STRINGSTRING
SPRED3 SPRED3 ACVR1 ACVR1 TGFBR2 TGFBR2 TGFBR1 TGFBR1 NKX2-1 NKX2-1 LOC739666 LOC739666 DAB2 DAB2 CLASP1 CLASP1 TBX5 TBX5 IL6 IL6 MCRIP1 MCRIP1 SNAI1 SNAI1 LOXL2 LOXL2 SPRED2 SPRED2 FOXC1 FOXC1 MARK1 MARK1 CLASP2 CLASP2 GATA3 GATA3 SDCBP SDCBP PPP2CA PPP2CA FOXA1 FOXA1 SMAD2 SMAD2 DAB2IP DAB2IP TRIM62 TRIM62 PHLDB2 PHLDB2 VASN VASN SFRP1 SFRP1 USF3 USF3 HDAC2 HDAC2 DACT3 DACT3 TWIST1 TWIST1 WWTR1 WWTR1 CTNNB1 CTNNB1 PHLDB1 PHLDB1 OLFM1 OLFM1 CRB2 CRB2 NOTCH1 NOTCH1 ENG ENG ZNF703 ZNF703 TBX20 TBX20 BMP5 BMP5 ENSPTRP00000029492 ENSPTRP00000029492 ISL1 ISL1 SFRP2 SFRP2 EPHA3 EPHA3 IL17RD IL17RD DAG1 DAG1 POFUT2 POFUT2 TIAM1 TIAM1 BMP7 BMP7 JAG1 JAG1 BMP2 BMP2 IL1B IL1B FUZ FUZ TGFB1 TGFB1 SPRED3-2 SPRED3-2 HPN HPN LRG1 LRG1 SMAD4 SMAD4 SMAD7 SMAD7 ZNF750 ZNF750 AXIN2 AXIN2 NOG NOG COL1A1 COL1A1 ELL3 ELL3 SPRED1 SPRED1 TGFB3 TGFB3 BMP4 BMP4 SPRY2 SPRY2 RGCC RGCC ALX1 ALX1 PAWR PAWR BCL9L BCL9L BAMBI BAMBI TGFB2 TGFB2 ADIPOR1 ADIPOR1 EFNA1 EFNA1 PDPN PDPN MAD2L2 MAD2L2 MTOR MTOR IL6-2 IL6-2 LEF1 LEF1 TGFB1I1 TGFB1I1 EZH2 EZH2 BMP4-2 BMP4-2 FERMT2 FERMT2 TCF7L2 TCF7L2 LDLRAD4 LDLRAD4 SPRY1 SPRY1 GCNT2 GCNT2 MDK MDK EPHA4 EPHA4 ENSPTRP00000086563 ENSPTRP00000086563 SERPINB3 SERPINB3 ENSPTRP00000089475 ENSPTRP00000089475 FOXA2 FOXA2 EZH2-2 EZH2-2 EMP2 EMP2 SMAD3 SMAD3 PTEN PTEN OVOL2 OVOL2 GLIPR2 GLIPR2 ENSPTRP00000093022 ENSPTRP00000093022
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRED3Sprouty related EVH1 domain containing 3. (410 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
LOC739666Syntenin-1-like. (289 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
CLASP1Cytoplasmic linker associated protein 1. (1549 aa)
TBX5T-box transcription factor 5. (518 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
MCRIP1MCRIP1 isoform 6. (119 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LOXL2LOXL2 isoform 4. (744 aa)
SPRED2SPRED2 isoform 3. (432 aa)
FOXC1FOXC1 isoform 1. (550 aa)
MARK1Non-specific serine/threonine protein kinase. (796 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
GATA3GATA binding protein 3. (444 aa)
SDCBPSyndecan binding protein. (324 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
FOXA1FOXA1 isoform 1. (471 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
TRIM62Tripartite motif containing 62. (475 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
VASNVASN isoform 1. (673 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
USF3USF3 isoform 1. (2240 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (181 aa)
TWIST1TWIST1 isoform 2. (163 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1377 aa)
OLFM1OLFM1 isoform 3. (485 aa)
CRB2CRB2 isoform 1. (1285 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
ZNF703Zinc finger protein 703. (590 aa)
TBX20T-box transcription factor 20. (447 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
ENSPTRP00000029492annotation not available (223 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
EPHA3EPH receptor A3. (983 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. O-fucosylation of TSRs is also requir [...] (413 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SPRED3-2Sprouty related EVH1 domain containing 3. (454 aa)
HPNHPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (347 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
ZNF750Zinc finger protein 750. (723 aa)
AXIN2AXIN2 isoform 1. (843 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SPRY2Sprouty homolog 2. (338 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
ALX1ALX homeobox 1. (326 aa)
PAWRPRKC, apoptosis, WT1, regulator. (340 aa)
BCL9LB-cell CLL/lymphoma 9-like. (1499 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
PDPNPDPN isoform 3. (238 aa)
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IL6-2Interleukin 6. (234 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FERMT2Fermitin family member 2. (706 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group). (402 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
EPHA4EPH receptor A4. (986 aa)
ENSPTRP00000086563annotation not available (245 aa)
SERPINB3SERPINB3 isoform 1; Belongs to the serpin family. (390 aa)
ENSPTRP00000089475annotation not available (268 aa)
FOXA2FOXA2 isoform 1. (464 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] (167 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
GLIPR2GLIPR2 isoform 2; Belongs to the CRISP family. (165 aa)
ENSPTRP00000093022annotation not available (563 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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