STRINGSTRING
COPG2 COPG2 MAFA MAFA SYTL4 SYTL4 DMTN DMTN FKBP1B FKBP1B ENSPTRP00000044990 ENSPTRP00000044990 GPR119 GPR119 TACR2 TACR2 ANXA1 ANXA1 PREB PREB PRKCE PRKCE PLEK PLEK STEAP3 STEAP3 ACVR1C ACVR1C RESP18 RESP18 SCG2 SCG2 NECAB3 NECAB3 CBLN4 CBLN4 AP1B1 AP1B1 MON1A MON1A SERP1 SERP1 GOLPH3 GOLPH3 RAB3C RAB3C CANX CANX RAB3B RAB3B STXBP3 STXBP3 RAB13 RAB13 UBE2Q1 UBE2Q1 ILDR2 ILDR2 CCDC186 CCDC186 GAL GAL SNX19 SNX19 M6PR M6PR GNPTAB GNPTAB ERP29 ERP29 PDX1 PDX1 SUCNR1 SUCNR1 RAB15 RAB15 TVP23B TVP23B TANGO6 TANGO6 CK820_G0015936 CK820_G0015936 COMP COMP TSGA13 TSGA13 GNAS GNAS CAVIN1 CAVIN1 MIA2 MIA2 SELENOT SELENOT LOC463809 LOC463809 EDNRB EDNRB HIF1A HIF1A SEL1L SEL1L NAGPA NAGPA TVP23A TVP23A CBLN1 CBLN1 PPY PPY ADCYAP1 ADCYAP1 RAB12 RAB12 MC4R MC4R AP1M2 AP1M2 PARK7 PARK7 SVBP SVBP CAMK2G CAMK2G ENSPTRP00000092222 ENSPTRP00000092222 LOC100613273 LOC100613273 MTTP MTTP AP1G1 AP1G1 LOC470576 LOC470576 ENSPTRP00000090262 ENSPTRP00000090262 RAB10 RAB10 ENSPTRP00000089584 ENSPTRP00000089584 ENSPTRP00000089565 ENSPTRP00000089565 BLOC1S6 BLOC1S6 RAF1 RAF1 CTAGE1 CTAGE1 RAB11FIP5 RAB11FIP5 STX1A-2 STX1A-2 LOC100615924 LOC100615924 ENSPTRP00000086609 ENSPTRP00000086609 SNCG SNCG GPR68 GPR68 PDIA4-2 PDIA4-2 ENSPTRP00000084970 ENSPTRP00000084970 HNF1A HNF1A CLTRN CLTRN PAFAH1B1 PAFAH1B1 RAB3A RAB3A PTPRN2 PTPRN2 PTPRN PTPRN ACVR2B ACVR2B ENSPTRP00000076468 ENSPTRP00000076468 SREBF1 SREBF1 ENSPTRP00000075518 ENSPTRP00000075518 RAB11FIP2 RAB11FIP2 LEP LEP TANGO2 TANGO2 ENSPTRP00000083890 ENSPTRP00000083890 COPG1 COPG1 FGG FGG OLFM2 OLFM2 HNF1B HNF1B FAM3B FAM3B ENSPTRP00000081776 ENSPTRP00000081776 IL1RN IL1RN MIA3 MIA3 ENSPTRP00000079262 ENSPTRP00000079262 WLS WLS ENSPTRP00000070902 ENSPTRP00000070902 NECAB3-2 NECAB3-2 CDRT4 CDRT4 RAB11B RAB11B LTBP2 LTBP2 ARFGAP3 ARFGAP3 TMEM167A TMEM167A TSGA13-2 TSGA13-2 ENSPTRP00000064593 ENSPTRP00000064593 PCLO PCLO ARL4D ARL4D CPLX1 CPLX1 ABCA1 ABCA1 ENSPTRP00000062696 ENSPTRP00000062696 SMAD2 SMAD2 CPLX3 CPLX3 LOC455050 LOC455050 RAPGEF4 RAPGEF4 RAB8B RAB8B PORCN PORCN RAB3D RAB3D RAB8A RAB8A FFAR1 FFAR1 BLOC1S3 BLOC1S3 RCN3 RCN3 CYB5R4 CYB5R4 VIP VIP STX1A STX1A AP1S1 AP1S1 PDIA4 PDIA4 SLC30A8 SLC30A8 PCSK5 PCSK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COPG2Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (871 aa)
MAFAMAF bZIP transcription factor A. (348 aa)
SYTL4Synaptotagmin-like 4. (672 aa)
DMTNDematin actin binding protein. (405 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ENSPTRP00000044990annotation not available (62 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
PREBProlactin regulatory element binding. (417 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PLEKPLEK isoform 1. (350 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
RESP18Regulated endocrine specific protein 18. (228 aa)
SCG2Secretogranin II. (610 aa)
NECAB3NECAB3 isoform 3. (400 aa)
CBLN4Cerebellin 4 precursor. (201 aa)
AP1B1AP complex subunit beta. (947 aa)
MON1AMON1 homolog A, secretory trafficking associated. (652 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
GOLPH3Golgi phosphoprotein 3 (Coat-protein). (298 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
CANXCANX isoform 1. (592 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RAB13RAB13, member RAS oncogene family. (203 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (639 aa)
CCDC186Chromosome 10 open reading frame 118. (898 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
SNX19Sorting nexin 19. (992 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (277 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits. (1256 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
SUCNR1SUCNR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
RAB15RAB15, member RAS onocogene family. (208 aa)
TVP23BTVP23C-CDRT4 isoform 4. (199 aa)
TANGO6Transport and golgi organization 6 homolog. (1095 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
TSGA13Testis specific 13. (275 aa)
GNASGNAS isoform 19. (1042 aa)
CAVIN1Caveolae associated protein 1. (390 aa)
MIA2MIA SH3 domain ER export factor 2. (1412 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
