STRINGSTRING
DLL1 DLL1 SKI SKI DMRTA2 DMRTA2 BCL9 BCL9 CASQ1 CASQ1 BTG2 BTG2 HLX HLX ACTA1 ACTA1 ZBTB18 ZBTB18 SVIL SVIL EGR2 EGR2 MYOZ1 MYOZ1 ANKRD1 ANKRD1 MYOD1 MYOD1 CSRP3 CSRP3 BCL9L BCL9L BARX2 BARX2 WNT10B WNT10B ANKRD33 ANKRD33 ITGA7 ITGA7 STAC3 STAC3 MYF6 MYF6 MYF5 MYF5 RB1 RB1 METTL21C METTL21C CFL2 CFL2 ASB2 ASB2 COPS2 COPS2 SOX8 SOX8 NUPR1 NUPR1 MYLPF MYLPF ZNF689 ZNF689 NF1 NF1 HLF HLF VRK3 VRK3 FOXN2 FOXN2 VAMP5 VAMP5 SMYD1 SMYD1 CHRNA1 CHRNA1 HOXD10 HOXD10 CHRND CHRND GPCPD1 GPCPD1 MYLK2 MYLK2 EP300 EP300 EOMES EOMES RHOA RHOA LMOD3 LMOD3 MYH15 MYH15 PHOX2B PHOX2B MYOZ2 MYOZ2 SAP30 SAP30 ANKRD33B ANKRD33B MEGF10 MEGF10 PITX1 PITX1 LEMD2 LEMD2 MAPK14 MAPK14 MED20 MED20 COL19A1 COL19A1 BVES BVES POPDC3 POPDC3 HIVEP3 HIVEP3 R3HDM2 R3HDM2 LOC468314 LOC468314 RYR1 RYR1 ENSPTRP00000092498 ENSPTRP00000092498 KLHL41 KLHL41 SOX11 SOX11 CK820_G0030361 CK820_G0030361 MEF2C MEF2C BCL2 BCL2 MYL6 MYL6 HEYL HEYL FLNB FLNB VAX1 VAX1 RCAN1 RCAN1 SELENON SELENON SPG11 SPG11 ENSPTRP00000085831 ENSPTRP00000085831 EGR1 EGR1 GTF3C5 GTF3C5 DMD-2 DMD-2 KRAS KRAS HOMER1 HOMER1 P2RX2 P2RX2 EMD EMD RXRG RXRG CITED2 CITED2 ELN ELN CDK5 CDK5 HOXD9 HOXD9 NR2F2 NR2F2 CFLAR CFLAR FOS FOS RTL1 RTL1 SHH SHH CACNA1S CACNA1S ENSPTRP00000074929 ENSPTRP00000074929 MEF2D MEF2D R3HDM1 R3HDM1 SCX SCX SRPK3 SRPK3 VGLL2 VGLL2 MTM1 MTM1 SKIL SKIL SIX1 SIX1 ENSPTRP00000069878 ENSPTRP00000069878 DMD DMD CDON CDON RIPOR2 RIPOR2 PPP3CA PPP3CA POPDC2 POPDC2 SMO-2 SMO-2 KEL KEL MYH14 MYH14 PPP3CB PPP3CB ENSPTRP00000064617 ENSPTRP00000064617 NPHS1 NPHS1 KLF5 KLF5 CAV2 CAV2 RTL5 RTL5 BIN3 BIN3 MYOM1 MYOM1 P2RX5 P2RX5 CNTNAP1 CNTNAP1 IGSF8 IGSF8 ATF3 ATF3 WNT3A WNT3A MAFF MAFF PAX5 PAX5 HMG20B HMG20B DNER DNER PEG10 PEG10 KLHL40 KLHL40 MYOG MYOG SIX4 SIX4 CK820_G0014110 CK820_G0014110 CCNT2 CCNT2 MSC MSC NR4A1 NR4A1 TAZ TAZ NOTCH1 NOTCH1 MYORG MYORG PLEC PLEC SMO SMO CAV1 CAV1 MEOX2 MEOX2 TCF21 TCF21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
DMRTA2DMRT like family A2. (539 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
HLXH2.0-like homeobox. (493 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ZBTB18Zinc finger and BTB domain containing 18. (531 aa)
SVILSVIL isoform 6. (2214 aa)
EGR2Early growth response 2. (476 aa)
MYOZ1MYOZ1 isoform 1. (299 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
BCL9LB-cell CLL/lymphoma 9-like. (1499 aa)
BARX2BARX homeobox 2. (279 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ANKRD33Ankyrin repeat domain 33. (452 aa)
ITGA7ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
MYF6Myogenic factor 6. (242 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
RB1RB transcriptional corepressor 1. (928 aa)
METTL21CMETTL21C isoform 1. (284 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
COPS2COP9 constitutive photomorphogenic homolog subunit 2. (450 aa)
SOX8SOX8 isoform 1. (446 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
ZNF689Zinc finger protein 689. (500 aa)
NF1Neurofibromin 1. (2839 aa)
HLFHLF transcription factor, PAR bZIP family member. (295 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
FOXN2FOXN2 isoform 2. (431 aa)
VAMP5Vesicle-associated membrane protein 5 (Myobrevin). (116 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
CHRNA1Cholinergic receptor, nicotinic, alpha 1 (Muscle). (482 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (517 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GDE1 homolog. (672 aa)
MYLK2MYLK2 isoform 1. (596 aa)
EP300E1A binding protein p300. (2175 aa)
EOMESEOMES isoform 2. (704 aa)
RHOARas homolog family member A. (193 aa)
LMOD3LMOD3 isoform 1. (560 aa)
MYH15MYH15 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1946 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
MYOZ2MYOZ2 isoform 1. (264 aa)
SAP30Sin3A-associated protein, 30kDa. (220 aa)
ANKRD33BANKRD33B isoform 1. (494 aa)
