21 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	LRP2	LRP2 isoform 1. (4655 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	FOXH1	FOXH1 isoform 1. (365 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	FOXH1-2	Forkhead box H1. (365 aa)
	SMARCD3-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PAX8	PAX8 isoform 1. (456 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	PAX2	PAX2 isoform 1. (417 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSPTRP00000016228	ENSPTRP00000010780	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	BMP4-2	ENSPTRP00000016228	ENSPTRP00000080656	AXIN2 isoform 1.	Bone morphogenetic protein 4.	0.455
AXIN2	LRP2	ENSPTRP00000016228	ENSPTRP00000021546	AXIN2 isoform 1.	LRP2 isoform 1.	0.530
AXIN2	WNT11	ENSPTRP00000016228	ENSPTRP00000007028	AXIN2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.574
AXIN2	WNT5A	ENSPTRP00000016228	ENSPTRP00000086163	AXIN2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.639
BMP4	AXIN2	ENSPTRP00000010780	ENSPTRP00000016228	Bone morphogenetic protein 4.	AXIN2 isoform 1.	0.455
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	FGFR2	ENSPTRP00000010780	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4	ISL1	ENSPTRP00000010780	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4	WNT5A	ENSPTRP00000010780	ENSPTRP00000086163	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.520
BMP4-2	AXIN2	ENSPTRP00000080656	ENSPTRP00000016228	Bone morphogenetic protein 4.	AXIN2 isoform 1.	0.455
BMP4-2	FGF10	ENSPTRP00000080656	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4-2	FGFR2	ENSPTRP00000080656	ENSPTRP00000005308	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.492
BMP4-2	ISL1	ENSPTRP00000080656	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4-2	WNT5A	ENSPTRP00000080656	ENSPTRP00000086163	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.520
FGF10	BMP4	ENSPTRP00000083399	ENSPTRP00000010780	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.696
FGF10	BMP4-2	ENSPTRP00000083399	ENSPTRP00000080656	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.696
FGF10	FGFR2	ENSPTRP00000083399	ENSPTRP00000005308	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.996
FGF10	GLI3	ENSPTRP00000083399	ENSPTRP00000032656	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.511
FGF10	ISL1	ENSPTRP00000083399	ENSPTRP00000028882	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	ISL LIM homeobox 1.	0.402