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FRRS1 FRRS1 FLVCR1 FLVCR1 HPX HPX HEPHL1 HEPHL1 LOC738449 LOC738449 ATP6V0A2 ATP6V0A2 HIF1A HIF1A IREB2 IREB2 BOLA2B BOLA2B ATP6V0D1 ATP6V0D1 TMEM199 TMEM199 SMAD4 SMAD4 HAMP HAMP CYBRD1 CYBRD1 SLC40A1 SLC40A1 SLC11A1 SLC11A1 SOD1 SOD1 HMOX1 HMOX1 ATP6V1A ATP6V1A TF TF CP CP FTMT FTMT NCOA4 NCOA4 NDFIP1 NDFIP1 BMP6 BMP6 TFR2 TFR2 SCARA5 SCARA5 ACO1 ACO1 ATP6V1G1 ATP6V1G1 FTHL17 FTHL17 ATP6AP1 ATP6AP1 SLC22A17 SLC22A17 SLC39A8 SLC39A8 TFRC TFRC STEAP4 STEAP4 LCN2-2 LCN2-2 FTL FTL ENSPTRP00000060867 ENSPTRP00000060867 ERFE ERFE CCDC115 CCDC115 TMPRSS6 TMPRSS6 EGLN1 EGLN1 ENSPTRP00000062516 ENSPTRP00000062516 LOC101059804 LOC101059804 ENSPTRP00000063979 ENSPTRP00000063979 HEPH HEPH SLC39A14 SLC39A14 ENSPTRP00000064362 ENSPTRP00000064362 ABCB6 ABCB6 ENSPTRP00000068479 ENSPTRP00000068479 GDF2 GDF2 SLC46A1 SLC46A1 ENSPTRP00000070343 ENSPTRP00000070343 LCN2 LCN2 CYB561 CYB561 SLC11A2 SLC11A2 ENSPTRP00000072952 ENSPTRP00000072952 LOC100613627 LOC100613627 MYC MYC ENSPTRP00000075851 ENSPTRP00000075851 TTC7A TTC7A ABCB7 ABCB7 ALAS2 ALAS2 GLRX3 GLRX3 ENSPTRP00000078404 ENSPTRP00000078404 ENSPTRP00000079019 ENSPTRP00000079019 HFE HFE CYB561A3 CYB561A3 SRI SRI ENSPTRP00000080853 ENSPTRP00000080853 ISCU ISCU SRI-2 SRI-2 ATP13A2 ATP13A2 ENSPTRP00000082988 ENSPTRP00000082988 FTH1 FTH1 STEAP2 STEAP2 FXN FXN ENSPTRP00000084626 ENSPTRP00000084626 ENSPTRP00000084909 ENSPTRP00000084909 ENSPTRP00000085680 ENSPTRP00000085680 HJV HJV STEAP2-2 STEAP2-2 NUBP1 NUBP1 ENSPTRP00000089728 ENSPTRP00000089728 ENSPTRP00000089762 ENSPTRP00000089762 ENSPTRP00000090693 ENSPTRP00000090693 LOC101059049 LOC101059049 ENSPTRP00000091795 ENSPTRP00000091795 ENSPTRP00000092342 ENSPTRP00000092342 CK820_G0029100 CK820_G0029100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRRS1Ferric chelate reductase 1. (626 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
HEPHL1HEPHL1 isoform 1; Belongs to the multicopper oxidase family. (1159 aa)
LOC738449Iron-sulfur cluster scaffold homolog; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (177 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
IREB2Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
BOLA2BBOLA2-SMG1P6 isoform 3; Belongs to the BolA/IbaG family. (152 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
TMEM199Transmembrane protein 199. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
CYBRD1Cytochrome b reductase 1. (286 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A. (618 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
CPCP isoform 1; Belongs to the multicopper oxidase family. (1069 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (242 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
TFR2Transferrin receptor 2. (801 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (496 aa)
ACO1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (889 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
SLC22A17SLC22A17 isoform 1. (555 aa)
SLC39A8Solute carrier family 39 (Zinc transporter), member 8. (460 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
STEAP4STEAP4 metalloreductase. (459 aa)
LCN2-2LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
ENSPTRP00000060867annotation not available (175 aa)
ERFEERFE isoform 6. (353 aa)
CCDC115Coiled-coil domain containing 115. (193 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
EGLN1EGLN1 isoform 1. (426 aa)
ENSPTRP00000062516annotation not available (459 aa)
LOC101059804Ferritin heavy chain pseudogene. (150 aa)
ENSPTRP00000063979annotation not available (506 aa)
HEPHHEPH isoform 1; Belongs to the multicopper oxidase family. (1212 aa)
SLC39A14SLC39A14 isoform 1. (490 aa)
ENSPTRP00000064362annotation not available (543 aa)
ABCB6ATP-binding cassette, sub-family B (MDR/TAP), member 6. (854 aa)
ENSPTRP00000068479annotation not available (75 aa)
GDF2GDF2 isoform 1. (429 aa)
SLC46A1Solute carrier family 46 (Folate transporter), member 1. (459 aa)
ENSPTRP00000070343annotation not available (173 aa)
LCN2Lipocalin 2. (240 aa)
CYB561CYB561 isoform 16. (318 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
ENSPTRP00000072952annotation not available (212 aa)
LOC100613627Ferritin heavy chain pseudogene. (165 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
ENSPTRP00000075851annotation not available (171 aa)
TTC7ATetratricopeptide repeat domain 7A. (882 aa)
ABCB7ATP-binding cassette, sub-family B (MDR/TAP), member 7. (753 aa)
ALAS25-aminolevulinate synthase. (587 aa)
GLRX3GLRX3 isoform 1. (335 aa)
ENSPTRP00000078404annotation not available (801 aa)
ENSPTRP00000079019annotation not available (165 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
CYB561A3Cytochrome b561 family member A3. (259 aa)
SRISRI isoform 1. (205 aa)
ENSPTRP00000080853annotation not available (113 aa)
ISCUISCU isoform 5; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (154 aa)
SRI-2SRI isoform 5. (237 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1195 aa)
ENSPTRP00000082988annotation not available (168 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
STEAP2Six transmembrane epithelial antigen of the prostate 2. (490 aa)
FXNFXN isoform 1. (210 aa)
ENSPTRP00000084626annotation not available (113 aa)
ENSPTRP00000084909annotation not available (278 aa)
ENSPTRP00000085680annotation not available (88 aa)
HJVHFE2 isoform 1. (426 aa)
STEAP2-2STEAP2 metalloreductase. (490 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
ENSPTRP00000089728annotation not available (96 aa)
ENSPTRP00000089762annotation not available (77 aa)
ENSPTRP00000090693annotation not available (46 aa)
LOC101059049Ferritin heavy chain pseudogene. (173 aa)
ENSPTRP00000091795annotation not available (159 aa)
ENSPTRP00000092342annotation not available (158 aa)
CK820_G0029100SRI isoform 2. (98 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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