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| | CFAP58 | Cilia and flagella associated protein 58. (872 aa) |
| | HES3 | HES3 isoform 1. (185 aa) |
| | SPEN | Spen family transcriptional repressor. (3662 aa) |
| | NR0B2 | Nuclear receptor subfamily 0 group B member 2. (257 aa) |
| | RBM15 | RNA binding motif protein 15. (977 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | DTX4 | Deltex E3 ubiquitin ligase 4. (619 aa) |
| | MAML2 | Mastermind like transcriptional coactivator 2. (1150 aa) |
| | NRIP2 | Nuclear receptor interacting protein 2. (281 aa) |
| | KCNA5 | Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | DTX1 | Deltex E3 ubiquitin ligase 1. (620 aa) |
| | RITA1 | RBPJ interacting and tubulin associated 1. (293 aa) |
| | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa) |
| | ADAM10 | ADAM metallopeptidase domain 10. (748 aa) |
| | APH1B | Aph-1 homolog B, gamma-secretase subunit. (257 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (268 aa) |
| | MESP2 | Mesoderm posterior bHLH transcription factor 2. (389 aa) |
| | TRAF7 | TNF receptor-associated factor 7. (670 aa) |
| | ZNF423 | Zinc finger protein 423. (1284 aa) |
| | TBX2 | T-box transcription factor 2. (712 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa) |
| | NOTCH3 | NOTCH3 isoform 1. (2321 aa) |
| | PSENEN | T0105581 isoform 1. (101 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | EPN1 | EPN1 isoform 5. (662 aa) |
| | ANXA4 | Annexin. (321 aa) |
| | DLX2 | Distal-less homeobox 2. (328 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (367 aa) |
| | ANGPT4 | ANGPT4 isoform 1. (503 aa) |
| | BMP2 | Bone morphogenetic protein 2. (398 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | POFUT1 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (388 aa) |
| | TIMP4 | TIMP metallopeptidase inhibitor 4. (224 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (740 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | GSX2 | GSX2 isoform 2. (304 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (707 aa) |
| | SORBS2 | Sorbin and SH3 domain containing 2. (1202 aa) |
| | GMDS | GDP-mannose 4,6-dehydratase. (372 aa) |
| | IL17A | IL17A isoform 1. (155 aa) |
| | HEY2 | Hairy/enhancer-of-split related with YRPW motif 2. (337 aa) |
| | ENSPTRP00000031829 | annotation not available (188 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) |
| | DTX2 | Deltex E3 ubiquitin ligase 2. (622 aa) |
| | CK820_G0055465 | RING-type domain-containing protein. (511 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | IFT74 | Intraflagellar transport 74 homolog. (600 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2555 aa) |
| | DLX1 | Distal-less homeobox 1. (255 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (165 aa) |
| | KRT19 | KRT19 isoform 1; Belongs to the intermediate filament family. (400 aa) |
| | CDH6 | Cadherin 6, type 2, K-cadherin (Fetal kidney); Cadherins are calcium-dependent cell adhesion proteins. (790 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | NKAP | NFKB activating protein. (415 aa) |
| | DNER | Delta/notch-like EGF repeat containing. (739 aa) |
| | CFD | Complement factor D. (253 aa) |
| | RIPPLY2 | Ripply transcriptional repressor 2. (128 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa) |
| | ADAM17 | ADAM17 isoform 3. (999 aa) |
| | FOXC2 | Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa) |
| | ATOH1 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa) |
| | S1PR3 | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (350 aa) |
| | MAML1 | MAML1 isoform 1. (1016 aa) |
| | NOTCH4 | NOTCH4 isoform 3. (2006 aa) |
| | SUSD5 | Sushi domain containing 5. (629 aa) |
| | ENSPTRP00000062011 | annotation not available (389 aa) |
| | NEUROD4 | Neurogenic differentiation factor. (331 aa) |
| | CK820_G0056543 | DTX2P1-UPK3BP1-PMS2P11 isoform 2. (590 aa) |
| | FOXA1 | FOXA1 isoform 1. (471 aa) |
| | MIB2 | Mindbomb homolog 2. (991 aa) |
| | PTP4A3 | Protein tyrosine phosphatase type IVA, member 3. (173 aa) |
| | CK820_G0054728 | MECP2 isoform 14. (493 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (478 aa) |
| | DLL3 | Delta like canonical Notch ligand 3. (618 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | GRIP2 | Glutamate receptor interacting protein 2. (1141 aa) |
| | FOXC1 | FOXC1 isoform 1. (550 aa) |
| | PGAM2-2 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (264 aa) |
| | GALNT11 | Polypeptide N-acetylgalactosaminyltransferase. (608 aa) |
| | ETV2 | ETV2 isoform 5. (370 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa) |
| | IFT172 | Intraflagellar transport 172 homolog. (1767 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | CNTN6 | CNTN6 isoform 1. (1028 aa) |
| | ONECUT1 | One cut domain family member. (465 aa) |
| | PGAM2 | Phosphoglycerate mutase 2. (253 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa) |
| | CNTN1 | CNTN1 isoform 1. (1028 aa) |
| | NOTCH2 | NOTCH2 isoform 1. (2612 aa) |
| | ENSPTRP00000075867 | annotation not available (618 aa) |
| | JAG2 | Jagged canonical Notch ligand 2. (1130 aa) |
| | GALNT11-2 | Polypeptide N-acetylgalactosaminyltransferase 11. (608 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa) |
| | HES7 | Hes family bHLH transcription factor 7. (259 aa) |
| | ASCL1 | Achaete-scute family bHLH transcription factor 1. (232 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (500 aa) |
| | MAML3 | MAML3 isoform 1. (1134 aa) |
| | HES5-2 | Hes family bHLH transcription factor 5. (165 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa) |
| | ENSPTRP00000082196 | annotation not available (376 aa) |
| | WDR12 | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (433 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (200 aa) |
| | ENSPTRP00000084287 | annotation not available (136 aa) |
| | ENSPTRP00000086422 | annotation not available (590 aa) |
| | TSPEAR | Thrombospondin type laminin G domain and EAR repeats. (669 aa) |
| | HOXD3 | HOXD3 isoform 3. (432 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (558 aa) |
| | ENSPTRP00000087746 | annotation not available (429 aa) |
| | TMEM100 | Transmembrane protein 100. (134 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (328 aa) |
| | NLE1 | Notchless homolog 1. (485 aa) |
| | PERP | P53 apoptosis effector related to PMP22. (193 aa) |
| | NCSTN | NCSTN isoform 1. (721 aa) |
| | MIB1 | Mindbomb E3 ubiquitin protein ligase 1. (1014 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa) |
