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WNT3 WNT3 TP53 TP53 DVL2 DVL2 FOXF1 FOXF1 HSBP1 HSBP1 MMP15 MMP15 TBX6 TBX6 MESP2 MESP2 MESP1 MESP1 LEO1 LEO1 RTF1 RTF1 OTX2 OTX2 BMP4 BMP4 MMP14 MMP14 ITGA7 ITGA7 ITGA5 ITGA5 GDF3 GDF3 MMP8 MMP8 TENM4 TENM4 WNT11 WNT11 APLNR APLNR RIC8A RIC8A FGFR2 FGFR2 WNT8B WNT8B BMPR1A BMPR1A NODAL NODAL DKK1 DKK1 RNF2 RNF2 SYF2 SYF2 EPHA2 EPHA2 ZBTB17 ZBTB17 INHBA INHBA EYA2 EYA2 LOC459608 LOC459608 ITGB2 ITGB2 PAX2 PAX2 SMAD3 SMAD3 CDC73 CDC73 FRS2 FRS2 FOXA2 FOXA2 GPI GPI COL11A1 COL11A1 MMP2 MMP2 DLD DLD WNT5A WNT5A ITGA8 ITGA8 CK820_G0045089 CK820_G0045089 HNF1A HNF1A NR4A3 NR4A3 ENSPTRP00000083658 ENSPTRP00000083658 ITGA2 ITGA2 ITGB4 ITGB4 RACK1 RACK1 PAF1 PAF1 ENSPTRP00000081143 ENSPTRP00000081143 BMP4-2 BMP4-2 LOC100610514 LOC100610514 LEF1 LEF1 KIF16B KIF16B ACCS ACCS ENSPTRP00000079023 ENSPTRP00000079023 PLPP3 PLPP3 WNT3-2 WNT3-2 SUPT20HL2 SUPT20HL2 ENSPTRP00000077262 ENSPTRP00000077262 ACVR2B ACVR2B DUSP2 DUSP2 ACVR1 ACVR1 ENSPTRP00000075757 ENSPTRP00000075757 FGF8 FGF8 TGFBR2 TGFBR2 KDM6A KDM6A ENSPTRP00000074403 ENSPTRP00000074403 DVL1 DVL1 SCX SCX SOX7 SOX7 DUSP5 DUSP5 NF2 NF2 WLS WLS TXNRD1 TXNRD1 SUPT20H SUPT20H MIXL1 MIXL1 ITGB1 ITGB1 LAMB1 LAMB1 ETV2 ETV2 LRP5 LRP5 GPC3 GPC3 ITGB3 ITGB3 ATOH8 ATOH8 ZIC3 ZIC3 SNAI1 SNAI1 ARFRP1-2 ARFRP1-2 FOXC1 FOXC1 TBX19 TBX19 ENSPTRP00000064416 ENSPTRP00000064416 ENSPTRP00000062821 ENSPTRP00000062821 SMAD2 SMAD2 ENSPTRP00000062011 ENSPTRP00000062011 EPB41L5 EPB41L5 APELA APELA KDM6B KDM6B RPS6 RPS6 S1PR2 S1PR2 TAF10 TAF10 COL8A1 COL8A1 COL4A2 COL4A2 LHX1 LHX1 ARMC5 ARMC5 FOXC2 FOXC2 SFRP1 SFRP1 HMGA2 HMGA2 ITGB5 ITGB5 WNT3A WNT3A ITGAV ITGAV BMPR2 BMPR2 SOX2 SOX2 PRKAR1A PRKAR1A CTNNB1 CTNNB1 ETS2 ETS2 AXIN1 AXIN1 FN1 FN1 CRB2 CRB2 CTR9 CTR9 TASOR TASOR LDB1 LDB1 LAMB3 LAMB3 AMOT AMOT KLF4 KLF4 CER1 CER1 EXT1 EXT1 EYA1 EYA1 SOX17 SOX17 DUSP4 DUSP4 EXOC4 EXOC4 TBX20 TBX20 HOXA11 HOXA11 TBXT TBXT COL12A1 COL12A1 LMBRD1 LMBRD1 SRF SRF DUSP1 DUSP1 HAND1 HAND1 SFRP2 SFRP2 SMAD1 SMAD1 UGDH UGDH POGLUT1 POGLUT1 COL7A1 COL7A1 SETD2 SETD2 EOMES EOMES LRP5L LRP5L HIRA HIRA POFUT2 POFUT2 ARFRP1 ARFRP1 BMP7 BMP7 MMP9 MMP9 MKKS MKKS CUL3 CUL3 ITGA4 ITGA4 ACVR2A ACVR2A TLX2 TLX2 SIX2 SIX2 MSGN1 MSGN1 MEGF8 MEGF8 PRKACA PRKACA SMAD4 SMAD4 LAMA3 LAMA3 GATA6 GATA6 TWSG1 TWSG1 GRB2 GRB2 NOG NOG ITGA3 ITGA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FOXF1FOXF1 isoform 1. (433 aa)
HSBP1Heat shock factor binding protein 1. (76 aa)
MMP15Matrix metallopeptidase 15. (669 aa)
TBX6T-box transcription factor 6. (443 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (389 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ITGA7ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
GDF3Growth differentiation factor 3. (364 aa)
MMP8Matrix metallopeptidase 8. (467 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
RIC8AResistance to inhibitors of cholinesterase 8 homolog A. (530 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNODAL isoform 2. (347 aa)
DKK1Dickkopf-like protein 1. (289 aa)
RNF2Ring finger protein 2. (336 aa)
SYF2SYF2 homolog, RNA splicing factor. (243 aa)
EPHA2EPH receptor A2. (976 aa)
ZBTB17Zinc finger and BTB domain containing 17. (807 aa)
INHBAInhibin subunit beta A. (426 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
LOC459608CFC1B isoform 2. (223 aa)
ITGB2Integrin beta. (863 aa)
PAX2PAX2 isoform 1. (417 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
CDC73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
FOXA2FOXA2 isoform 1. (464 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (597 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
DLDDihydrolipoyl dehydrogenase. (538 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
HNF1AHNF1 homeobox A. (662 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ENSPTRP00000083658annotation not available (282 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
