STRINGSTRING
NEDD4L NEDD4L PCSK9 PCSK9 WNK4 WNK4 SLC9A3R1 SLC9A3R1 GRP GRP OSR1 OSR1 PRKCE PRKCE COMMD1 COMMD1 STK39 STK39 HECW2 HECW2 SERPINE2 SERPINE2 WNK3 WNK3 WNK2 WNK2 WNK1 WNK1 ATP1A2 ATP1A2 NEDD4 NEDD4 CAMK2D CAMK2D HECW1 HECW1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEDD4LNEDD4L isoform 6. (1254 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa)
WNK4WNK lysine deficient protein kinase 4. (1282 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
GRPGastrin releasing peptide. (138 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
COMMD1Copper metabolism (Murr1) domain containing 1. (190 aa)
STK39Serine threonine kinase 39. (545 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
WNK3WNK3 isoform 5. (1797 aa)
WNK2WNK2 isoform 4. (2235 aa)
WNK1WNK1 isoform 4. (2833 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1608 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.