20 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PINK1	PTEN induced putative kinase 1. (581 aa)
	MMP3	Matrix metallopeptidase 3 (Stromelysin 1, progelatinase). (477 aa)
	DUOXA2	Dual oxidase maturation factor 2. (320 aa)
	DUOXA1	Dual oxidase maturation factor 1. (464 aa)
	ZNF205	Zinc finger protein 205. (554 aa)
	MT3	MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (400 aa)
	PRDX2	PRDX2 isoform 1. (198 aa)
	HDAC6	Histone deacetylase 6. (146 aa)
	CK820_G0040173	HP isoform 11. (376 aa)
	ENSPTRP00000066724	annotation not available (166 aa)
	HP	HP isoform 15. (92 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (207 aa)
	NOXA1	NOXA1 isoform 2. (87 aa)
	ZNF205-2	Zinc finger protein 205. (554 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
	RAC1-2	Rac family small GTPase 1. (212 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUOXA1	DUOXA2	ENSPTRP00000012016	ENSPTRP00000012013	Dual oxidase maturation factor 1.	Dual oxidase maturation factor 2.	0.518
DUOXA1	NOXA1	ENSPTRP00000012016	ENSPTRP00000071309	Dual oxidase maturation factor 1.	NOXA1 isoform 2.	0.575
DUOXA2	DUOXA1	ENSPTRP00000012013	ENSPTRP00000012016	Dual oxidase maturation factor 2.	Dual oxidase maturation factor 1.	0.518
DUOXA2	NOXA1	ENSPTRP00000012013	ENSPTRP00000071309	Dual oxidase maturation factor 2.	NOXA1 isoform 2.	0.465
FYN	RAC2	ENSPTRP00000077482	ENSPTRP00000069135	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	0.498
FYN	SNCA	ENSPTRP00000077482	ENSPTRP00000090843	Tyrosine-protein kinase.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.769
HDAC6	SNCA	ENSPTRP00000037550	ENSPTRP00000090843	Histone deacetylase 6.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.575
NOXA1	DUOXA1	ENSPTRP00000071309	ENSPTRP00000012016	NOXA1 isoform 2.	Dual oxidase maturation factor 1.	0.575
NOXA1	DUOXA2	ENSPTRP00000071309	ENSPTRP00000012013	NOXA1 isoform 2.	Dual oxidase maturation factor 2.	0.465
NOXA1	RAC1	ENSPTRP00000071309	ENSPTRP00000068561	NOXA1 isoform 2.	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.584
NOXA1	RAC1-2	ENSPTRP00000071309	ENSPTRP00000084384	NOXA1 isoform 2.	Rac family small GTPase 1.	0.584
NOXA1	RAC2	ENSPTRP00000071309	ENSPTRP00000069135	NOXA1 isoform 2.	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	0.908
PINK1	SNCA	ENSPTRP00000000500	ENSPTRP00000090843	PTEN induced putative kinase 1.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.874
RAC1	NOXA1	ENSPTRP00000068561	ENSPTRP00000071309	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	NOXA1 isoform 2.	0.584
RAC1-2	NOXA1	ENSPTRP00000084384	ENSPTRP00000071309	Rac family small GTPase 1.	NOXA1 isoform 2.	0.584
RAC2	FYN	ENSPTRP00000069135	ENSPTRP00000077482	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	Tyrosine-protein kinase.	0.498
RAC2	NOXA1	ENSPTRP00000069135	ENSPTRP00000071309	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	NOXA1 isoform 2.	0.908
SNCA	FYN	ENSPTRP00000090843	ENSPTRP00000077482	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	Tyrosine-protein kinase.	0.769
SNCA	HDAC6	ENSPTRP00000090843	ENSPTRP00000037550	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	Histone deacetylase 6.	0.575
SNCA	PINK1	ENSPTRP00000090843	ENSPTRP00000000500	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	PTEN induced putative kinase 1.	0.874