STRINGSTRING
TFAP2A TFAP2A BCL2 BCL2 SNCA SNCA BECN1-2 BECN1-2 SLC11A2 SLC11A2 HIF1A HIF1A B2M B2M ABAT ABAT HAMP HAMP CYBRD1 CYBRD1 SLC40A1 SLC40A1 MAP1LC3A MAP1LC3A TFF1 TFF1 HMOX1 HMOX1 CPOX CPOX TF TF SLC6A3 SLC6A3 BMP6 BMP6 ATG5 ATG5 TFR2 TFR2 ACO1 ACO1 G6PD G6PD FN1 FN1 BECN1 BECN1 TFRC TFRC CYP1A1 CYP1A1 ATP7A ATP7A ALAD ALAD ENSPTRP00000072952 ENSPTRP00000072952 ENSPTRP00000078404 ENSPTRP00000078404 HFE HFE FXN FXN ENSPTRP00000084510 ENSPTRP00000084510 CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFAP2ATranscription factor AP-2 alpha. (439 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
BECN1-2BECN1 isoform 3. (371 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
CYBRD1Cytochrome b reductase 1. (286 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
TFF1TFF1 isoform 1. (84 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
CPOXCoproporphyrinogen oxidase. (454 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TFR2Transferrin receptor 2. (801 aa)
ACO1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (889 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
FN1FN1 isoform 1. (2477 aa)
BECN1Beclin 1, autophagy related. (450 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
ENSPTRP00000072952annotation not available (212 aa)
ENSPTRP00000078404annotation not available (801 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
FXNFXN isoform 1. (210 aa)
ENSPTRP00000084510annotation not available (456 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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