STRINGSTRING
FMOD FMOD ZFYVE9 ZFYVE9 BMP8B BMP8B ENSPTRP00000000998 ENSPTRP00000000998 SKI SKI ATF2 ATF2 COMP COMP SMAD9 SMAD9 MAP3K7 MAP3K7 ID1 ID1 ENSPTRP00000060416 ENSPTRP00000060416 EID2 EID2 CAV2 CAV2 ENSPTRP00000061448 ENSPTRP00000061448 CK820_G0012168 CK820_G0012168 TMPRSS6 TMPRSS6 SMAD2 SMAD2 HES1 HES1 RGMA RGMA ENSPTRP00000064416 ENSPTRP00000064416 TGFBR3L TGFBR3L NUP93 NUP93 RUNX2 RUNX2 TGFBR3 TGFBR3 LTBP2 LTBP2 LOC452254 LOC452254 ATOH8 ATOH8 SOSTDC1 SOSTDC1 LRRC32 LRRC32 USP9X USP9X ETV2 ETV2 GDF2 GDF2 DUSP22 DUSP22 GLG1 GLG1 SKIL SKIL SPTBN1 SPTBN1 PXN PXN TGFBRAP1 TGFBRAP1 ABL1 ABL1 TGFBR1 TGFBR1 SCX SCX AKAP4 AKAP4 USP15 USP15 ONECUT1 ONECUT1 ITGB6 ITGB6 PXN-2 PXN-2 FLCN FLCN NCEH1 NCEH1 TGFBR2 TGFBR2 ENSPTRP00000075374 ENSPTRP00000075374 ACVR1 ACVR1 NOTCH2 NOTCH2 GDF6 GDF6 HIVEP1 HIVEP1 PPARG PPARG SRC SRC ENSPTRP00000076822 ENSPTRP00000076822 ACVR2B ACVR2B LNPEP LNPEP BMP10 BMP10 FOS FOS PTPRK PTPRK ENSPTRP00000079019 ENSPTRP00000079019 HFE HFE LEFTY1 LEFTY1 TGFB1I1 TGFB1I1 LEF1 LEF1 ZCCHC18 ZCCHC18 SMAD5 SMAD5 PDCD4 PDCD4 HES5-2 HES5-2 BMP4-2 BMP4-2 FERMT2 FERMT2 ONECUT2 ONECUT2 CITED2 CITED2 SUB1 SUB1 RGMB RGMB CHRDL1 CHRDL1 ITGB8 ITGB8 JADE2 JADE2 PTK2 PTK2 SPI1 SPI1 EGR1 EGR1 HNF1A HNF1A ITGB8-2 ITGB8-2 GCNT2 GCNT2 GDF9-2 GDF9-2 WFIKKN2 WFIKKN2 BTBD11 BTBD11 ID1-2 ID1-2 ITGA8 ITGA8 HJV HJV CHRD CHRD WNT5A WNT5A NPNT NPNT HNF4A HNF4A TMEM100 TMEM100 SMURF2 SMURF2 ENSPTRP00000088702 ENSPTRP00000088702 SOSTDC1-2 SOSTDC1-2 CELF6-2 CELF6-2 SMAD3 SMAD3 INHBB INHBB PSG9 PSG9 STAT3 STAT3 LOC459608 LOC459608 ENSPTRP00000091683 ENSPTRP00000091683 LPXN LPXN TAB1 TAB1 CHST11 CHST11 ADAM9 ADAM9 SIRT1-2 SIRT1-2 INHBA INHBA NRROS NRROS AFP AFP BMP3 BMP3 BMPR1B BMPR1B SMAD1 SMAD1 SFRP2 SFRP2 HPGD HPGD FST FST GDF9 GDF9 BMP6 BMP6 MAPK14 MAPK14 BMP5 BMP5 TBXT TBXT BMPER BMPER MAGI2 MAGI2 COL1A2 COL1A2 DLX5 DLX5 HIPK2 HIPK2 ZYX ZYX FNTA FNTA EXT1 EXT1 FOXH1 FOXH1 ENG ENG BMP15 BMP15 CITED1 CITED1 ZCCHC12 ZCCHC12 USP9Y USP9Y HES5 HES5 SPART SPART GDF10 GDF10 DSG4 DSG4 SLC33A1 SLC33A1 LTBP1 LTBP1 SMURF1 SMURF1 BMPR2 BMPR2 PPM1L PPM1L ITGB5 ITGB5 FOXH1-2 FOXH1-2 SFRP1 SFRP1 MAPK3 MAPK3 MSX1 MSX1 TF TF APPL1 APPL1 TDGF1 TDGF1 ZNF831 ZNF831 BMP7 BMP7 TGIF2 TGIF2 GDF5 GDF5 BMP2 BMP2 INHA INHA MSTN MSTN COL3A1 COL3A1 ACVR1C ACVR1C ACVR2A ACVR2A CCDC142 CCDC142 GDF7 GDF7 ZNF8 ZNF8 MEGF8 MEGF8 TGFB1 TGFB1 LTBP4 LTBP4 FKBP8 FKBP8 GDF15 GDF15 AMH AMH SMAD4 SMAD4 SMAD7 SMAD7 TWSG1 TWSG1 DDX5 DDX5 MTMR4 MTMR4 NOG NOG DLX3 DLX3 SOST SOST NLK NLK FAM83G FAM83G TP53 TP53 ARRB2 ARRB2 SMPD3 SMPD3 CDH5 CDH5 STUB1 STUB1 FURIN FURIN PML PML SMAD6 SMAD6 RNF111 RNF111 TGFB3 TGFB3 FUT8 FUT8 BMP4 BMP4 FGF9 FGF9 APPL2 APPL2 INHBE INHBE INHBC INHBC SLC39A5 SLC39A5 GDF11 GDF11 AMHR2 AMHR2 ACVR1B ACVR1B ACVRL1 ACVRL1 WNT1 WNT1 GDF3 GDF3 AKAP3 AKAP3 RBM4 RBM4 LTBP3 LTBP3 FSHB FSHB BMPR1A BMPR1A ZMIZ1 ZMIZ1 NODAL NODAL SIRT1 SIRT1 BAMBI BAMBI VIM VIM PARP1 PARP1 LEFTY2 LEFTY2 TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FMODFMOD isoform 1. (376 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
BMP8BBMP8B isoform 1. (402 aa)
ENSPTRP00000000998annotation not available (224 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
ENSPTRP00000060416annotation not available (127 aa)
EID2EP300 interacting inhibitor of differentiation 2. (236 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
ENSPTRP00000061448annotation not available (572 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
ENSPTRP00000064416annotation not available (502 aa)
TGFBR3LTGFBR3L isoform 1. (313 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (880 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
LOC452254LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 1-like. (863 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
ETV2ETV2 isoform 5. (370 aa)
GDF2GDF2 isoform 1. (429 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
GLG1Golgi glycoprotein 1. (1203 aa)
SKILSKI like proto-oncogene. (684 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2366 aa)
PXNPXN isoform 20. (1078 aa)
TGFBRAP1Transforming growth factor, beta receptor associated protein 1. (860 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
AKAP4A-kinase anchoring protein 4. (845 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ONECUT1One cut domain family member. (465 aa)
ITGB6ITGB6 isoform 3. (701 aa)
PXN-2PXN isoform 9. (1081 aa)
FLCNT0180863 isoform 1. (579 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (440 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ENSPTRP00000075374annotation not available (236 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GDF6Growth differentiation factor 6. (455 aa)
