STRINGSTRING
ENSPTRP00000088702 ENSPTRP00000088702 HDAC7 HDAC7 GPI GPI SASH1 SASH1 PDPK1 PDPK1 FGF18 FGF18 ANGPT1 ANGPT1 VEGFA VEGFA SIRT1-2 SIRT1-2 ADGRA2 ADGRA2 PIK3CD PIK3CD TMSB4X-2 TMSB4X-2 PTGS2 PTGS2 AGT AGT NRP1 NRP1 SIRT1 SIRT1 PIK3C2A PIK3C2A SP1 SP1 ATP5F1B ATP5F1B P2RX4 P2RX4 PRKD1 PRKD1 BMP4 BMP4 HIF1A HIF1A RHOJ RHOJ LGMN LGMN CIB1 CIB1 ALOX12 ALOX12 STAT5A STAT5A GRN GRN MAP3K3 MAP3K3 PRKCA PRKCA CCBE1 CCBE1 BSG BSG CALR CALR TGFB1 TGFB1 PRKD2 PRKD2 RRAS RRAS ZNF580 ZNF580 NRP2 NRP2 AAMP AAMP ANGPT4 ANGPT4 PLCG1 PLCG1 HMOX1 HMOX1 PDGFB PDGFB TDGF1 TDGF1 PIK3CB PIK3CB FGFBP1 FGFBP1 KDR KDR ANXA3 ANXA3 EGF EGF VEGFC VEGFC SEMA5A SEMA5A PLK2 PLK2 FGF1 FGF1 SPARC SPARC EDN1 EDN1 GPLD1 GPLD1 NUS1 NUS1 PLG PLG HDAC9 HDAC9 JCAD JCAD HSPB1 HSPB1 NOS3 NOS3 PTK2B PTK2B TSTA3 TSTA3 AMOT AMOT PIK3CG PIK3CG FGF16 FGF16 FLT4 FLT4 TMSB4X TMSB4X BMPR2 BMPR2 ANXA1 ANXA1 PROX1 PROX1 ADAM17 ADAM17 FOXC2 FOXC2 GATA2 GATA2 LOC741304 LOC741304 ENSPTRP00000061486 ENSPTRP00000061486 CK820_G0012168 CK820_G0012168 ROCK2 ROCK2 NFE2L2 NFE2L2 GATA3 GATA3 ATP5F1A ATP5F1A WNT7A WNT7A FGFR1 FGFR1 RHOB RHOB THBS1 THBS1 ATOH8 ATOH8 FGF2 FGF2 CD40 CD40 ITGB3 ITGB3 RAC1 RAC1 ZC3H12A ZC3H12A ENSPTRP00000069497 ENSPTRP00000069497 TEK TEK BCAS3 BCAS3 RIN2 RIN2 ABL1 ABL1 ENSPTRP00000073361 ENSPTRP00000073361 ENSPTRP00000075003 ENSPTRP00000075003 FOXP1 FOXP1 ENSPTRP00000076371 ENSPTRP00000076371 ENSPTRP00000076822 ENSPTRP00000076822 PLPP3 PLPP3 SCARB1 SCARB1 BCAR1 BCAR1 BMP4-2 BMP4-2 SRPX2 SRPX2 FUT1 FUT1 AKT1 AKT1 ITGB1BP1 ITGB1BP1 MET MET CK820_G0053450-2 CK820_G0053450-2 SMOC2 SMOC2 RAC1-2 RAC1-2 EMC10 EMC10 AKT3 AKT3 WNT5A WNT5A ETS1 ETS1 ENSPTRP00000087640 ENSPTRP00000087640
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000088702annotation not available (170 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (597 aa)
SASH1SAM and SH3 domain containing 1. (1251 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SIRT1-2Sirtuin 1. (751 aa)
ADGRA2G protein-coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TMSB4X-2Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (54 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SIRT1SIRT1 isoform 2. (751 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
SP1Sp1 transcription factor. (786 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
RHOJRas homolog gene family, member J. (214 aa)
LGMNLGMN isoform 1. (433 aa)
CIB1Calcium and integrin binding 1. (231 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
GRNGranulin precursor. (593 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
BSGBSG isoform 8. (383 aa)
CALRCalreticulin. (414 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
RRASRelated RAS viral (R-ras) oncogene homolog. (218 aa)
ZNF580Zinc finger protein 580. (172 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
AAMPAngio associated migratory cell protein. (435 aa)
ANGPT4ANGPT4 isoform 1. (503 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ANXA3Annexin. (323 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
EDN1EDN1 isoform 1. (212 aa)
GPLD1GPLD1 isoform 2. (840 aa)
NUS1Nuclear undecaprenyl pyrophosphate synthase 1 homolog. (293 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
JCADJCAD isoform 2. (1354 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
AMOTAMOT isoform 2. (1094 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
TMSB4XThymosin beta 4 X-linked. (44 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
PROX1Prospero homeobox 1. (737 aa)
ADAM17ADAM17 isoform 3. (999 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
GATA2GATA binding protein 2. (480 aa)
LOC741304Dehydrodolichyl diphosphate synthase complex subunit NUS1. (278 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
GATA3GATA binding protein 3. (444 aa)
ATP5F1AATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (576 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
RHOBRas homolog gene family, member B. (286 aa)
THBS1Thrombospondin 1. (1173 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
CD40CD40 molecule, TNF receptor superfamily member 5. (277 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSPTRP00000069497annotation not available (53 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
RIN2Ras and Rab interactor 2. (944 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSPTRP00000073361annotation not available (388 aa)
ENSPTRP00000075003annotation not available (254 aa)
FOXP1FOXP1 isoform 2. (693 aa)
ENSPTRP00000076371annotation not available (194 aa)
ENSPTRP00000076822annotation not available (142 aa)
PLPP3T0036865 isoform 1. (342 aa)
SCARB1SCARB1 isoform 8; Belongs to the CD36 family. (552 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
SRPX2Sushi-repeat containing protein, X-linked 2. (469 aa)
FUT1Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. Belongs to the glycosyltransferase 11 family. (366 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
CK820_G0053450-2MAP2K3 isoform 2. (298 aa)
SMOC2SPARC related modular calcium binding 2. (398 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
EMC10ER membrane protein complex subunit 10. (371 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ENSPTRP00000087640annotation not available (475 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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