LOC463809cTAGE family member 15-like. (709 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (515 aa)
TVP23AGolgi apparatus membrane protein TVP23 homolog. (213 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
PPYPancreatic polypeptide. (95 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
RAB12RAB12, member RAS oncogene family. (244 aa)
MC4RMelanocortin 4 receptor. (332 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa)
PARK7PARK7 isoform 1. (189 aa)
SVBPCoiled-coil domain containing 23. (66 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase II gamma. (562 aa)
ENSPTRP00000092222annotation not available (291 aa)
LOC100613273LOW QUALITY PROTEIN: endoplasmic reticulum export factor CTAGE5-like. (749 aa)
MTTPMicrosomal triglyceride transfer protein. (921 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
LOC470576CTAGE9 isoform 1. (776 aa)
ENSPTRP00000090262annotation not available (90 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
ENSPTRP00000089584annotation not available (842 aa)
ENSPTRP00000089565annotation not available (801 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (177 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
CTAGE1CTAGE1 isoform 2. (794 aa)
RAB11FIP5RAB11FIP5 isoform 1. (1320 aa)
STX1A-2Syntaxin 1A. (344 aa)
LOC100615924Endoplasmic reticulum export factor CTAGE5 pseudogene. (795 aa)
ENSPTRP00000086609annotation not available (729 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (170 aa)
GPR68GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PDIA4-2Protein disulfide isomerase family A member 4. (645 aa)
ENSPTRP00000084970annotation not available (148 aa)
HNF1AHNF1 homeobox A. (662 aa)
CLTRNTMEM27 isoform 1. (247 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
PTPRN2PTPRN2 isoform 5. (457 aa)
PTPRNProtein tyrosine phosphatase, receptor type, N. (979 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ENSPTRP00000076468annotation not available (140 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
ENSPTRP00000075518annotation not available (695 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
TANGO2Transport and golgi organization 2 homolog. (317 aa)
ENSPTRP00000083890annotation not available (95 aa)
COPG1Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (880 aa)
FGGFibrinogen gamma chain. (453 aa)
OLFM2OLFM2 isoform 1. (478 aa)
HNF1BHNF1 homeobox B. (557 aa)
FAM3BFAM3B isoform 5. (266 aa)
ENSPTRP00000081776annotation not available (342 aa)
IL1RNInterleukin-1. (180 aa)
MIA3MIA3 isoform 1. (1983 aa)
ENSPTRP00000079262annotation not available (866 aa)
WLSWnt ligand secretion mediator. (543 aa)
ENSPTRP00000070902annotation not available (168 aa)
NECAB3-2N-terminal EF-hand calcium binding protein 3. (398 aa)
CDRT4CMT1A duplicated region transcript 4. (192 aa)
RAB11BRAB11B, member RAS oncogene family. (221 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
ARFGAP3ADP-ribosylation factor GTPase-activating protein 3. (516 aa)
TMEM167AProtein kish; Involved in the early part of the secretory pathway. (72 aa)
TSGA13-2Testis specific 13. (270 aa)
ENSPTRP00000064593annotation not available (667 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5203 aa)
ARL4DADP ribosylation factor like GTPase 4D; Belongs to the small GTPase superfamily. Arf family. (201 aa)
CPLX1CPLX1 isoform 1. (134 aa)
ABCA1ATP-binding cassette, sub-family A (ABC1), member 1. (2264 aa)
ENSPTRP00000062696annotation not available (320 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CPLX3CPLX3 isoform 1. (158 aa)
LOC455050Golgi apparatus membrane protein TVP23 homolog. (205 aa)
RAPGEF4RAPGEF4 isoform 2. (1011 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (200 aa)
RCN3Reticulocalbin 3, EF-hand calcium binding domain. (336 aa)
CYB5R4Cytochrome b5 reductase 4. (521 aa)
VIPVasoactive intestinal peptide. (169 aa)
STX1ASTX1A isoform 3; Belongs to the syntaxin family. (288 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
PDIA4Protein disulfide-isomerase A4. (645 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1860 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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