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PTHLH PTHLH CHGA CHGA ADCY9 ADCY9 ADORA2B ADORA2B RAMP2 RAMP2 GIP GIP GNA13 GNA13 SLC9A3R1 SLC9A3R1 GALR2 GALR2 ADCYAP1 ADCYAP1 MC4R MC4R GALR1 GALR1 ADGRE1 ADGRE1 ADGRL1 ADGRL1 PTRHD1 PTRHD1 ADCY3 ADCY3 ADGRF3 ADGRF3 LHCGR LHCGR FSHR FSHR RAMP1 RAMP1 ADRA1D ADRA1D GHRH GHRH ADORA2A ADORA2A PTH1R PTH1R GNAI2 GNAI2 ADCY5 ADCY5 GPR78 GPR78 PF4 PF4 CXCL9 CXCL9 CXCL10 CXCL10 CXCL11 CXCL11 PTGER4 PTGER4 ADRB2 ADRB2 ADRA1B ADRA1B GLP1R GLP1R ADGRF2 ADGRF2 ADGRB3 ADGRB3 GPR6 GPR6 VIP VIP RAMP3 RAMP3 ADCY1 ADCY1 HTR5A HTR5A ADGRD2 ADGRD2 GPR101 GPR101 LPAR2 LPAR2 ADGRG5 ADGRG5 AKAP13 AKAP13 ADRB3 ADRB3 ADGRG6 ADGRG6 CNR2 CNR2 GPR119 GPR119 RXFP1 RXFP1 ADGRE5 ADGRE5 GCG GCG GNAQ GNAQ UCN3 UCN3 PTGFR PTGFR GPR157 GPR157 DRD5 DRD5 ADGRG1 ADGRG1 S1PR3 S1PR3 GCGR GCGR GNAS GNAS ADRA2C ADRA2C S1PR2 S1PR2 ADRA2B ADRA2B ADRA2A ADRA2A S1PR1 S1PR1 CALCRL CALCRL GIPR GIPR RAPGEF4 RAPGEF4 TBXA2R TBXA2R DRD3 DRD3 ABCA1 ABCA1 ADCY7 ADCY7 LOC104003639 LOC104003639 LPAR1 LPAR1 GHRHR GHRHR CALCA CALCA ADM2 ADM2 ADGRE2 ADGRE2 ADCY1-2 ADCY1-2 GNG2 GNG2 DRD1 DRD1 GNB1 GNB1 PDE4D PDE4D ADGRG7 ADGRG7 TCP11 TCP11 ENSPTRP00000068511 ENSPTRP00000068511 DRD2 DRD2 ADGRL2 ADGRL2 ADGRD1 ADGRD1 ADGRG2 ADGRG2 HTR5A-2 HTR5A-2 CALCR CALCR GHRHR-2 GHRHR-2 GPR65 GPR65 ENSPTRP00000074765 ENSPTRP00000074765 PTGER3 PTGER3 ADGRE3 ADGRE3 ENSPTRP00000075783 ENSPTRP00000075783 RIT2 RIT2 PLN PLN ADGRF5 ADGRF5 GNAL GNAL GPR12 GPR12 ENSPTRP00000077377 ENSPTRP00000077377 ADCY8 ADCY8 GPHB5 GPHB5 ADGRB1 ADGRB1 GPR3 GPR3 ADGRL3 ADGRL3 RAPGEF2 RAPGEF2 LOC465127 LOC465127 GPR4 GPR4 ADGRL4 ADGRL4 ADCY2 ADCY2 CALCB CALCB ADGRG3 ADGRG3 ADRA1A ADRA1A MC2R MC2R GPR26 GPR26 PTGER1 PTGER1 ADGRE5-2 ADGRE5-2 ENSPTRP00000087978 ENSPTRP00000087978 GPR161 GPR161 ADGRF1 ADGRF1 ENSPTRP00000090301 ENSPTRP00000090301 TSHR TSHR PTGIR PTGIR ADGRG4 ADGRG4 ADCY6 ADCY6 LPAR3 LPAR3 CHRM3 CHRM3 ADRB1 ADRB1 ADM ADM PTH PTH GPHA2 GPHA2 IAPP IAPP TMEM116 TMEM116 RXFP2 RXFP2 ADCY4 ADCY4 PTGER2 PTGER2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTHLHPTHLH isoform 7. (209 aa)
CHGACHGA isoform 1. (459 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
RAMP2Receptor (G protein-coupled) activity modifying protein 2. (175 aa)
GIPGastric inhibitory polypeptide. (153 aa)
GNA13Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
MC4RMelanocortin 4 receptor. (332 aa)
GALR1Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
ADGRE1ADGRE1 isoform 4; Belongs to the G-protein coupled receptor 2 family. (941 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1477 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADGRF3Adhesion G protein-coupled receptor F3; Belongs to the G-protein coupled receptor 2 family. (1079 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
RAMP1Receptor (G protein-coupled) activity modifying protein 1. (148 aa)
ADRA1DADRA1D isoform 1. (568 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GPR78GPR78 isoform 4. (363 aa)
PF4C-X-C motif chemokine. (101 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CXCL10C-X-C motif chemokine. (96 aa)
CXCL11C-X-C motif chemokine. (94 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
ADRA1BADRA1B isoform 3. (518 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
ADGRF2Adhesion G protein-coupled receptor F4; Belongs to the G-protein coupled receptor 2 family. (752 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
GPR6G protein-coupled receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
VIPVasoactive intestinal peptide. (169 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
ADGRD2ADGRD2 isoform 1; Belongs to the G-protein coupled receptor 2 family. (952 aa)
GPR101G protein-coupled receptor 101; Belongs to the G-protein coupled receptor 1 family. (508 aa)
LPAR2Lysophosphatidic acid receptor 2. (351 aa)
ADGRG5ADGRG5 isoform 2; Belongs to the G-protein coupled receptor 2 family. (528 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
ADRB3ADRB3 isoform 1. (408 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
RXFP1RXFP1 isoform 5. (779 aa)
ADGRE5Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (840 aa)
GCGGCG isoform 1. (180 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
UCN3UCN3 isoform 1. (161 aa)
PTGFRProstaglandin F receptor (FP); Belongs to the G-protein coupled receptor 1 family. (359 aa)
GPR157G protein-coupled receptor 157. (335 aa)
