STRINGSTRING
SF1 SF1 TFPT-2 TFPT-2 ENSPTRP00000089693 ENSPTRP00000089693 BCL2 BCL2 REC8 REC8 INHBB INHBB LOC450610 LOC450610 PRDX4 PRDX4 BAX BAX CK820_G0006425 CK820_G0006425 INHBA INHBA RNF38 RNF38 WDR48 WDR48 UTF1 UTF1 INSR INSR WNT4 WNT4 HSD17B4 HSD17B4 ENSPTRP00000063979 ENSPTRP00000063979 ENSPTRP00000064362 ENSPTRP00000064362 KIF18A KIF18A SDC1 SDC1 MSH2 MSH2 HOXA10 HOXA10 ENSPTRP00000067006 ENSPTRP00000067006 HOXA10-2 HOXA10-2 NASP-2 NASP-2 CSMD1 CSMD1 SGPL1 SGPL1 ARID4A ARID4A CSDE1 CSDE1 NKX2-1 NKX2-1 GATA3 GATA3 TGFBR1 TGFBR1 SCX SCX ENSPTRP00000074950 ENSPTRP00000074950 DHH DHH SCAPER SCAPER GATA4 GATA4 TLR5 TLR5 BCL2L11 BCL2L11 ERCC1 ERCC1 AR AR ENSPTRP00000077262 ENSPTRP00000077262 LOC107971060 LOC107971060 ADAM21 ADAM21 AKR1C3 AKR1C3 LHX9 LHX9 PDGFRB PDGFRB ENSPTRP00000080456 ENSPTRP00000080456 TEX19 TEX19 NKX3-1 NKX3-1 CITED2 CITED2 MAMLD1-2 MAMLD1-2 PLEKHA1 PLEKHA1 LOC467495 LOC467495 NTRK1 NTRK1 NHLH2 NHLH2 FNDC3A FNDC3A TMF1 TMF1 SRD5A2 SRD5A2 CCND1 CCND1 NASP NASP RAB13 RAB13 TGFB2 TGFB2 ARID4B ARID4B FSHB FSHB CBL CBL YBX3 YBX3 AMHR2 AMHR2 KITLG KITLG TESC TESC FGF9 FGF9 RXFP2 RXFP2 MMP14 MMP14 LOC467493 LOC467493 SOX8 SOX8 NUPR1 NUPR1 FANCA FANCA SOX15 SOX15 KLHL10 KLHL10 BRIP1 BRIP1 SOX9 SOX9 GATA6 GATA6 SMAD4 SMAD4 AMH AMH TFPT TFPT CYP1B1 CYP1B1 LHCGR LHCGR FSHR FSHR ACVR2A ACVR2A LRP2 LRP2 INHA INHA BCL2L1 BCL2L1 EIF2S2 EIF2S2 TFAP2C TFAP2C COL9A3 COL9A3 PATZ1 PATZ1 BIK BIK KIT KIT SFRP2 SFRP2 ADAM29 ADAM29 ING2 ING2 TLR3 TLR3 SRD5A1 SRD5A1 RHOBTB3 RHOBTB3 FER FER CTNNA1 CTNNA1 NCOA4 NCOA4 MEA1 MEA1 TCF21 TCF21 ESR1 ESR1 MAS1 MAS1 NUDT1 NUDT1 MAMLD1 MAMLD1 HOXA11 HOXA11 LRRC6 LRRC6 DMRT1 DMRT1 PRKACG PRKACG NR5A1 NR5A1 ACE ACE NUP210L NUP210L ADAM15 ADAM15 TNFSF10 TNFSF10 SIX4 SIX4 AGO4 AGO4 CRKL CRKL TEX11 TEX11 NR0B1 NR0B1 REN REN ASPM ASPM TBC1D20 TBC1D20 CSMD2 CSMD2 ADAM20 ADAM20 RARA RARA SFRP1 SFRP1 ZFP42 ZFP42 WNT2B WNT2B ADGRG1 ADGRG1 KDM5A KDM5A LOC100614689 LOC100614689 ATN1 ATN1 WNT5A WNT5A GATA1 GATA1 SAFB2 SAFB2 ATRX ATRX WT1 WT1 ARID5B ARID5B GFRA1 GFRA1 LOC467971 LOC467971 ENSPTRP00000089450 ENSPTRP00000089450
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SF1Splicing factor 1. (675 aa)
TFPT-2TCF3 fusion partner. (253 aa)
ENSPTRP00000089693annotation not available (226 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
REC8Meiotic recombination protein REC8-like 1. (547 aa)
INHBBInhibin subunit beta B. (407 aa)
LOC450610Eukaryotic translation initiation factor 2 subunit 2 pseudogene. (284 aa)
PRDX4PRDX4 isoform 2. (271 aa)
BAXBAX isoform 7. (123 aa)
CK820_G0006425TFAP2C isoform 2. (436 aa)
INHBAInhibin subunit beta A. (426 aa)
RNF38Ring finger protein 38. (517 aa)
WDR48WD repeat domain 48. (684 aa)
UTF1Undifferentiated embryonic cell transcription factor 1. (341 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
HSD17B4Hydroxysteroid (17-beta) dehydrogenase 4. (809 aa)
ENSPTRP00000063979annotation not available (506 aa)
ENSPTRP00000064362annotation not available (543 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (898 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa)
HOXA10HOXA10 isoform 2. (410 aa)
ENSPTRP00000067006Disintegrin and metalloproteinase domain-containing protein 21-like. (718 aa)
HOXA10-2Homeobox A10. (410 aa)
NASP-2Nuclear autoantigenic sperm protein (Histone-binding). (724 aa)
CSMD1CSMD1 isoform 2. (3565 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ARID4AAT-rich interaction domain 4A. (1259 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
GATA3GATA binding protein 3. (444 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
ENSPTRP00000074950annotation not available (707 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1403 aa)
GATA4GATA binding protein 4. (443 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
ENSPTRP00000077262annotation not available (314 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ADAM21ADAM21 isoform 1. (491 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
LHX9LHX9 isoform 2. (397 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSPTRP00000080456annotation not available (1174 aa)
