36 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	KIFAP3	Kinesin-associated protein 3. (792 aa)
	BNIP3	BCL2 interacting protein 3. (259 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	LTK	Tyrosine-protein kinase receptor. (864 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	MYOCD	MYOCD isoform 2. (986 aa)
	GATA6	GATA binding protein 6. (594 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	POU4F2	POU domain protein. (406 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	NKX2-5	NKX2-5 isoform 1. (325 aa)
	PPP1R10	Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (940 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator-like 2. (777 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
	FNDC1	FNDC1 isoform 1. (1888 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	NFE2L2	Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
	NOL3	Nucleolar protein 3. (219 aa)
	GATA4	GATA binding protein 4. (443 aa)
	CK820_G0040447	CAPN2 isoform 2; Belongs to the peptidase C2 family. (708 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	JAK2	Tyrosine-protein kinase. (1143 aa)
	MDK	Midkine (Neurite growth-promoting factor 2). (143 aa)
	PAX8	PAX8 isoform 1. (456 aa)
	AMBRA1	AMBRA1 isoform 6. (1298 aa)
	HSF1	Heat shock transcription factor 1. (529 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (446 aa)
	PDPK1	3-phosphoinositide dependent protein kinase-1. (542 aa)
	CAPN2	Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (703 aa)
	NRG1	NRG1 isoform 3. (713 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG5	ENSPTRP00000086409	ENSPTRP00000031526	AMBRA1 isoform 6.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.601
AMBRA1	BNIP3	ENSPTRP00000086409	ENSPTRP00000005394	AMBRA1 isoform 6.	BCL2 interacting protein 3.	0.497
ATG5	AMBRA1	ENSPTRP00000031526	ENSPTRP00000086409	Autophagy protein 5; Involved in autophagic vesicle formation.	AMBRA1 isoform 6.	0.601
ATG5	BNIP3	ENSPTRP00000031526	ENSPTRP00000005394	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 interacting protein 3.	0.545
ATG5	CFLAR	ENSPTRP00000031526	ENSPTRP00000078536	Autophagy protein 5; Involved in autophagic vesicle formation.	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.	0.509
ATG5	TP53	ENSPTRP00000031526	ENSPTRP00000014836	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.575
BNIP3	AMBRA1	ENSPTRP00000005394	ENSPTRP00000086409	BCL2 interacting protein 3.	AMBRA1 isoform 6.	0.497
BNIP3	ATG5	ENSPTRP00000005394	ENSPTRP00000031526	BCL2 interacting protein 3.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.545
BNIP3	TP53	ENSPTRP00000005394	ENSPTRP00000014836	BCL2 interacting protein 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.617
CAMK2A	CAMK2D	ENSPTRP00000080192	ENSPTRP00000088560	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	Calcium/calmodulin dependent protein kinase II delta.	0.971
CAMK2D	CAMK2A	ENSPTRP00000088560	ENSPTRP00000080192	Calcium/calmodulin dependent protein kinase II delta.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.971
CFLAR	ATG5	ENSPTRP00000078536	ENSPTRP00000031526	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.509
CFLAR	TP53	ENSPTRP00000078536	ENSPTRP00000014836	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.612
GATA4	GATA6	ENSPTRP00000075865	ENSPTRP00000016858	GATA binding protein 4.	GATA binding protein 6.	0.493
GATA4	HAND2	ENSPTRP00000075865	ENSPTRP00000050916	GATA binding protein 4.	Heart and neural crest derivatives expressed 2.	0.905
GATA4	HEY2	ENSPTRP00000075865	ENSPTRP00000031710	GATA binding protein 4.	Hairy/enhancer-of-split related with YRPW motif 2.	0.599
GATA4	MYOCD	ENSPTRP00000075865	ENSPTRP00000014974	GATA binding protein 4.	MYOCD isoform 2.	0.696
GATA4	NKX2-5	ENSPTRP00000075865	ENSPTRP00000029961	GATA binding protein 4.	NKX2-5 isoform 1.	0.998
GATA6	GATA4	ENSPTRP00000016858	ENSPTRP00000075865	GATA binding protein 6.	GATA binding protein 4.	0.493
GATA6	HAND2	ENSPTRP00000016858	ENSPTRP00000050916	GATA binding protein 6.	Heart and neural crest derivatives expressed 2.	0.710