STRINGSTRING
CHD7 CHD7 PARK7 PARK7 PAFAH1B1 PAFAH1B1 ENSPTRP00000077189 ENSPTRP00000077189 SPTBN4 SPTBN4 CLN8 CLN8 PREX2 PREX2 OXR1 OXR1 HTRA2 HTRA2 ENSPTRP00000072952 ENSPTRP00000072952 GLRB GLRB PUM1 PUM1 ENSPTRP00000070902 ENSPTRP00000070902 ENSPTRP00000070863 ENSPTRP00000070863 ENSPTRP00000070307 ENSPTRP00000070307 ABHD12 ABHD12 DRD2 DRD2 ZIC1 ZIC1 AGTPBP1 AGTPBP1 CXCL12 CXCL12 PBX3 PBX3 DRD1 DRD1 KLHL5 KLHL5 GRIN2D GRIN2D TSC1 TSC1 CK820_G0054728 CK820_G0054728 TBCE TBCE SLITRK6 SLITRK6 CACNB4 CACNB4 ADAM22 ADAM22 OTOG OTOG NLGN2 NLGN2 DAB1 DAB1 BTBD9 BTBD9 EN1 EN1 CEND1 CEND1 DMBX1 DMBX1 INPP5F INPP5F TMOD1 TMOD1 KLHL4 KLHL4 NPC1 NPC1 DMRT3 DMRT3 ARCN1 ARCN1 GBX1 GBX1 HIPK2 HIPK2 PRKN PRKN GLRA1 GLRA1 TRH TRH CHL1 CHL1 CK820_G0037244 CK820_G0037244 HOXD10 HOXD10 SCN1A SCN1A NTF4 NTF4 LGI4 LGI4 GIP GIP CNP CNP SEZ6 SEZ6 ARRB2 ARRB2 CTNS CTNS NTAN1 NTAN1 EPS8 EPS8 CCND2 CCND2 SHANK2 SHANK2 DRD4 DRD4 OPRD1 OPRD1 SEZ6L2 SEZ6L2 ENSPTRP00000081136 ENSPTRP00000081136 MECP2 MECP2 ATP1A2 ATP1A2 FXN FXN KALRN KALRN CNTN2 CNTN2 EPHA4 EPHA4 SNCG SNCG CSTB CSTB CLCN3 CLCN3 EFNB3 EFNB3 NTAN1-2 NTAN1-2 KLHL1 KLHL1 NR4A2 NR4A2 HOXB8 HOXB8 CELF6-2 CELF6-2 FGF12 FGF12 FOXA2 FOXA2 ADAM22-2 ADAM22-2 SNCA SNCA TSHR TSHR PPT1 PPT1 UCHL1 UCHL1 APP APP ZMPSTE24 ZMPSTE24 HOXD9 HOXD9 OXR1-2 OXR1-2 PCDH15 PCDH15
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD7CHD7 isoform 1. (2997 aa)
PARK7PARK7 isoform 1. (189 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
ENSPTRP00000077189annotation not available (276 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1620 aa)
OXR1OXR1 isoform 3. (872 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ENSPTRP00000072952annotation not available (212 aa)
GLRBGlycine receptor, beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
PUM1PUM1 isoform 1. (1216 aa)
ENSPTRP00000070902annotation not available (168 aa)
ENSPTRP00000070863annotation not available (261 aa)
ENSPTRP00000070307annotation not available (237 aa)
ABHD12Abhydrolase domain containing 12. (404 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
ZIC1Zic family member 1. (447 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PBX3PBX homeobox 3. (455 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
KLHL5Kelch like family member 5. (757 aa)
GRIN2DGRIN2D isoform 1. (1265 aa)
TSC1TSC complex subunit 1. (1164 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
TBCETBCE isoform 2. (566 aa)
SLITRK6SLITRK6 isoform 1. (841 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
ADAM22ADAM metallopeptidase domain 22. (906 aa)
OTOGOTOG isoform 2. (2925 aa)
NLGN2NLGN2 isoform 1. (836 aa)
DAB1DAB adaptor protein 1. (588 aa)
BTBD9BTB (POZ) domain containing 9. (612 aa)
EN1Homeobox protein engrailed-like. (396 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (377 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1133 aa)
TMOD1TMOD1 isoform 1. (359 aa)
KLHL4Kelch like family member 4. (718 aa)
NPC1Niemann-Pick disease, type C1. (1280 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (552 aa)
GBX1Gastrulation brain homeobox 1. (363 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
GLRA1GLRA1 isoform 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
CHL1Cell adhesion molecule with homology to L1CAM (Close homolog of L1). (1225 aa)
CK820_G0037244NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
GIPGastric inhibitory polypeptide. (153 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
SEZ6Seizure related 6 homolog. (994 aa)
ARRB2ARRB2 isoform 2. (430 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
NTAN1N-terminal asparagine amidase. (310 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (822 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1849 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
SEZ6L2Seizure related 6 homolog-like 2. (923 aa)
ENSPTRP00000081136LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
FXNFXN isoform 1. (210 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
EPHA4EPH receptor A4. (986 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (170 aa)
CSTBCystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B (By similarity). (98 aa)
CLCN3Chloride channel protein. (866 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
NTAN1-2N-terminal asparagine amidase. (310 aa)
KLHL1Kelch like family member 1. (748 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
HOXB8HOXB8 isoform 1. (243 aa)
CELF6-2CUGBP Elav-like family member 6 isoform X1. (538 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FOXA2FOXA2 isoform 1. (464 aa)
ADAM22-2ADAM22 isoform 3. (923 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
PPT1Palmitoyl-protein thioesterase 1. (335 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (260 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
HOXD9HOXD9 isoform 1. (356 aa)
OXR1-2Oxidation resistance 1. (198 aa)
PCDH15Protocadherin related 15. (1954 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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