STRINGSTRING
SPRY4 SPRY4 SPOCK1 SPOCK1 EFNA5 EFNA5 RASA1 RASA1 MELTF MELTF RHOA RHOA JAG1 JAG1 COL1A1 COL1A1 NF1 NF1 CX3CL1 CX3CL1 CORO2B CORO2B MMP14 MMP14 CORO1C CORO1C ACVRL1 ACVRL1 WNT1 WNT1 PLET1 PLET1 FZD4 FZD4 MEN1 MEN1 MYOC MYOC TACSTD2 TACSTD2 ENSPTRP00000093022 ENSPTRP00000093022 AP1AR AP1AR MMP12 MMP12 PTEN PTEN NEXMIF NEXMIF FZD7 FZD7 TBCD TBCD GCNT2 GCNT2 GBP1 GBP1 ITGB1BP1 ITGB1BP1 AJAP1 AJAP1 APOD APOD ACTN4 ACTN4 MAP4K4 MAP4K4 PTPRO PTPRO PIK3R1 PIK3R1 CDKN2A CDKN2A SRC SRC FAM107A FAM107A NF2 NF2 BCAS3 BCAS3 DUSP22 DUSP22 BCL6 BCL6 ENSPTRP00000067847 ENSPTRP00000067847 ENSPTRP00000067778 ENSPTRP00000067778 THBS1 THBS1 SEMA3E SEMA3E CLASP2 CLASP2 FBLN1 FBLN1 PHLDB2 PHLDB2 RCC2 RCC2 CASK CASK KANK1 KANK1 ADAM15 ADAM15 DMTN DMTN ARHGAP6 ARHGAP6 NOTCH1 NOTCH1 ACER2 ACER2 DLC1 DLC1 ANGPT2 ANGPT2 SERPINE1 SERPINE1 PLG PLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRY4SPRY4 isoform 1. (322 aa)
SPOCK1Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (439 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
MELTFMELTF isoform 2; Belongs to the transferrin family. (739 aa)
RHOARas homolog family member A. (193 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
NF1Neurofibromin 1. (2839 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PLET1Placenta expressed transcript 1. (207 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
MEN1MEN1 isoform 14. (615 aa)
MYOCMYOC isoform 1. (504 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
ENSPTRP00000093022annotation not available (563 aa)
AP1ARAdaptor-related protein complex 1-associated regulatory protein. (302 aa)
MMP12MMP12 isoform 1. (470 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
TBCDTBCD isoform 2. (1224 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group). (402 aa)
GBP1Guanylate binding protein 1. (594 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
AJAP1Adherens junctions associated protein 1. (411 aa)
APODApolipoprotein D. (215 aa)
ACTN4Actinin, alpha 4. (931 aa)
MAP4K4MAP4K4 isoform 6. (1347 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SRCTyrosine-protein kinase. (542 aa)
FAM107AActin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSPTRP00000067847annotation not available (809 aa)
ENSPTRP00000067778annotation not available (85 aa)
THBS1Thrombospondin 1. (1173 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (921 aa)
KANK1KANK1 isoform 8. (1345 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
DMTNDematin actin binding protein. (405 aa)
ARHGAP6Rho GTPase activating protein 6. (974 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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