DRD5D(1B) dopamine receptor. (477 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (350 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (480 aa)
GNASGNAS isoform 19. (1042 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (374 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ADRA2BAdrenoceptor alpha 2B. (448 aa)
ADRA2AAdrenergic, alpha-2A-, receptor. (465 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CALCRLCALCRL isoform 1; Belongs to the G-protein coupled receptor 2 family. (478 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
RAPGEF4RAPGEF4 isoform 2. (1011 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
DRD3D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). (400 aa)
ABCA1ATP-binding cassette, sub-family A (ABC1), member 1. (2264 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ADM2ADM2 isoform 1. (127 aa)
ADGRE2Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (833 aa)
ADCY1-2Adenylate cyclase 1. (1119 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
PDE4DPhosphodiesterase. (809 aa)
ADGRG7Adhesion G protein-coupled receptor G7; Belongs to the G-protein coupled receptor 2 family. (797 aa)
TCP11TCP11 isoform 10. (441 aa)
ENSPTRP00000068511annotation not available (353 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
ADGRL2ADGRL2 isoform 14; Belongs to the G-protein coupled receptor 2 family. (1480 aa)
ADGRD1ADGRD1 isoform 6; Belongs to the G-protein coupled receptor 2 family. (869 aa)
ADGRG2Adhesion G protein-coupled receptor G2; Belongs to the G-protein coupled receptor 2 family. (1017 aa)
HTR5A-25-hydroxytryptamine receptor 5A. (357 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
GHRHR-2Growth hormone-releasing hormone receptor isoform X1. (447 aa)
GPR65G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (337 aa)
ENSPTRP00000074765annotation not available (537 aa)
PTGER3Prostaglandin E receptor 3. (418 aa)
ADGRE3Adhesion G protein-coupled receptor E3; Belongs to the G-protein coupled receptor 2 family. (652 aa)
ENSPTRP00000075783annotation not available (149 aa)
RIT2Ras like without CAAX 2. (217 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
GNALG protein subunit alpha L. (458 aa)
GPR12G protein-coupled receptor 12; Belongs to the G-protein coupled receptor 1 family. (334 aa)
ENSPTRP00000077377annotation not available (149 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1612 aa)
GPR3G protein-coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (330 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1580 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
LOC465127Dopamine receptor D5 pseudogene. (432 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ADGRL4EGF, latrophilin and seven transmembrane domain containing 1; Belongs to the G-protein coupled receptor 2 family. (691 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CALCBCalcitonin related polypeptide beta. (138 aa)
ADGRG3Adhesion G protein-coupled receptor G3; Belongs to the G-protein coupled receptor 2 family. (549 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
MC2RMelanocortin 2 receptor. (297 aa)
GPR26G protein-coupled receptor 26. (337 aa)
PTGER1Prostaglandin E receptor 1. (402 aa)
ADGRE5-2Adhesion G protein-coupled receptor E5. (854 aa)
ENSPTRP00000087978annotation not available (470 aa)
GPR161GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family. (543 aa)
ADGRF1ADGRF1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (910 aa)
ENSPTRP00000090301annotation not available (443 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
PTGIRProstaglandin I2 (Prostacyclin) receptor (IP). (386 aa)
ADGRG4Adhesion G protein-coupled receptor G4; Belongs to the G-protein coupled receptor 2 family. (3078 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
LPAR3Lysophosphatidic acid receptor 3. (353 aa)
CHRM3Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). (590 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
ADMAdrenomedullin. (185 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
GPHA2Glycoprotein-alpha 2. (127 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TMEM116Transmembrane protein 116. (337 aa)
RXFP2Relaxin family peptide receptor 2. (754 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PTGER2Prostaglandin E receptor 2 (Subtype EP2), 53kDa; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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