35 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LRP4	Low density lipoprotein receptor-related protein 4. (1906 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	NODAL	NODAL isoform 2. (347 aa)
	HOXC11	HOXC11 isoform 1. (304 aa)
	HOXC10	Homeobox protein Hox-C10. (342 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	IRX3	Iroquois homeobox 3. (500 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	SIX3	SIX homeobox 3. (331 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	HOXD10	Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	IRX2	Iroquois homeobox 2. (471 aa)
	IRX1	Iroquois homeobox 1. (480 aa)
	PBX2	Pre-B-cell leukemia homeobox 2. (430 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	HOXA11	HOXA11 isoform 2. (313 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	HOXB9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
	EN1	Homeobox protein engrailed-like. (396 aa)
	SP8	Sp8 transcription factor. (507 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	ENSPTRP00000077262	annotation not available (314 aa)
	HOXA10-2	Homeobox A10. (410 aa)
	HOXA10	HOXA10 isoform 2. (410 aa)
	PBX1	Pre-B-cell leukemia homeobox 1. (486 aa)
	HOXD9	HOXD9 isoform 1. (356 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	CYP26B1	ENSPTRP00000012165	ENSPTRP00000080569	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.970
ALDH1A2	GLI2	ENSPTRP00000012165	ENSPTRP00000040313	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	GLI family zinc finger 2.	0.512
CTNNB1	DLL1	ENSPTRP00000044466	ENSPTRP00000032142	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.535
CTNNB1	FGF10	ENSPTRP00000044466	ENSPTRP00000083399	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
CTNNB1	GLI1	ENSPTRP00000044466	ENSPTRP00000078209	Catenin (Cadherin-associated protein), beta 1, 88kDa.	GLI family zinc finger 1.	0.664
CTNNB1	GLI2	ENSPTRP00000044466	ENSPTRP00000040313	Catenin (Cadherin-associated protein), beta 1, 88kDa.	GLI family zinc finger 2.	0.509
CTNNB1	GLI3	ENSPTRP00000044466	ENSPTRP00000032656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.520
CTNNB1	LRP4	ENSPTRP00000044466	ENSPTRP00000082021	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Low density lipoprotein receptor-related protein 4.	0.424
CTNNB1	WNT8A	ENSPTRP00000044466	ENSPTRP00000088519	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.688
CYP26B1	ALDH1A2	ENSPTRP00000080569	ENSPTRP00000012165	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	0.970
DLL1	CTNNB1	ENSPTRP00000032142	ENSPTRP00000044466	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.535
DLL1	HES5	ENSPTRP00000032142	ENSPTRP00000040760	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLL1	HES5-2	ENSPTRP00000032142	ENSPTRP00000080637	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLX1	DLX2	ENSPTRP00000039172	ENSPTRP00000021601	Distal-less homeobox 1.	Distal-less homeobox 2.	0.862
DLX1	IRX1	ENSPTRP00000039172	ENSPTRP00000028672	Distal-less homeobox 1.	Iroquois homeobox 1.	0.493
DLX1	IRX2	ENSPTRP00000039172	ENSPTRP00000028671	Distal-less homeobox 1.	Iroquois homeobox 2.	0.511
DLX1	PBX1	ENSPTRP00000039172	ENSPTRP00000061415	Distal-less homeobox 1.	Pre-B-cell leukemia homeobox 1.	0.407
DLX1	PBX2	ENSPTRP00000039172	ENSPTRP00000030759	Distal-less homeobox 1.	Pre-B-cell leukemia homeobox 2.	0.407
DLX2	DLX1	ENSPTRP00000021601	ENSPTRP00000039172	Distal-less homeobox 2.	Distal-less homeobox 1.	0.862
DLX2	HES5	ENSPTRP00000021601	ENSPTRP00000040760	Distal-less homeobox 2.	Hes family bHLH transcription factor 5.	0.443