HIVEP1HIVEP1 isoform 1. (2718 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSPTRP00000076822annotation not available (142 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
LNPEPLeucyl/cystinyl aminopeptidase. (1102 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
ENSPTRP00000079019annotation not available (165 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
LEFTY1Left-right determination factor. (366 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ZCCHC18ZCCHC18 isoform 2. (377 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FERMT2Fermitin family member 2. (706 aa)
ONECUT2One cut domain family member. (504 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SUB1SUB1 regulator of transcription. (127 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (478 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
JADE2Jade family PHD finger 2. (834 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
HNF1AHNF1 homeobox A. (662 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group). (402 aa)
GDF9-2Growth differentiation factor 9. (455 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
BTBD11BTB domain containing 11. (1101 aa)
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NPNTNPNT isoform 10. (611 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
TMEM100Transmembrane protein 100. (134 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
ENSPTRP00000088702annotation not available (170 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
CELF6-2CUGBP Elav-like family member 6 isoform X1. (538 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
INHBBInhibin subunit beta B. (407 aa)
PSG9Pregnancy-specific beta-1-glycoprotein 9 isoform X1. (426 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
LOC459608CFC1B isoform 2. (223 aa)
ENSPTRP00000091683annotation not available (342 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (391 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
SIRT1-2Sirtuin 1. (751 aa)
INHBAInhibin subunit beta A. (426 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (622 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
FSTFST isoform 1. (344 aa)
GDF9Growth differentiation factor 9. (455 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TBXTT-box transcription factor T. (435 aa)
BMPERBMP binding endothelial regulator. (685 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
DLX5Distal-less homeobox 5. (289 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
ZYXZYX isoform 1. (572 aa)
FNTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. (386 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FOXH1FOXH1 isoform 1. (365 aa)
ENGENG isoform 1. (658 aa)
BMP15BMP15 isoform 1. (369 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
USP9YUSP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
SLC33A1Solute carrier family 33 (Acetyl-CoA transporter), member 1. (549 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
PPM1LProtein phosphatase, Mg2+/Mn2+ dependent 1L. (360 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
FOXH1-2Forkhead box H1. (365 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
APPL1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
ZNF831Zinc finger protein 831. (1679 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
GDF7Growth differentiation factor 7. (447 aa)
ZNF8KRAB domain-containing zinc finger protein. (575 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
GDF15Growth differentiation factor 15. (308 aa)
AMHAnti-Mullerian hormone. (560 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DLX3Distal-less homeobox 3. (287 aa)
SOSTSOST isoform 1. (213 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
FAM83GFamily with sequence similarity 83, member G. (823 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ARRB2ARRB2 isoform 2. (430 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
PMLPML isoform 6. (836 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
RNF111RNF111 isoform 5. (1003 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (575 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
INHBEInhibin subunit beta E. (350 aa)
INHBCInhibin subunit beta C. (352 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
GDF11GDF11 isoform 1. (407 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF3Growth differentiation factor 3. (364 aa)
AKAP3A-kinase anchoring protein 3. (858 aa)
RBM4RNA-binding protein 14. (669 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
NODALNODAL isoform 2. (347 aa)
SIRT1SIRT1 isoform 2. (751 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
LEFTY2Left-right determination factor. (366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]