44 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A2M	Alpha-2-macroglobulin. (1474 aa)
	IL6R	Interleukin 6 receptor. (442 aa)
	APCS	Pentaxin. (223 aa)
	CRP	Pentaxin. (224 aa)
	SAA4	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
	SAA2	Serum amyloid A-2 protein. (122 aa)
	MRGPRX1	MAS related GPR family member X1; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	IL22	IL22 isoform 1. (179 aa)
	SERPINA3	Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3; Belongs to the serpin family. (423 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	AHSG	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family. (368 aa)
	TFR2	Transferrin receptor 2. (801 aa)
	ORM2	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family. (201 aa)
	ASS1	Argininosuccinate synthetase 1. (412 aa)
	FN1	FN1 isoform 1. (2477 aa)
	SERPINA1	Serpin family A member 1; Belongs to the serpin family. (418 aa)
	F8	Coagulation factor VIII; Belongs to the multicopper oxidase family. (2351 aa)
	TFRC	Transferrin receptor (P90, CD71). (760 aa)
	SAA1	LOW QUALITY PROTEIN: serum amyloid A-1 protein. (121 aa)
	PLSCR1	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
	REG3G	Regenerating islet-derived protein 3-gamma. (174 aa)
	CK820_G0040173	HP isoform 11. (376 aa)
	ENSPTRP00000062039	annotation not available (397 aa)
	SIGIRR	SIGIRR isoform 3. (488 aa)
	HP	HP isoform 15. (92 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	APOL2	Apolipoprotein L2. (449 aa)
	LOC461877	Argininosuccinate synthase pseudogene. (389 aa)
	LOC100609621	Argininosuccinate synthase pseudogene. (245 aa)
	ENSPTRP00000071015	annotation not available (408 aa)
	ENSPTRP00000073414	annotation not available (393 aa)
	ENSPTRP00000078404	annotation not available (801 aa)
	IL1RN	Interleukin-1. (180 aa)
	IL6-2	Interleukin 6. (234 aa)
	CEBPB	CCAAT/enhancer-binding protein. (347 aa)
	CD163	CD163 isoform 1. (1156 aa)
	ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4. (930 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (491 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	AHSG	ENSPTRP00000056596	ENSPTRP00000027036	Alpha-2-macroglobulin.	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	0.684
A2M	APCS	ENSPTRP00000056596	ENSPTRP00000002570	Alpha-2-macroglobulin.	Pentaxin.	0.429
A2M	CK820_G0040173	ENSPTRP00000056596	ENSPTRP00000055139	Alpha-2-macroglobulin.	HP isoform 11.	0.743
A2M	CRP	ENSPTRP00000056596	ENSPTRP00000002574	Alpha-2-macroglobulin.	Pentaxin.	0.539
A2M	F2	ENSPTRP00000056596	ENSPTRP00000006168	Alpha-2-macroglobulin.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.616
A2M	F8	ENSPTRP00000056596	ENSPTRP00000042755	Alpha-2-macroglobulin.	Coagulation factor VIII; Belongs to the multicopper oxidase family.	0.478
A2M	HAMP	ENSPTRP00000056596	ENSPTRP00000018553	Alpha-2-macroglobulin.	Hepcidin antimicrobial peptide.	0.678
A2M	HP	ENSPTRP00000056596	ENSPTRP00000067098	Alpha-2-macroglobulin.	HP isoform 15.	0.820
A2M	IL1A	ENSPTRP00000056596	ENSPTRP00000021189	Alpha-2-macroglobulin.	Interleukin-1; Belongs to the IL-1 family.	0.462
A2M	IL1B	ENSPTRP00000056596	ENSPTRP00000021191	Alpha-2-macroglobulin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.820
A2M	IL6	ENSPTRP00000056596	ENSPTRP00000068252	Alpha-2-macroglobulin.	Interleukin 6 (Interferon, beta 2).	0.662
A2M	IL6-2	ENSPTRP00000056596	ENSPTRP00000080270	Alpha-2-macroglobulin.	Interleukin 6.	0.662
A2M	ORM2	ENSPTRP00000056596	ENSPTRP00000036363	Alpha-2-macroglobulin.	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family.	0.679
A2M	SERPINA1	ENSPTRP00000056596	ENSPTRP00000042361	Alpha-2-macroglobulin.	Serpin family A member 1; Belongs to the serpin family.	0.869
A2M	SERPINA3	ENSPTRP00000056596	ENSPTRP00000011398	Alpha-2-macroglobulin.	Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3; Belongs to the serpin family.	0.714
A2M	SERPINF2	ENSPTRP00000056596	ENSPTRP00000090784	Alpha-2-macroglobulin.	Serpin family F member 2; Belongs to the serpin family.	0.790
AHSG	A2M	ENSPTRP00000027036	ENSPTRP00000056596	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	Alpha-2-macroglobulin.	0.684
AHSG	CK820_G0040173	ENSPTRP00000027036	ENSPTRP00000055139	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	HP isoform 11.	0.644
AHSG	CRP	ENSPTRP00000027036	ENSPTRP00000002574	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	Pentaxin.	0.622
AHSG	F2	ENSPTRP00000027036	ENSPTRP00000006168	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.977