84 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LAMB3	Laminin subunit beta 3. (1171 aa)
	HOXC11	HOXC11 isoform 1. (304 aa)
	ITGA5	ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
	ITGA7	ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	PAX9	Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (347 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
	LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
	MMP15	Matrix metallopeptidase 15. (669 aa)
	HSBP1	Heat shock factor binding protein 1. (76 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	BPTF	BPTF isoform 2. (3043 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	GATA6	GATA binding protein 6. (594 aa)
	LAMA3	Laminin subunit alpha 3. (3333 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ITGA4	Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
	MMP9	Matrix metallopeptidase 9. (699 aa)
	EOMES	EOMES isoform 2. (704 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	COL7A1	Collagen type VII alpha 1 chain. (2944 aa)
	PELO	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3063 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	LDB1	LIM domain binding 1. (411 aa)
	CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog. (1173 aa)
	FN1	FN1 isoform 1. (2477 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	ITGAV	Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (799 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (396 aa)
	LHX1	LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1711 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (744 aa)
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (733 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	LOC748850	HDAC2 isoform 9. (445 aa)
	LAMB1	LAMB1 isoform 5. (1789 aa)
	MIXL1	Mix paired-like homeobox. (232 aa)
	DUSP5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	NKX2-1	NKX2-1 isoform 1. (401 aa)
	SOX7	SRY-box transcription factor 7. (388 aa)
	ONECUT1	One cut domain family member. (465 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	LOC737148	Single-stranded DNA-binding protein 3 pseudogene. (331 aa)
	DUSP2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa)
	GATA4	GATA binding protein 4. (443 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	KIF16B	KIF16B isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1392 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	PAF1	Paf1, RNA polymerase II associated factor, homolog. (533 aa)
	CK820_G0045089	RANBP3 isoform 23. (97 aa)
	ENSPTRP00000085013	annotation not available (166 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
	ENSPTRP00000086171	annotation not available (421 aa)
	ENSPTRP00000087502	annotation not available (347 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	COL11A1	Collagen type XI alpha 1 chain. (1818 aa)
	CDC73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)
	ITGB2	Integrin beta. (863 aa)
	BPTF-2	BPTF isoform 1. (2776 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	SSBP3	Single stranded DNA binding protein 3. (388 aa)
	LAMC1	Laminin subunit gamma 1. (1609 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	NODAL	NODAL isoform 2. (347 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	GDF3	Growth differentiation factor 3. (364 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSPTRP00000010780	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	CTNNB1	ENSPTRP00000010780	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4	DKK1	ENSPTRP00000010780	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4	ENSPTRP00000064416	ENSPTRP00000010780	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	GATA4	ENSPTRP00000010780	ENSPTRP00000075865	Bone morphogenetic protein 4.	GATA binding protein 4.	0.781
BMP4	GATA6	ENSPTRP00000010780	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4	NOG	ENSPTRP00000010780	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	PAX9	ENSPTRP00000010780	ENSPTRP00000010655	Bone morphogenetic protein 4.	Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.	0.576
BMP4	SMAD2	ENSPTRP00000010780	ENSPTRP00000062376	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.730
BMP4	SMAD3	ENSPTRP00000010780	ENSPTRP00000090625	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.611
BMP4	SMAD4	ENSPTRP00000010780	ENSPTRP00000017047	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.853
BMP4	SOX17	ENSPTRP00000010780	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4	SOX2	ENSPTRP00000010780	ENSPTRP00000046752	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.566
BMP4-2	BMPR1A	ENSPTRP00000080656	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.892
BMP4-2	CTNNB1	ENSPTRP00000080656	ENSPTRP00000044466	Bone morphogenetic protein 4.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.551
BMP4-2	DKK1	ENSPTRP00000080656	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4-2	ENSPTRP00000064416	ENSPTRP00000080656	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	GATA4	ENSPTRP00000080656	ENSPTRP00000075865	Bone morphogenetic protein 4.	GATA binding protein 4.	0.781