MEGF10MEGF10 isoform 2. (1140 aa)
PITX1Homeobox protein. (314 aa)
LEMD2LEM domain containing 2. (503 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
MED20Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa)
COL19A1COL19A1 isoform 1. (1142 aa)
BVESBlood vessel epicardial substance. (360 aa)
POPDC3Popeye domain containing 3. (291 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2405 aa)
R3HDM2R3HDM2 isoform 5. (1035 aa)
LOC468314MYL6 isoform 18. (116 aa)
RYR1RYR1 isoform 3. (5037 aa)
ENSPTRP00000092498Supervillin-like. (133 aa)
KLHL41Kelch repeat and BTB domain-containing protein 5/10. (606 aa)
SOX11Transcription factor SOX. (441 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MYL6MYL6 isoform 8. (233 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
FLNBFilamin B, beta. (2633 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
RCAN1RCAN1 isoform 6. (276 aa)
SELENONT0161445 isoform 2. (581 aa)
SPG11SPG11 isoform 4. (2443 aa)
ENSPTRP00000085831annotation not available (79 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
GTF3C5General transcription factor IIIC, polypeptide 5, 63kDa. (528 aa)
DMD-2Dystrophin. (643 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
HOMER1HOMER1 isoform 1. (344 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (497 aa)
EMDEMD isoform 1. (254 aa)
RXRGRetinoid X receptor gamma. (473 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ELNELN isoform 3. (790 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
HOXD9HOXD9 isoform 1. (356 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RTL1RTL1 isoform 1. (1359 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
ENSPTRP00000074929annotation not available (367 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
R3HDM1R3H domain containing 1. (1102 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SRPK3SRSF protein kinase 3. (634 aa)
VGLL2Vestigial like family member 2. (321 aa)
MTM1MTM1 isoform 1. (745 aa)
SKILSKI like proto-oncogene. (684 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000069878annotation not available (125 aa)
DMDDMD isoform 3. (3685 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1068 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
POPDC2Popeye domain containing 2. (368 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
KELKell metallo-endopeptidase. (732 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
ENSPTRP00000064617annotation not available (92 aa)
NPHS1NPHS1 isoform 1. (1241 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
RTL5Retrotransposon Gag like 5. (569 aa)
BIN3Bridging integrator 3. (253 aa)
MYOM1MYOM1 isoform 1. (1647 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (431 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
IGSF8Immunoglobulin superfamily member 8. (613 aa)
ATF3Activating transcription factor 3. (181 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAFFV-maf musculoaponeurotic fibrosarcoma oncogene homolog F (Avian). (164 aa)
PAX5PAX5 isoform 1. (391 aa)
HMG20BHigh mobility group 20B. (317 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
PEG10PEG10 isoform 4. (775 aa)
KLHL40Kelch like family member 40. (621 aa)
MYOGMYOG isoform 1. (249 aa)
SIX4SIX homeobox 4. (781 aa)
CK820_G0014110KEL isoform 1. (732 aa)
CCNT2CCNT2 isoform 4; Belongs to the cyclin family. (730 aa)
MSCMSC isoform 1. (295 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
TAZTafazzin; Some isoforms may be involved in cardiolipin metabolism; Belongs to the taffazin family. (286 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
MYORGMyogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (714 aa)
PLECPLEC isoform 2. (4684 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
TCF21Transcription factor 21. (179 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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