(26 nodes) Protein kinase A signaling network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPTRP00000086247	annotation not available (513 aa)
	EZR	EZR isoform 1. (671 aa)
	MROH7	Maestro heat-like repeat-containing protein family member 7 isoform X1. (1323 aa)
	RAB13	RAB13, member RAS oncogene family. (203 aa)
	GAL	Galanin and GMAP prepropeptide. (123 aa)
	LCP1	Lymphocyte cytosolic protein 1. (627 aa)
	MRO	MRO isoform 1. (248 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	TTN	TTN isoform 3. (32000 aa)
	MROH8	MROH8 isoform 1. (926 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	MROH2B	Maestro heat like repeat family member 2B. (1585 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	ENSPTRP00000038048	T-complex 11 family, X-linked 2. (350 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	GCG	GCG isoform 1. (180 aa)
	MYOM1	MYOM1 isoform 1. (1647 aa)
	TCP11X2	TCP11X2 isoform 1. (407 aa)
	MROH5	MROH5 isoform 2. (1283 aa)
	FBN1	FBN1 isoform 1. (2871 aa)
	TCP11	TCP11 isoform 10. (441 aa)
	RDX	RDX isoform 3. (609 aa)
	TCP11X2-2	TCP11X2 isoform 2. (384 aa)
	MROH2A	MROH2A isoform 2. (1290 aa)
	MROH1	HEAT repeat containing 7A. (1641 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSPTRP00000030273	ENSPTRP00000028311	EDN1 isoform 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	GCG	ENSPTRP00000030273	ENSPTRP00000049083	EDN1 isoform 1.	GCG isoform 1.	0.406
EDNRA	EDN1	ENSPTRP00000028311	ENSPTRP00000030273	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	EDN1 isoform 1.	0.999
ENSPTRP00000086247	EZR	ENSPTRP00000086247	ENSPTRP00000093858	annotation not available	EZR isoform 1.	0.961
EZR	ENSPTRP00000086247	ENSPTRP00000093858	ENSPTRP00000086247	EZR isoform 1.	annotation not available	0.961
EZR	PRKACA	ENSPTRP00000093858	ENSPTRP00000018062	EZR isoform 1.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.978
EZR	PRKACB	ENSPTRP00000093858	ENSPTRP00000042330	EZR isoform 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.978
EZR	PRKACG	ENSPTRP00000093858	ENSPTRP00000035898	EZR isoform 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.978
EZR	RDX	ENSPTRP00000093858	ENSPTRP00000073243	EZR isoform 1.	RDX isoform 3.	0.999
GAL	GCG	ENSPTRP00000006860	ENSPTRP00000049083	Galanin and GMAP prepropeptide.	GCG isoform 1.	0.408
GCG	EDN1	ENSPTRP00000049083	ENSPTRP00000030273	GCG isoform 1.	EDN1 isoform 1.	0.406
GCG	GAL	ENSPTRP00000049083	ENSPTRP00000006860	GCG isoform 1.	Galanin and GMAP prepropeptide.	0.408
GCG	PRKACA	ENSPTRP00000049083	ENSPTRP00000018062	GCG isoform 1.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.545
GCG	PRKACB	ENSPTRP00000049083	ENSPTRP00000042330	GCG isoform 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.545
GCG	PRKACG	ENSPTRP00000049083	ENSPTRP00000035898	GCG isoform 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.545
MROH2A	MROH2B	ENSPTRP00000074233	ENSPTRP00000028842	MROH2A isoform 2.	Maestro heat like repeat family member 2B.	0.462
MROH2B	MROH2A	ENSPTRP00000028842	ENSPTRP00000074233	Maestro heat like repeat family member 2B.	MROH2A isoform 2.	0.462
MROH2B	MROH7	ENSPTRP00000028842	ENSPTRP00000001342	Maestro heat like repeat family member 2B.	Maestro heat-like repeat-containing protein family member 7 isoform X1.	0.403
MROH7	MROH2B	ENSPTRP00000001342	ENSPTRP00000028842	Maestro heat-like repeat-containing protein family member 7 isoform X1.	Maestro heat like repeat family member 2B.	0.403
PRKACA	EZR	ENSPTRP00000018062	ENSPTRP00000093858	PRKACA isoform 7; Belongs to the protein kinase superfamily.	EZR isoform 1.	0.978