28 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAG1	Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
	LAMA5	Laminin, alpha 5. (2203 aa)
	PLXNA1	PLXNA1 isoform 1. (1915 aa)
	LAMA1	Laminin subunit alpha 1. (3104 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SELENOH	Selenoprotein H. (121 aa)
	NKX3-1	NKX3-1 isoform 1. (234 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	SEMA3C	SEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
	PLXND1	PLXND1 isoform 1. (1925 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	TGM2	Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)
	EDAR	Ectodysplasin A receptor. (496 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (717 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	EGFR	ENSPTRP00000023489	ENSPTRP00000069741	Bone morphogenetic protein 7.	Receptor protein-tyrosine kinase.	0.408
BMP7	FGF10	ENSPTRP00000023489	ENSPTRP00000083399	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.505
BMP7	FGF7	ENSPTRP00000023489	ENSPTRP00000012061	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.479
BMP7	FGF8	ENSPTRP00000023489	ENSPTRP00000075677	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.470
BMP7	FGFR2	ENSPTRP00000023489	ENSPTRP00000005308	Bone morphogenetic protein 7.	Fibroblast growth factor receptor.	0.499
BMP7	SHH	ENSPTRP00000023489	ENSPTRP00000075730	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.648
BMP7	TGFB1	ENSPTRP00000023489	ENSPTRP00000018930	Bone morphogenetic protein 7.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.507
BMP7	TWSG1	ENSPTRP00000023489	ENSPTRP00000016778	Bone morphogenetic protein 7.	Twisted gastrulation BMP signaling modulator 1.	0.529
DAG1	EGFR	ENSPTRP00000025763	ENSPTRP00000069741	Dystroglycan 1 (Dystrophin-associated glycoprotein 1).	Receptor protein-tyrosine kinase.	0.423
DAG1	LAMA1	ENSPTRP00000025763	ENSPTRP00000085556	Dystroglycan 1 (Dystrophin-associated glycoprotein 1).	Laminin subunit alpha 1.	0.937
DAG1	LAMA5	ENSPTRP00000025763	ENSPTRP00000089454	Dystroglycan 1 (Dystrophin-associated glycoprotein 1).	Laminin, alpha 5.	0.846
EDA	EDAR	ENSPTRP00000037786	ENSPTRP00000021127	Ectodysplasin A; Belongs to the tumor necrosis factor family.	Ectodysplasin A receptor.	0.974
EDAR	EDA	ENSPTRP00000021127	ENSPTRP00000037786	Ectodysplasin A receptor.	Ectodysplasin A; Belongs to the tumor necrosis factor family.	0.974
EDAR	SHH	ENSPTRP00000021127	ENSPTRP00000075730	Ectodysplasin A receptor.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.502
EDAR	TNF	ENSPTRP00000021127	ENSPTRP00000069905	Ectodysplasin A receptor.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.556
EGFR	BMP7	ENSPTRP00000069741	ENSPTRP00000023489	Receptor protein-tyrosine kinase.	Bone morphogenetic protein 7.	0.408
EGFR	DAG1	ENSPTRP00000069741	ENSPTRP00000025763	Receptor protein-tyrosine kinase.	Dystroglycan 1 (Dystrophin-associated glycoprotein 1).	0.423
EGFR	FGF10	ENSPTRP00000069741	ENSPTRP00000083399	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.855
EGFR	FGF7	ENSPTRP00000069741	ENSPTRP00000012061	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.853
EGFR	FGF8	ENSPTRP00000069741	ENSPTRP00000075677	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.849