptide D. (142 aa) |
| | SSB | Small RNA binding exonuclease protection factor La. (408 aa) |
| | XRN2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa) |
| | HELZ2 | HELZ2 isoform 3. (2668 aa) |
| | MLH1 | MutL homolog 1, colon cancer, nonpolyposis type 2. (756 aa) |
| | EXOSC7 | Exosome component 7. (291 aa) |
| | PDE12 | Phosphodiesterase 12. (609 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1706 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6 like. (562 aa) |
| | HNRNPD | HNRNPD isoform 1. (356 aa) |
| | METTL14 | Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa) |
| | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | MTREX | Superkiller viralicidic activity 2-like 2. (1042 aa) |
| | TTC37 | Tetratricopeptide repeat domain 37. (1564 aa) |
| | CNOT8 | CCR4-NOT transcription complex, subunit 8. (292 aa) |
| | LSM2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | BCLAF1 | BCL2-associated transcription factor 1. (920 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa) |
| | CNOT4 | CCR4-NOT transcription complex subunit 4. (712 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (137 aa) |
| | POP1 | Processing of 1, ribonuclease P/MRP subunit. (1024 aa) |
| | EXOSC4 | Exosome component 4. (245 aa) |
| | EXOSC3 | Exosome complex exonuclease RRP40. (275 aa) |
| | RC3H2 | Ring finger and CCCH-type domains 2. (1191 aa) |
| | UPF3B | UPF3B regulator of nonsense mediated mRNA decay. (483 aa) |
| | DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1143 aa) |
| | SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) |
| | PABPC4 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa) |
| | SMG1 | SMG1 isoform 1; Belongs to the PI3/PI4-kinase family. (3610 aa) |
| | CNOT3 | CCR4-NOT transcription complex, subunit 3. (753 aa) |
| | SMG5 | Smg-5 homolog, nonsense mediated mRNA decay factor. (1016 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1401 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (887 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (700 aa) |
| | DICER1 | Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | SKIV2L | Superkiller viralicidic activity 2-like. (1246 aa) |
| | TENT2 | PAPD4 isoform 1. (484 aa) |
| | EXOSC5 | Exosome component 5. (235 aa) |
| | EXOSC2 | Exosome component 2. (293 aa) |
| | OAS2 | 2',5'-oligoadenylate synthetase 2. (719 aa) |
| | EXOSC1 | Exosome component 1. (195 aa) |
| | ZHX2 | Zinc fingers and homeoboxes 2. (837 aa) |
| | LSM1 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa) |
| | PABPN1L | Poly(A) binding protein nuclear 1 like, cytoplasmic. (278 aa) |
| | DIS3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa) |
| | EXOSC8 | Exosome component 8. (276 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (887 aa) |
| | CK820_G0055309 | Uncharacterized protein. (181 aa) |
| | RNASET2 | T0135877 isoform 1; Belongs to the RNase T2 family. (285 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | MTPAP | Mitochondrial poly(A) polymerase. (582 aa) |
| | CNOT2 | CCR4-NOT transcription complex, subunit 2. (550 aa) |
| | LOC749371 | Uncharacterized protein. (582 aa) |
| | ZCCHC7 | Zinc finger CCHC domain-containing protein 7. (543 aa) |
| | LOC745166 | HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa) |
| | SLFN12L | SLFN12L isoform 3. (610 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20kDa. (181 aa) |
| | PATL2 | Protein PAT1 homolog 2 isoform X2. (545 aa) |
| | CK820_G0038659 | CNOT7 isoform 10. (245 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1, 80kDa. (790 aa) |
| | WDR82 | WD repeat domain 82. (313 aa) |
| | EXOSC10 | EXOSC10 isoform 1. (869 aa) |
| | EXOSC9 | Exosome component 9. (456 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9. (331 aa) |
| | EIF4A3 | Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa) |
| | DNA2 | DNA2 isoform 3. (1024 aa) |
| | ETF1 | Eukaryotic translation termination factor 1. (423 aa) |
| | PATL1 | PAT1 homolog 1, processing body mRNA decay factor. (727 aa) |
| | ZC3H4 | ZC3H4 isoform 1. (1303 aa) |
| | ENSPTRP00000065777 | annotation not available (412 aa) |
| | CK820_G0037783 | LSM5 isoform 6. (87 aa) |
| | ZFP36L2 | Zinc finger protein 36, C3H type-like 2. (492 aa) |
| | RNPS1 | RNA binding protein with serine rich domain 1. (305 aa) |
| | METTL16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (589 aa) |
| | SAMD4B | Sterile alpha motif domain containing 4B. (694 aa) |
| | ENSPTRP00000068474 | annotation not available (308 aa) |
| | ENSPTRP00000068740 | annotation not available (675 aa) |
| | PABPC4L | PABPC4L isoform 1. (430 aa) |