TEX19Testis expressed 19. (164 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
PLEKHA1Pleckstrin homology domain containing, family A (Phosphoinositide binding specific) member 1. (404 aa)
LOC467495Disintegrin and metalloproteinase domain-containing protein 20-like. (738 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
TMF1TATA element modulatory factor 1. (1096 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
NASPNuclear autoantigenic sperm protein (Histone-binding). (788 aa)
RAB13RAB13, member RAS oncogene family. (203 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ARID4BAT rich interactive domain 4B (RBP1-like). (1313 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
YBX3Cold shock domain protein A. (374 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
TESCTESC isoform 2. (214 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RXFP2Relaxin family peptide receptor 2. (754 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
LOC467493LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 21-like. (465 aa)
SOX8SOX8 isoform 1. (446 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
FANCAFANCA isoform 6. (1455 aa)
SOX15SOX15 isoform 1. (233 aa)
KLHL10Kelch like family member 10. (608 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GATA6GATA binding protein 6. (594 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AMHAnti-Mullerian hormone. (560 aa)
TFPTTCF3 (E2A) fusion partner (In childhood Leukemia). (253 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
LRP2LRP2 isoform 1. (4655 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
EIF2S2Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa. (333 aa)
TFAP2CTranscription factor AP-2 gamma. (450 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
PATZ1POZ (BTB) and AT hook containing zinc finger 1. (687 aa)
BIKBCL2 interacting killer. (160 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
ADAM29ADAM29 isoform 12. (926 aa)
ING2Inhibitor of growth protein. (280 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
RHOBTB3Rho-related BTB domain containing 3. (611 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
MEA1Male-enhanced antigen 1. (185 aa)
TCF21Transcription factor 21. (179 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
MAS1MAS1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
NUDT1Nudix (Nucleoside diphosphate linked moiety X)-type motif 1; Belongs to the Nudix hydrolase family. (190 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
HOXA11HOXA11 isoform 2. (313 aa)
LRRC6LRRC6 isoform 1. (466 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
NUP210LNUP210L isoform 1. (1888 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (282 aa)
SIX4SIX homeobox 4. (781 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
TEX11TEX11 isoform 1. (912 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (470 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
TBC1D20TBC1 domain family, member 20. (403 aa)
CSMD2CUB and Sushi multiple domains 2. (3631 aa)
ADAM20ADAM metallopeptidase domain 20. (776 aa)
RARARARA isoform 4. (624 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
ZFP42ZFP42 zinc finger protein. (310 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
KDM5ALysine (K)-specific demethylase 5A. (1690 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
ATN1Atrophin-1; Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Recruits NR2E1 to repress transcription. Has some intrinsic repression activity. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). (1224 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
GATA1GATA binding protein 1. (413 aa)
SAFB2SAFB2 isoform 1. (924 aa)
ATRXTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2492 aa)
WT1WT1 transcription factor. (514 aa)
ARID5BARID5B isoform 1. (1187 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
LOC467971Disintegrin and metalloproteinase domain-containing protein 21-like. (633 aa)
ENSPTRP00000089450annotation not available (303 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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