ITGB4Integrin beta. (1822 aa)
RACK1Receptor for activated C kinase 1. (321 aa)
PAF1Paf1, RNA polymerase II associated factor, homolog. (533 aa)
ENSPTRP00000081143annotation not available (219 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LOC100610514Transcription factor SPT20 homolog-like 1. (821 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
KIF16BKIF16B isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1392 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
ENSPTRP00000079023annotation not available (237 aa)
PLPP3T0036865 isoform 1. (342 aa)
WNT3-2Wnt family member 3. (290 aa)
SUPT20HL2Putative transcription factor SPT20 homolog-like 2. (786 aa)
ENSPTRP00000077262annotation not available (314 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ENSPTRP00000075757annotation not available (495 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
KDM6AKDM6A isoform 1. (1453 aa)
ENSPTRP00000074403annotation not available (115 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SOX7SRY-box transcription factor 7. (388 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
WLSWnt ligand secretion mediator. (543 aa)
TXNRD1TXNRD1 isoform 3. (648 aa)
SUPT20HSPT20 homolog, SAGA complex component. (811 aa)
MIXL1Mix paired-like homeobox. (232 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
ETV2ETV2 isoform 5. (370 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
ZIC3Zic family member 3. (466 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ARFRP1-2ADP ribosylation factor related protein 1. (201 aa)
FOXC1FOXC1 isoform 1. (550 aa)
TBX19T-box transcription factor 19. (448 aa)
ENSPTRP00000064416annotation not available (502 aa)
ENSPTRP00000062821annotation not available (220 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSPTRP00000062011annotation not available (389 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
KDM6BLysine demethylase 6B. (1679 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
COL8A1Collagen type VIII alpha 1 chain. (744 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
ARMC5Armadillo repeat containing 5. (1030 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SOX2SRY-box transcription factor 2. (319 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
AXIN1AXIN1 isoform 2. (859 aa)
FN1FN1 isoform 1. (2477 aa)
CRB2CRB2 isoform 1. (1285 aa)
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog. (1173 aa)
TASORTranscription activation suppressor. (1609 aa)
LDB1LIM domain binding 1. (411 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
AMOTAMOT isoform 2. (1094 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
CER1CER1 isoform 1. (267 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SOX17SOX17 isoform 1. (416 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
EXOC4Exocyst complex component 4. (974 aa)
TBX20T-box transcription factor 20. (447 aa)
HOXA11HOXA11 isoform 2. (313 aa)
TBXTT-box transcription factor T. (435 aa)
COL12A1Collagen type XII alpha 1 chain. (3063 aa)
LMBRD1LMBR1 domain containing 1. (540 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
COL7A1Collagen type VII alpha 1 chain. (2944 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
EOMESEOMES isoform 2. (704 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
HIRAProtein HIRA isoform X2. (1017 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. O-fucosylation of TSRs is also requir [...] (413 aa)
ARFRP1ADP-ribosylation factor-related protein 1. (201 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
CUL3CUL3 isoform 2; Belongs to the cullin family. (768 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TLX2T-cell leukemia homeobox 2. (284 aa)
SIX2SIX homeobox 2. (291 aa)
MSGN1MSGN1 isoform 1. (193 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
GATA6GATA binding protein 6. (594 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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