46 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLIS1	GLIS1 isoform 1. (861 aa)
	LMO4	LIM domain only 4. (165 aa)
	GATAD2B	GATAD2B isoform 3. (593 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	NKX6-2	NKX6-2 isoform 1. (276 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	CHD3	Chromodomain helicase DNA binding protein 3. (2058 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	MBD3L1	Methyl-CpG binding domain protein 3 like 1. (194 aa)
	GATAD2A	GATA zinc finger domain containing 2A. (634 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (335 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	MBD3	Methyl-CpG binding domain protein 3. (291 aa)
	IL12RB1	IL12RB1 isoform 1. (662 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	MTA2	Metastasis associated 1 family, member 2. (673 aa)
	LOC748850	HDAC2 isoform 9. (445 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	RBBP4	RB binding protein 4, chromatin remodeling factor. (425 aa)
	IL23R	IL23R isoform 1. (629 aa)
	ENSPTRP00000072489	annotation not available (673 aa)
	LOXL3	Lysyl oxidase-like 3. (753 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	ENSPTRP00000080206	annotation not available (395 aa)
	TNFSF18	Tumor necrosis factor ligand 2A. (199 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	MTA1	Metastasis associated 1. (743 aa)
	ENSPTRP00000082945	annotation not available (603 aa)
	CHD4	Chromodomain helicase DNA binding protein 4. (1912 aa)
	ENSPTRP00000085589	annotation not available (393 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	SOSTDC1-2	Sclerostin domain containing 1. (206 aa)
	ESRP1	Epithelial splicing regulatory protein 1. (681 aa)
	MTA3	Metastasis associated 1 family member 3. (594 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	HDAC1	ENSPTRP00000076864	ENSPTRP00000075891	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.877
AR	HDAC2	ENSPTRP00000076864	ENSPTRP00000049696	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.586
AR	LOC748850	ENSPTRP00000076864	ENSPTRP00000067224	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	HDAC2 isoform 9.	0.877
AR	SPDEF	ENSPTRP00000076864	ENSPTRP00000030856	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	SAM pointed domain containing ETS transcription factor.	0.508
BMP4	BMPR1A	ENSPTRP00000010780	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	DKK1	ENSPTRP00000010780	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4	ENSPTRP00000064416	ENSPTRP00000010780	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4	SOSTDC1-2	ENSPTRP00000010780	ENSPTRP00000089285	Bone morphogenetic protein 4.	Sclerostin domain containing 1.	0.478
BMP4	SOX17	ENSPTRP00000010780	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4	WNT3A	ENSPTRP00000010780	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
BMP4	WNT5A	ENSPTRP00000010780	ENSPTRP00000086163	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.520
BMP4-2	BMPR1A	ENSPTRP00000080656	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.892
BMP4-2	DKK1	ENSPTRP00000080656	ENSPTRP00000004327	Bone morphogenetic protein 4.	Dickkopf-like protein 1.	0.566
BMP4-2	ENSPTRP00000064416	ENSPTRP00000080656	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4-2	SOSTDC1-2	ENSPTRP00000080656	ENSPTRP00000089285	Bone morphogenetic protein 4.	Sclerostin domain containing 1.	0.478
BMP4-2	SOX17	ENSPTRP00000080656	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4-2	WNT3A	ENSPTRP00000080656	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
BMP4-2	WNT5A	ENSPTRP00000080656	ENSPTRP00000086163	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.520
BMPR1A	BMP4	ENSPTRP00000004727	ENSPTRP00000010780	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.988
BMPR1A	BMP4-2	ENSPTRP00000004727	ENSPTRP00000080656	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.892