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TGFB3 TGFB3 GDF11 GDF11 INHBC INHBC INHBE INHBE INHBA INHBA INHBB INHBB ENSPTRP00000089475 ENSPTRP00000089475 ENSPTRP00000086563 ENSPTRP00000086563 GDF9-2 GDF9-2 BMP4-2 BMP4-2 LEFTY1 LEFTY1 HFE HFE BMP10 BMP10 PPARG PPARG GDF6 GDF6 ACVR1 ACVR1 TGFBR2 TGFBR2 TGFBR1 TGFBR1 LOC739666 LOC739666 DAB2 DAB2 GDF2 GDF2 ENSPTRP00000064416 ENSPTRP00000064416 SDCBP SDCBP BMPR2 BMPR2 GDF10 GDF10 BMP15 BMP15 ENG ENG RBPMS RBPMS TTK TTK BMP5 BMP5 BMP6 BMP6 GDF9 GDF9 BMP3 BMP3 BMP7 BMP7 GDF5 GDF5 BMP2 BMP2 INHA INHA MSTN MSTN ACVR2A ACVR2A GDF7 GDF7 TGFB1 TGFB1 GDF15 GDF15 SMAD4 SMAD4 TWSG1 TWSG1 ACVRL1 ACVRL1 BMP4 BMP4 ENSPTRP00000000998 ENSPTRP00000000998 BMP8B BMP8B TGFB2 TGFB2 LEFTY2 LEFTY2 NODAL NODAL BMPR1A BMPR1A GDF3 GDF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF11GDF11 isoform 1. (407 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (350 aa)
INHBAInhibin subunit beta A. (426 aa)
INHBBInhibin subunit beta B. (407 aa)
ENSPTRP00000089475annotation not available (268 aa)
ENSPTRP00000086563annotation not available (245 aa)
GDF9-2Growth differentiation factor 9. (455 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LEFTY1Left-right determination factor. (366 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
GDF6Growth differentiation factor 6. (455 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
LOC739666Syntenin-1-like. (289 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
GDF2GDF2 isoform 1. (429 aa)
ENSPTRP00000064416annotation not available (502 aa)
SDCBPSyndecan binding protein. (324 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
BMP15BMP15 isoform 1. (369 aa)
ENGENG isoform 1. (658 aa)
RBPMSRNA binding protein, mRNA processing factor. (219 aa)
TTKTTK protein kinase. (856 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
GDF9Growth differentiation factor 9. (455 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF7Growth differentiation factor 7. (447 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF15Growth differentiation factor 15. (308 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000000998annotation not available (224 aa)
BMP8BBMP8B isoform 1. (402 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LEFTY2Left-right determination factor. (366 aa)
NODALNODAL isoform 2. (347 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF3Growth differentiation factor 3. (364 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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