STRINGSTRING
AP1AR AP1AR MYOC MYOC MEN1 MEN1 FZD4 FZD4 PLET1 PLET1 WNT1 WNT1 ACVRL1 ACVRL1 CORO1C CORO1C MMP14 MMP14 CORO2B CORO2B CX3CL1 CX3CL1 NF1 NF1 COL1A1 COL1A1 JAG1 JAG1 RHOA RHOA MELTF MELTF RASA1 RASA1 EFNA5 EFNA5 SPOCK1 SPOCK1 SPRY4 SPRY4 PLG PLG SERPINE1 SERPINE1 ANGPT2 ANGPT2 DLC1 DLC1 ACER2 ACER2 NOTCH1 NOTCH1 ARHGAP6 ARHGAP6 DMTN DMTN ADAM15 ADAM15 KANK1 KANK1 CASK CASK RCC2 RCC2 PHLDB2 PHLDB2 FBLN1 FBLN1 CLASP2 CLASP2 SEMA3E SEMA3E THBS1 THBS1 ENSPTRP00000067778 ENSPTRP00000067778 ENSPTRP00000067847 ENSPTRP00000067847 BCL6 BCL6 DUSP22 DUSP22 BCAS3 BCAS3 NF2 NF2 FAM107A FAM107A SRC SRC CDKN2A CDKN2A PIK3R1 PIK3R1 PTPRO PTPRO MAP4K4 MAP4K4 ACTN4 ACTN4 APOD APOD AJAP1 AJAP1 ITGB1BP1 ITGB1BP1 GBP1 GBP1 GCNT2 GCNT2 TBCD TBCD FZD7 FZD7 NEXMIF NEXMIF PTEN PTEN MMP12 MMP12 ENSPTRP00000093022 ENSPTRP00000093022 TACSTD2 TACSTD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AP1ARAdaptor-related protein complex 1-associated regulatory protein. (302 aa)
MYOCMYOC isoform 1. (504 aa)
MEN1MEN1 isoform 14. (615 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
PLET1Placenta expressed transcript 1. (207 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
NF1Neurofibromin 1. (2839 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RHOARas homolog family member A. (193 aa)
MELTFMELTF isoform 2; Belongs to the transferrin family. (739 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
SPOCK1Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (439 aa)
SPRY4SPRY4 isoform 1. (322 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ARHGAP6Rho GTPase activating protein 6. (974 aa)
DMTNDematin actin binding protein. (405 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
KANK1KANK1 isoform 8. (1345 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (921 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSPTRP00000067778annotation not available (85 aa)
ENSPTRP00000067847annotation not available (809 aa)
BCL6BCL6 transcription repressor. (706 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
FAM107AActin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
SRCTyrosine-protein kinase. (542 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
MAP4K4MAP4K4 isoform 6. (1347 aa)
ACTN4Actinin, alpha 4. (931 aa)
APODApolipoprotein D. (215 aa)
AJAP1Adherens junctions associated protein 1. (411 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
GBP1Guanylate binding protein 1. (594 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group). (402 aa)
TBCDTBCD isoform 2. (1224 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MMP12MMP12 isoform 1. (470 aa)
ENSPTRP00000093022annotation not available (563 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.