| | ENSPTRP00000068968 | annotation not available (60 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1129 aa) |
| | UPF3A | UPF3A isoform 1. (476 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (599 aa) |
| | PABPC1 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa) |
| | CNOT6 | CCR4-NOT transcription complex, subunit 6. (557 aa) |
| | ENSPTRP00000069570 | annotation not available (316 aa) |
| | CASC3 | CASC3 exon junction complex subunit. (584 aa) |
| | SLFN12-2 | Schlafen family member 12. (579 aa) |
| | LOC736868 | Protein mago nashi homolog. (148 aa) |
| | LIN28B | LIN28B isoform 2. (258 aa) |
| | TUT4 | ZCCHC11 isoform 8. (1649 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | ETF1-2 | Eukaryotic translation termination factor 1. (381 aa) |
| | CNOT10 | CCR4-NOT transcription complex subunit 10. (804 aa) |
| | ENSPTRP00000072847 | annotation not available (263 aa) |
| | POLR2G | POLR2G isoform 2. (64 aa) |
| | EXOSC2-2 | Exosome component 2. (293 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa) |
| | LOC100612723 | Polyadenylate-binding protein 1 pseudogene. (281 aa) |
| | NOCT | CCR4 carbon catabolite repression 4-like. (431 aa) |
| | ENSPTRP00000076399 | annotation not available (125 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (469 aa) |
| | CK820_G0002104 | EIF3E isoform 7; Belongs to the eIF-3 subunit E family. (183 aa) |
| | ENSPTRP00000077268 | annotation not available (202 aa) |
| | CK820_G0043575 | RNPS1 isoform 21. (262 aa) |
| | ENSPTRP00000077946 | annotation not available (404 aa) |
| | CNOT7 | CCR4-NOT transcription complex, subunit 7. (285 aa) |
| | LOC100609987 | Lupus La protein pseudogene. (357 aa) |
| | EIF3E | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (496 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | SAMD4A | Sterile alpha motif domain containing 4A. (718 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (148 aa) |
| | ENSPTRP00000080573 | annotation not available (408 aa) |
| | LRPPRC | LRPPRC isoform 1. (1394 aa) |
| | ZCCHC8 | Zinc finger, CCHC domain containing 8. (707 aa) |
| | ENSPTRP00000081322 | annotation not available (396 aa) |
| | AGO1 | Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. (860 aa) |
| | ENSPTRP00000081975 | annotation not available (643 aa) |
| | RNASEH2C | Ribonuclease H2 subunit C. (247 aa) |
| | SMG5-2 | SMG5 nonsense mediated mRNA decay factor. (1038 aa) |
| | NBDY | Negative regulator of P-body association. (68 aa) |
| | LOC461988 | Bcl-2-associated transcription factor 1 pseudogene. (857 aa) |
| | TUT7 | ZCCHC6 isoform 2. (1540 aa) |
| | ENSPTRP00000083365 | annotation not available (381 aa) |
| | ENSPTRP00000083497 | Serine/threonine-protein kinase SMG1-like. (172 aa) |
| | LOC104005058 | RNA-binding protein 7 pseudogene. (250 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (784 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (527 aa) |
| | RNASEH2B | Ribonuclease H2, subunit B. (315 aa) |
| | KHSRP | KHSRP isoform 2. (747 aa) |
| | ENSPTRP00000085820 | annotation not available (199 aa) |
| | SMG7 | SMG7 nonsense mediated mRNA decay factor. (1178 aa) |
| | CNOT3-2 | CCR4-NOT transcription complex subunit 3. (753 aa) |
| | YTHDF2 | YTH N6-methyladenosine RNA binding protein 2. (595 aa) |
| | PNLDC1 | PARN like, ribonuclease domain containing 1. (531 aa) |
| | CK820_G0044476 | CNOT6 isoform 4. (464 aa) |
| | ENSPTRP00000087255 | annotation not available (1276 aa) |
| | CK820_G0006899 | DXO isoform 6. (396 aa) |
| | LIN28A | LIN28A isoform 1. (209 aa) |
| | DCP2 | DCP2 decapping enzyme homolog. (420 aa) |
| | PYM1 | PYM homolog 1, exon junction complex associated factor. (204 aa) |
| | NUDT16 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 16. (227 aa) |
| | ENSPTRP00000089329 | annotation not available (384 aa) |
| | LOC100611704 | Polyadenylate-binding protein 1 pseudogene. (294 aa) |
| | NUDT16P1 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 16. (206 aa) |
| | MAGOHB | Mago homolog B, exon junction complex subunit. (148 aa) |
| | ENSPTRP00000090045 | annotation not available (208 aa) |
| | SLFN12 | Schlafen family member 12. (579 aa) |
| | NUDT12 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12. (462 aa) |
| | ENSPTRP00000090981 | annotation not available (244 aa) |
| | ENSPTRP00000091556 | annotation not available (277 aa) |
| | LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa) |
| | ENSPTRP00000091865 | annotation not available (183 aa) |
| | DCP1A | DCP1 decapping enzyme homolog A. (582 aa) |
| | DXO | Dom-3 homolog Z. (396 aa) |
