STRINGSTRING
APP APP OPRD1 OPRD1 POU4F1 POU4F1 NEGR1 NEGR1 UBE2Q1 UBE2Q1 PRLHR PRLHR TH TH GAL GAL GPR83 GPR83 BSX BSX DERL2 DERL2 PMCH PMCH MMP17 MMP17 DACH1 DACH1 CK820_G0025122 CK820_G0025122 NPW NPW AGRP AGRP HCRT HCRT PPY PPY GALR2 GALR2 MC4R MC4R GDF15 GDF15 UCN UCN PEX13 PEX13 TACR1 TACR1 GLS GLS OXT OXT ADORA2A ADORA2A GALR3 GALR3 OXTR OXTR CCK CCK TRH TRH P2RY1 P2RY1 GHSR GHSR BBS12 BBS12 NPY1R NPY1R NPY5R NPY5R NMUR2 NMUR2 HCRTR2 HCRTR2 GFRAL GFRAL MRAP2 MRAP2 CNTFR CNTFR RMI1 RMI1 ACE2 ACE2 HTR2C HTR2C BRS3 BRS3 PYY PYY TBR1 TBR1 ATP8A2 ATP8A2 DMBX1 DMBX1 NPSR1 NPSR1 CARTPT CARTPT GCG GCG EN1 EN1 HAND2 HAND2 REN REN CALCA CALCA ADM2 ADM2 DRD1 DRD1 ENSPTRP00000067301 ENSPTRP00000067301 DRD2 DRD2 PRLH PRLH CPT1A CPT1A LEP LEP BBIP1 BBIP1 HELT HELT UBR3 UBR3 NTRK2 NTRK2 FYN FYN IAPP IAPP GHRL GHRL FOS FOS STRA6 STRA6 NPB NPB HCRTR1 HCRTR1 CNTN2 CNTN2 ENSPTRP00000086760 ENSPTRP00000086760 ENSPTRP00000087048 ENSPTRP00000087048 USP46 USP46 STAT3 STAT3 UCHL1 UCHL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
POU4F1POU domain protein. (350 aa)
NEGR1NEGR1 isoform 1. (354 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
THTyrosine hydroxylase. (528 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (422 aa)
BSXBrain specific homeobox. (233 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
PMCHPro-MCH. (165 aa)
MMP17Matrix metallopeptidase 17 (Membrane-inserted). (604 aa)
DACH1DACH1 isoform 4. (761 aa)
CK820_G0025122SLC24A4 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (343 aa)
NPWNPW isoform 2. (230 aa)
AGRPAgouti related neuropeptide. (132 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
PPYPancreatic polypeptide. (95 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
MC4RMelanocortin 4 receptor. (332 aa)
GDF15Growth differentiation factor 15. (308 aa)
UCNUCN isoform 1. (124 aa)
PEX13Peroxisomal biogenesis factor 13. (403 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GLSGLS isoform 1. (669 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
GALR3Galanin receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
CCKCCK isoform 2. (115 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
BBS12BBS12 isoform 1. (710 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
NMUR2Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
GFRALGDNF family receptor alpha like. (394 aa)
MRAP2Melanocortin 2 receptor accessory protein 2. (205 aa)
CNTFRCNTFR isoform 1. (372 aa)
RMI1RMI1, RecQ mediated genome instability 1, homolog. (625 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
HTR2C5-hydroxytryptamine receptor 2C; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathway [...] (458 aa)
BRS3Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
PYYPYY isoform 1. (95 aa)
TBR1T-box brain transcription factor 1. (682 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1188 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (377 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
CARTPTCART prepropeptide. (116 aa)
GCGGCG isoform 1. (180 aa)
EN1Homeobox protein engrailed-like. (396 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ADM2ADM2 isoform 1. (127 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ENSPTRP00000067301annotation not available (92 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
PRLHProlactin releasing hormone. (87 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
BBIP1BBSome interacting protein 1. (102 aa)
HELTHELT isoform 3. (327 aa)
UBR3E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1888 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FYNTyrosine-protein kinase. (537 aa)
IAPPIslet amyloid polypeptide. (89 aa)
GHRLGHRL isoform 10. (117 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
NPBNeuropeptide B. (125 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
ENSPTRP00000086760annotation not available (458 aa)
ENSPTRP00000087048annotation not available (82 aa)
USP46Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (368 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (260 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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