STRINGSTRING
KIFAP3 KIFAP3 TP53 TP53 NF1 NF1 TGFB1 TGFB1 VAX1 VAX1 PTN PTN PAX6 PAX6 PROX1 PROX1 CTNNA1 CTNNA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIFAP3Kinesin-associated protein 3. (792 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NF1Neurofibromin 1. (2839 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
PTNPTN isoform 2. (172 aa)
PAX6PAX6 isoform 13. (436 aa)
PROX1Prospero homeobox 1. (737 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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