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SLC8A1 SLC8A1 ENSPTRP00000092784 ENSPTRP00000092784 CK820_G0029100 CK820_G0029100 NOS1 NOS1 ANKRD44 ANKRD44 SLC8A3 SLC8A3 ENSPTRP00000090392 ENSPTRP00000090392 CCN2 CCN2 ATP1A1 ATP1A1 SUMO1 SUMO1 CAMK2D CAMK2D TMEM38B TMEM38B ANKRD28 ANKRD28 KCNQ1 KCNQ1 GJA5 GJA5 ACTN3 ACTN3 ENSPTRP00000085903 ENSPTRP00000085903 SUMO1-3 SUMO1-3 ENSPTRP00000085680 ENSPTRP00000085680 TRPV4 TRPV4 ENSPTRP00000085085 ENSPTRP00000085085 DMD-2 DMD-2 ADRA1A ADRA1A SUMO1-2 SUMO1-2 EHD3 EHD3 CALM1 CALM1 ATP2A1 ATP2A1 ENSPTRP00000082718 ENSPTRP00000082718 ATP1A2 ATP1A2 MYH7 MYH7 ASB3 ASB3 SRI-2 SRI-2 SRI SRI MYL2 MYL2 BMP10 BMP10 PLN PLN GATA4 GATA4 TNNT3 TNNT3 STRIT1 STRIT1 DMD DMD SCN5A SCN5A ZC3H12A ZC3H12A DMPK DMPK PDE4D PDE4D FGF13 FGF13 SLC9A1 SLC9A1 DLG1 DLG1 PDE4B PDE4B CLIC2-2 CLIC2-2 ANKRD66 ANKRD66 AKAP9-2 AKAP9-2 RYR2 RYR2 ENSPTRP00000063671 ENSPTRP00000063671 GSTO1 GSTO1 CK820_G0042363 CK820_G0042363 ENSPTRP00000061732 ENSPTRP00000061732 KBTBD13 KBTBD13 ASPH ASPH RNF207 RNF207 TNNI3 TNNI3 AKAP9 AKAP9 CLIC2 CLIC2 ANK2 ANK2 PIK3CG PIK3CG PDE5A PDE5A SCN10A SCN10A NR4A1 NR4A1 ACE2 ACE2 STC1 STC1 CAV1 CAV1 DSP DSP NKX2-5 NKX2-5 ADRA1B ADRA1B MYL3 MYL3 CAV3 CAV3 BIN1 BIN1 UCN UCN FKBP1B FKBP1B TRPM4 TRPM4 HRC HRC CALM3 CALM3 TMEM38A TMEM38A PRKACA PRKACA SMAD7 SMAD7 DSG2 DSG2 DSC2 DSC2 KCNJ2 KCNJ2 SCN4A SCN4A JUP JUP RANGRF RANGRF HCN4 HCN4 CHGA CHGA P2RX4 P2RX4 ATP2A2 ATP2A2 PKP2 PKP2 CACNA1C CACNA1C GRK2 GRK2 MYBPC3 MYBPC3 CTNNA3 CTNNA3 MYBPH MYBPH TNNI1 TNNI1 RGS2 RGS2 ATP1B1 ATP1B1 CASQ1 CASQ1 CASQ2 CASQ2 TNNI3K TNNI3K NPPA NPPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ENSPTRP00000092784annotation not available (75 aa)
CK820_G0029100SRI isoform 2. (98 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ANKRD44ANKRD44 isoform 3. (1004 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSPTRP00000090392annotation not available (93 aa)
CCN2CTGF isoform 1. (349 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
SUMO1SUMO1 isoform 3. (146 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
TMEM38BTransmembrane protein 38B. (297 aa)
ANKRD28Ankyrin repeat domain 28. (1063 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
ENSPTRP00000085903annotation not available (98 aa)
SUMO1-3Small ubiquitin-related modifier. (98 aa)
ENSPTRP00000085680annotation not available (88 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSPTRP00000085085annotation not available (84 aa)
DMD-2Dystrophin. (643 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
SUMO1-2Small ubiquitin-related modifier. (82 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (553 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa)
ENSPTRP00000082718annotation not available (235 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ASB3Ankyrin repeat and SOCS box containing 3. (556 aa)
SRI-2SRI isoform 5. (237 aa)
SRISRI isoform 1. (205 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
GATA4GATA binding protein 4. (443 aa)
TNNT3Troponin T3, fast skeletal type. (269 aa)
STRIT1Small transmembrane regulator of ion transport 1. (35 aa)
DMDDMD isoform 3. (3685 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
DMPKDystrophia myotonica-protein kinase. (639 aa)
PDE4DPhosphodiesterase. (809 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
PDE4BPhosphodiesterase. (736 aa)
CLIC2-2Chloride intracellular channel 2. (247 aa)
ANKRD66Ankyrin repeat domain 66. (251 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
RYR2RYR2 isoform 1. (4941 aa)
ENSPTRP00000063671annotation not available (122 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ENSPTRP00000061732annotation not available (285 aa)
KBTBD13Kelch repeat and BTB domain containing 13. (458 aa)
ASPHASPH isoform 1. (762 aa)
RNF207Ring finger protein 207. (634 aa)
TNNI3TNNI3 isoform 2. (169 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
ANK2ANK2 isoform 1. (3957 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PDE5APhosphodiesterase. (875 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
STC1Stanniocalcin 1. (247 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
DSPDSP isoform 1. (2871 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
ADRA1BADRA1B isoform 3. (518 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
BIN1Bridging integrator 1. (597 aa)
UCNUCN isoform 1. (124 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
HRCHRC isoform 2. (693 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
DSG2DSG2 isoform 1. (1118 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
JUPJunction plakoglobin. (745 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
CHGACHGA isoform 1. (459 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PKP2PKP2 isoform 1. (837 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
MYBPHMyosin binding protein H. (477 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
RGS2Regulator of G-protein signaling 2, 24kDa. (211 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
TNNI3KTNNI3K isoform 2. (835 aa)
NPPANatriuretic peptide A. (153 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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